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Homocystex Plus by Seeking Health is a dietary supplement containing in its composition active forms of vitamin B2 (25 mg), B6 (15 mg), B12 (1000 mcg), folate (800 mcg) and betaine TMG (700 mg), which support natural methylation processes in the organism and support proper metabolism of homocysteine.
The product contains bioavailable forms of vitamins from the group B and betaine TMG, which condition correct transformations related to the synthesis of methionine from homocysteine. The supplement is recommended to people characterized by excessively high concentration of homocysteine in blood, as a result of improper diet or mutation of MTHFR gene.
Vitamin B2 (riboflavin) is an organic chemical compound created by combining flavin and ribitol soluble in water. It is a precursor of important enzymes – FMN (flavin mononucleotide) and FAD (flavin adenine dinucleotide). It conditions proper functioning of the peripheral and central nervous system by taking part in the synthesis of the most important neurotransmitters in the brain: serotonin, gamma-aminobutyric acid and dopamine.
Riboflavin regulates the immune system, taking part in the production of antibodies produced during the immune response of the hormonal type. Along with vitamin A, it is responsible for a good state of mucous membranes, skin, mucosa of the digestive tract, epithelium of blood vessels and it also strongly affects good condition of eye ball and vision.
Vitamin B2 deficiency is related to increased changes of inflammations of mucous membrane of oral cavity and tongue, i.e. mouth ulcers, warts, oral candidiasis, angular cheilitis, breaking lips and skin dryness and also problems with hair loss, vagina infections in women, eye damages, problems with concentration and sleeplessness.
Vitamin B6 – a group of 6 chemical compounds, pyridoxine derivatives. They are pyridoxine, pyridoxal, pyridoxamine and their phosphate esters. It is stored mainly in muscles and liver in biologically active form of pyridoxal phosphate. Similarly to other B-group vitamins, it is soluble in water and takes part in important biochemical reactions in the human organism.
Vitamin B6 is responsible for proper processes of glycogenesis (the synthesis of glucose to glycogen chain for stores) and glycogenesis (the process of the breakdown of glycogen to glucose-1-phospate, taking place in muscles and liver), which are very important transformations, especially for sportsmen and physically active people. It has positive influence on the cardiovascular system – it lowers blood pressure, regulates heart work, decreases the risk of developing atherosclerosis and heart attack. It is important in the proper functioning of the nervous system, as it takes part in the synthesis of niacin from tryptophan and takes part in the production of neurotransmitters, i.e. adrenaline and serotonin.
Moreover, it takes part in transforming processes of fatty acids, especially the transformation of linoleic acid C18 to arachidonic acid C20, which is essential for the synthesis of prostaglandins – hormones responsible for regulating physiological processes.
Folate – is a compound, especially essential for pregnant women to the proper development of the fetus. Its active form is known in the form of 5-methyltetrahydrofolate (MTHF) and it is metabolized and transformed in the liver.
One of the most important functions of folate is taking part in the synthesis of nucleic acids, in which genetic DNA materials are created. Along with cobalamin, they take active part in blood-forming processes – they build erythrocytes and counteract developing anemia.
Moreover, folate takes part in the production of a very important neurotransmitter – serotonin, the proper concentration of which conditions well-being, counteracts depression and disorders in the functioning of the nervous system and helps to deal with stress.
Supplementation with the active form of folate helps in the proper functioning of the digestive system – it stimulates gastric acid secretion, supports the functions of liver, bowel and stomach. Proper concentration of folate in blood prevents developing colorectal cancer and stomach ulcers.
Vitamin B12 – is an organic chemical compound soluble in water, containing central atom in the form of cobalt. The most bioavailable forms for the organism is methylcobalamin and adenosylcobalamin, which may be easily assimilated by the organism, without any need of complicated transformations.
High amounts of vitamin B12 are contained in food of animal origin, therefore cobalamin supplementation is essential for vegans and vegetarians. It is also called the “red vitamin”, as it takes active part in the production of red cells. It regulates the work of the nervous system, takes part in the production of serotonin – a very important neurotransmitter in case of the fight with depression, irritation and anxiety disorders.
