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Seeking Health Active B12 5000 is a dietary supplement containing vitamin B12 in the form of the two most bioavailable forms – 80% methylcobalamin, 20% adenosylcobalamin. High assimilability of the preparation’s ingredients makes the product an effective complementation of cobalamin deficiency and protects from the disorders of the circulatory system and nervous system.
Vitamin B12 is a compound, in the composition of which there is corrin system, containing four reduced pyrrole rings and cobalt atom located in the center. It is the only vitamin, the production of which in the organism is possible only in bacterial cells, however, in humans, the main source of this vitamin is food. Cobalamin is a key substance for the proper functioning of the organism, it counteracts pernicious anemia and protects the nervous system.
The main sources of vitamin B12 are primarily all products of animal origin: meat of ruminants, fish, shellfish, poultry, cheese, eggs. This vitamin is also found in large amounts in some algae and vegetables susceptible to the process of fermentation, e.g. miso.
Discovery of vitamin B12
The history of the discovery of vitamin B12 goes back to the year 1835, when the disorder of red cell synthesis was discovered – pernicious anemia. In 1920 it was observed that applying livers to animals which lost a lot of blood helped them to recover faster. In 1948 Rickers and his coworkers isolated the substance which helped to treat anemia – initially it was called vitamin B12 and then cobalamin.
Causes, symptoms and consequences of cobalamin deficiency
Insufficient level of cobalamin in the organism contributes to the increased level of homocysteine, by which it may constitute an increased risk factor of the diseases of the cardiovascular system (increases blood coagulation, disturbs the function of endothelium, intensifies oxidative stress). Moreover, vitamin B12 deficiency also negatively influences the work of the nervous system and increases the susceptibility of DNA to damages.
Among the main symptoms of vitamin B12 deficiency are primarily disorders in blood-forming processes, which consequently may lead to developing pernicious anemia, also called megaloblastic anemia or Addison–Biermer anemia.
Insufficient level of cobalamin in the organism contributes among others to the growth of susceptibility to infections, menstruation disorders, limb numbness, loss of appetite and irritation. Vitamin B12 manifests itself also in the form of neurological disorders: dementia, brain atrophy, ataxia, neuropathy.
The causes of vitamin B12 deficiency are mainly: improper absorption of cobalamin, excessive growth of intestinal flora which uses up this vitamin, diseases of the intestines (Whipple’s disease, Zollinger–Ellison syndrome), states after bowel resection. Increased need for cobalamin is also observed in case of the presence of parasites, overproduction of hydrochloric acid, taking certain drugs, atrophic gastritis and consequently – Castle factor deficiency.
Participation of vitamin B12 in the blood-forming process
Cobalamin is a key element in the process of red cell synthesis. This vitamin by binding with glycoprotein – an internal factor (also called Castle factor) secreted by parietal cells of the stomach constitutes an element of erythropoiesis and takes part in the process of blood cell synthesis. Moreover, it is essential to produce DNA and RNA in erythroblasts.
Vitamin B12 and the function of the nervous system
Cobalamin influences the proper activity of the nervous system. This vitamin is responsible, among others, for the synthesis of neurotransmitters, nucleotides and takes part in building myelin sheath. In elderly psychiatric patients vitamin B12 deficiency is observed, which gives the symptoms of memory impairment, depression, hypomanic episodes or identity changes. Interestingly, psychological dysfunctions may constitute the only symptoms of cobalamin deficiency.
The role of cobalamin in metabolic processes
Vitamin B12 influences the proper course of metabolic transformations of proteins, fats and carbohydrates. Cobalamin, as a cofactor of two enzymes – methionine synthase and methylmalonyl-CoA, takes part in the transformations of methionine from homocysteine and methylmalonyl-CoA to succinyl-CoA. Moreover, it is essential for the conversion of folic acid to the bioactive form – tetrahydrofolate, thanks to which it influences the stabilization of human genome.
Summing up, Seeking Health, Active B12 5000 is a dietary supplement helping to safely complement cobalamin deficiency.
Due to the fact that it is a vitamin produced by bacteria, paradoxically, increasingly higher life hygiene may be the cause of its insufficient supply. Moreover, among the people especially prone to the deficits of this vitamin are elderly people (impaired absorption, increased risk of circulatory diseases) as well as vegans and vegetarians (low level of cobalamin in vegetable products).
Methylcobalamin is a highly assimilable form of vitamin B12. It takes part in methylation cycle and supports the work of the nervous system, while adenosylcobalamin is used in mitochondria and influences enzymatic changes. The presence of these two forms in 1 tablet makes the preparation exhibit a wide range of benefits. Vitamin B12 in the form of tablets used sublingually additionally increases the absorption of the preparation.
The dose of 2000 mcg (2 mg) of vitamin B12 may turn out to be helpful in order to complement cobalamin deficiency and reduce homocysteine level, however, in order to achieve these benefits, 4 months of supplementation may be needed. Higher doses of 3000-5000 mcg are directed at people with serious deficit of this vitamin and ailments that may contribute to impairing cobalamin absorption.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
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