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Douglas Homocystrol + TMG is a high-quality dietary supplement which contains B vitamin complex, betaine, choline and magnesium. Ingredients and their forms were selected to support actively cardiovascular function, mainly by providing methyl groups required for reducing levels of atherogenic homocysteine. It shows also far-reaching effects on other structures – the liver, the central nervous system and motor system.
The formulation provides highly bioactive forms of B vitamins – methylcobalamin, pyridoxal-5-phosphate (P5P), L-methylfolate and riboflavin-5-phosphate. These are active forms which does not have to be converted and can be used readily by the body.
The product contains:
Riboflavin (riboflavin-5-phosphate) – otherwise known as vitamin B2. Its presence is necessary for processes of aerobic respiration and production of energy required for cell function. It is also a cofactor of the enzyme MTHFR which is involved in the conversion of folic acid, required for reducing homocysteine levels.
Vitamin B6 (pyridoxal-5-phosphate) and vitamin B12 (methylcobalamin) – supports enzymes which convert homocysteine into cysteine (vitamin B6) or methionine (vitamin B12) to help complete the metabolic cycle.
L-Methylfolate (Metafolin®) – the most effective, active form of folic acid which is formed in the body by the enzyme MTHFR and may be a direct donor of methyl groups for reducing homocysteine levels, along with choline and its oxidised form trimethylglycine (betaine). L-Methylfolate is the only form of folate capable of crossing the blood-brain barrier. What is more, it does not mask vitamin B12 deficiencies and contribute to the accumulation of unmodified folic acid in the body.
Magnesium – as the most bioavailable chelate form, it is a key microelement for the functioning of muscle tissue – it prevents excessive muscle cramps. Since the heart is the most important muscle of the body, it regulates its function and is thus an essential preventive measure against arrhythmia.
Helpful in maintaining healthy homocysteine metabolism
Cardiovascular diseases are nowadays the most frequent diseases in the population. Their causes are different and often hard to eliminate. However, we can have a real impact on some of them. A healthy diet, which provides proper macro- and microelements, may delay its progression.
One of the compounds with toxic effects on the cardiovascular and nervous system is homocysteine. It is an intermediate in the metabolic cycle which facilitates the formation of two amino acids – cysteine and methionine. It is not possible without proper enzymes which need cofactors – vitamin B2 (involved in folic acid metabolism), vitamin B6 and vitamin B12 (which regulate the conversion of homocysteine into cysteine or methionine), and donors of methyl groups for regenerating methionine – betaine, choline and L-methylfolate.
A deficiency of these biomolecules may be caused by an unhealthy diet, but it is also observed in smokers, the elderly, excessive alcohol consumers or individuals on contraceptives. It is recommended to monitor homocysteine levels and protect effectively against hyperhomocysteinemia, which may be a risk factor for atherosclerosis that has dangerous consequences.
Other effects of ingredient complex
Along with hyperhomocysteinemia, abnormal carbohydrate and fat metabolism is a frequent cause of cardiovascular diseases, such as atherosclerosis and its complications. Betaine and choline have been shown to protect in multiple ways against excessive homocysteine levels.
These compounds increase primarily insulin sensitivity of liver cells which may store excessive glucose, and thus ensures its proper distribution throughout the body On the other hand, they inhibit the activity of enzymes responsible for lipogenesis, thereby decreasing the accumulation of stored fat, especially as visceral fat, and thus impair significantly the function of the cardiovascular system.
Support for the nervous and motor system
Involuntary muscle contractions are a feeling that is familiar to every human, regardless of age or physical activity. The main cause which comes to mind is magnesium deficiency. In this case, it is recommended to supplement with well-absorbed forms, including magnesium chelate. Its action at the molecular level is to inhibit the influx of calcium ions which initiate a contraction by promoting the secretion of neurotransmitters in the neuromuscular junction and cause tetany seizures in excessive amounts.
Another molecule which supports the functioning of muscle tissue is riboflavin. Its main task is to participate in the processes of metabolic energy production in muscle cells. As a result, fibres provided with an adequate amount of energy may function as effectively as possible.
To sum up, Douglas Homocystrol + TMG is a product designed for everyone who is at risk of a deficiency of biomolecules which leads to an increase in homocysteine levels.
It is intended mainly for individuals who want to improve cardiovascular function to protect against the development of diseases. It may be a good idea to add S-adenosyl methionine to your supplementation regimen which will decrease homocysteine production in a slightly different way.
Individuals at risk of vitamin B12 or folic acid deficiency, i.e. vegans, patients after a gastrectomy and persons who consume too much alcohol (with folic acid deficiency), should test their blood homocysteine levels.
However, we should remember that lifestyle is the main factor which contributes significantly to cardiovascular health and the supplement only corrects dietary deficiencies of microelements.
Douglas Labs is a company set up in 1955 by Sam Lioon, who wanted to help Americans change their lifestyles by means of diet and supplementation and his motto “raise standards” is especially visible today, when the brand produces high-quality supplements on a broad scale.
In the scope of the company’s activities there are also scientific studies, the sale of supplements is based on and also events, where their achievements and the most current knowledge on supplementation are presented. One of the most pioneering products by Douglas Labs are the preparation supporting hormonal balance, bone turnover and many other with multi-system effect.
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|per portion (3 capsules)||amount||%DV|
|Riboflavin (as Riboflavin-5-Phosphate)||50 mg||**|
|Vitamin B6 (as Pyridoxal-5-Phosphate)||50 mg||**|
|Folate (as L-methylfolate, Metafolin®)||800 mcg||**|
|Vitamin B12 (Methylcobalamin)||1000 mcg||**|
|Magnesium (as Magnesium Chelate)||50 mg||**|
|Trimethylglycine (Betaine)||1000 mg||**|
|Choline (as Choline Bitartrate)||150 mg||**|
Hydroxypropyl methylcellulose (capsule), cellulose, vegetable stearate, and silica.
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