Proper concentration of cobalamin in blood helps to maintain mental ability, supports concentration and improves memory. It also facilitates the production of melatonin, a hormone with antagonist effect on cortisol, the proper concentration of which in the evening allows to fall in a deep and efficient sleep, ensuring regeneration of the whole organism. It decreases the feeling of fatigue and adds energy by its participation in the processes of transforming proteins, carbohydrates and fats. By the same token, it ensures proper energy metabolism of the whole organism.
TMG – trimethylglycine, also called betaine anhydrous, a derivative of glycine amino acid. It is used in the organism as a donor for methyl groups during the processes of transforming methionine to homocysteine, taking the form of dimethylglycine. It supports digestion, stimulating the production of hydrochloric acid in the stomach, positively influences bowel function, increases the processes of fat burning, but primarily it is used to decrease excessively high homocysteine level.
Homocysteine and methylation
Methylation is a process conditioning proper cell divisions and repairing damaged DNA cells. It provides the organism with methyl groups taking part among others in the synthesis of choline, carnitine, coenzyme Q10, myelin sheath protein, metabolism of neurotransmitters, i.e. serotonin or dopamine.
Improper methylation is most often caused by the deficiency of methyl groups of folic acids, vitamin B12 and B6, leading to impairing the processes related to detoxification of the organism, damaging DNA structure and cell aging. DNA mutations lead to the risk of creating, among others, cancer cells and neurodegenerative diseases.
Vitamin B12, folic acid and vitamin B6 play a very important role in the processes of the synthesis of methionine to homocysteine and deficits of these substances lead to impairing methylation functions in the organism, which may result in hyperhomocysteinemia – excessively high concentration of homocysteine in the plasma.
Consequences of increased homocysteine level
Proper concentration of homocysteine in blood should not exceed 10 umol/l. Higher values are called hyperhomocysteinemia.
Excessively high concentration of homocysteine leads to the creation of S-adenosylhomocysteine, a compound which lowers the number of cells of endothelium securing arterial vessels from the creation of atherosclerotic plaques. This phenomenon also causes the increase of blood pressure and the risk of stroke and heart attack.
Hyperhomocysteinemia and methylation problems lead to the disorders in the development of the fetus and problems with becoming pregnant as well as lower concentration of neurotransmitters, i.e. serotonin and dopamine, leading to the risk of developing neurodegenerative diseases and cancers.
An increasingly common phenomenon is impairing MTHFR gene, which makes it impossible to properly utilize folic acid and vitamin B12 – the organism cannot transform these substances to the proper, bioavailable form, which results in the increased amount of toxins in the organism, DNA damage and increased risk of developing civilization diseases.
People who have a faulty MTHFR gene should only take supplements containing active and methylated forms of B-group vitamins, which condition proper methylation processes in the organism and become entirely utilized.
Summing up, Homocystex Plus is a product containing the most bioavailable forms of B-group vitamins, helping in proper processes of methylation and in correct metabolism of homocysteine. An additive of TMG intensifies the effectiveness of the supplement, which becomes an ideal product to fight with hyperhomocysteinemia.
Due to the fact that B-group vitamins are soluble in water, it is recommended to take the supplement with a lot of fluids.
In case of additional supplementation with vitamins C and D, the product should be taken with a few hour break.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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|per 1 portion (1 capsule)||amount||%DV|
|Riboflavin (as riboflavin-5’-phosphate sodium)||25 mg||1923%|
|Vitamin B6 (as pyridoxal-5’-phosphate)||15 mg||882%|
|Folate (as Quatrefolic (6S)-5-methyltetrahydrofolate, glucosamine salt)||1360 mcg DFE||340%|
|Vitamin B12 (50% as methylcobalamin and 50% as adenosylcobalamin)||1000 mcg||41667%|
|TMG (trimethylglycine)||700 mg||**|
HPMC (capsule), ascorbyl palmitate, silica, and medium chain triglycerides.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
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