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Aliness Homocysteine regulator is a dietary supplement that helps to maintain optimal levels of homocysteine and promotes the proper course of methylation processes. It contains B vitamins (B2, B6, B9, B12), trimethylglycine, cholinę, and N-acetyl-L-cysteine (NAC). The preparation is suitable for people on a plant-based diet.
The preparation supports the methylation process, which is one of the key and most complex processes in the body. Its proper course determines, among others, the formation and repair of damaged DNA strands, detoxification of the body, the formation of immune cells and neurotransmitters, as well as energy generation.
The preparation helps to maintain the proper level of homocysteine. It is a by-product of the methylation process, and, since its excess may pose a health hazard, it must be properly removed from the body. Its increased level is a risk factor for cardiovascular diseases. It has been proven that homocysteine promotes the degradation of collagen, elastin, and proteoglycans, whereas in high concentrations undergoes autoxidation and reacts with reactive oxygen species. Thus, it causes irreversible changes in the structure of blood vessels, increases the risk of atherosclerotic plaque build-up and the formation of blood clots.
The preparation is a source of vitamins B2, B6, B9, B12. Their proper supply is one of the factors that determine the proper course of methylation processes and the efficient utilization of homocysteine. Importantly, all vitamins included in the preparation are available in biologically active and perfectly digestible forms (including folic acid in the patented, highly effective form of Quatrefolic® 5-methyltetrahydrofolate). This is especially important for people with the MTHFR gene mutation, in whom the process of converting folic acid to its active form is disturbed, and supplementation with synthetic vitamin B9 causes more harm than good.
The preparation has been enriched with choline, TMG, and NAC. They are excellent complementation to the treatment with the above-mentioned vitamins. They help to maintain normal homocysteine levels, however, using different pathways and mechanisms (the so-called "the shortcut route").
To sum up, Aliness Homocysteine Regulator is a formula that comprehensively helps to maintain the proper level of homocysteine, and thus is powerful support for the cardiovascular system.
The preparation is dedicated mainly to people with increased levels of homocysteine. It should also be of interest to people with the MTHFR gene mutation and people struggling with problems that may suggest disturbances in the methylation process (chronic fatigue, depressed mood, problems with fertility).
During supplementation, you should not reach for other supplements containing B vitamins. If vitamins C or D are taken in parallel, take them a few hours before or after taking the presented supplement.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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|per 1 portion (1 capsule)||amount||%DV|
|Vitamin B2 (as riboflavin 5’-phosphate)||20 mg||1785,5%|
|Vitamin B6 (as pyridoxal 5’-phosphate)||9 mg||643%|
|Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt)||30 mcg||150%|
|Vitamin B12 including:||50 mcg||2000%|
|- methylcobalamin||25 mcg||-|
|- adenosylcobalamin||25 mcg||-|
|Trimethylglycine (TMG)||400 mg||-|
|Choline (as choline bitartrate VitaCholine™)||125 mg||-|
|N-acetyl-L-cysteine (NAC)||100 mg||-|
Capsule shell: hydroxypropyl methylcellulose (binder).
Vitamin B2 (riboflavin) is soluble in liquids, is involved in the metabolism of proteins, fats and carbohydrates. Required for growth of the organism. Takes part in the production of erythrocytes (red blood cells). It is located in natural foods, such as yeast, meat (especially liver, kidney, heart), milk, fish and green leafy vegetables.
A deficiency of vitamin B2 inhibits the growth, diseases of the mouth, loss and greasy hair, seborrhea and stratification of nails. Increases skin roughness and susceptibility to acne and oily skin.
Dosage: 1-2 mg per day.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Vitamin B12 (cobalamin, cyanocobalamin) is a vitamin soluble in liquids. Participates in the production of red blood cells and is essential in the absorption of iron by the body. It calming effect, a positive effect on concentration and memory. Intensifies its action in cooperation with folic acid (vitamin M). Usually occurs in animal products, fish and dairy products. It contains trace elements.
Vitamin B12 deficiency can lead to pernicious anaemia, general and immunity weakness, inhibiting of growth and damage to the myelin sheath of nerves.
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
Choline belongs to the soluble in liquids group of B vitamins. It is an organic nitrogen base containing lecithin, and acetylcholine. Together with inositol is involved in the metabolism of fats and cholesterol metabolism, preventing its accumulation on the walls of arteries and deposits in the gallbladder. With the penetration of the brain, contained lecithin improves its action and improves memory. Used in the treatment of age-related diseases (Alzheimer's). It occurs in plant foods: yeast, wheat germ, lecithin, green leafy vegetables and egg yolks.
Choline bitartrate a combination of one molecule of tartaric acid and choline, and in this embodiment is a precursor of acetylcholine (neurotransmitter). The human body is able to intracellular synthesis of choline, using the amino acid and vitamin B12. Because of the possibility of shortages of the above mentioned substances, it is necessary to supplement them with supplementation. Choline is a component of lecithin, which is the building substance of cells conditioning the proper functioning of the nervous system, and sphingomyelin, acting as an insulator of nerve tissue. Bitartrate affects the course of fat metabolism. In the sports supplementation of choline, bitartrate is used in the stimulating supplements,, affecting concentration and programs of weight control (fat reduction).
Dosage: 1-3 grams per day.
N-acetyl-L-cysteine (NAC), acetylated form of cysteine, one of the 22 amino acids building proteins, of wide use in medicine and sports supplements. Neutralizes the effects of paracetamol overdose, it is protecting on the liver, influences on the synthesis of glutathione, and the nervous system (effect on NMDA receptors). It increases the body's immunity to inflammation (especially of the upper respiratory tract). Available in the form of medicines and dietary supplements in sports pharmacies and www.muscle-zone.pl
Dosage: the lack of standards unit consumption. Doses as customarily used in supplementation.
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