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Source Naturals DMG is a dietary supplement containing N,N-Dimethylglycine, also called DMG, pangamic acid and vitamin B15. The preparation demonstrates a wide array of pro-health effects in the whole organism.
DMG (dimethylglycine) was discovered by Ernest Krebs in 1951. This compound is a derivative of glycine – an amino acid, which plays a role of an inhibiting neurotransmitter in the central nervous system and it commonly appears in food, mainly high-protein products (fish, meat, milk products, legumes, pumpkin seeds). In scientific circles, dimethylglycine is considered a vitamin (B15) and although in Poland it is still not very well-known, it is gaining more and more popularity in the World. It is very popular and widely used in medicine of the countries of the former Soviet Union.
DMG takes part in many various biochemical pathways and processes taking part in the organism. It plays an important role as a donor of methyl groups, similarly to folic acid, it takes part in metabolism of homocysteine and methionine, participates in glutathione synthesis, by influencing energy extraction from glucose and lipids, it supports optimal oxygen utilization in cells, assists in neutralization of free radicals and the creation of lymphocytes – cells of the immune system.
Dimethylglycine may also to a large extent prevent fatty diseases of parenchymal organs, such as liver, reduces cholesterol level and by stimulating angiogenesis, i.e. the creation of totally new blood vessels, it influences blood supply of muscles and other tissues.
During 0,5 – 1 hours after oral application, DMG is absorbed from the intestines to the portal system and then it is metabolized in the liver, where it is transformed to monomethylglycine, N-methylglycine and glycine. The products of DMG conversions are next transported to other parts of the organism, including the nervous system.
Application in sports
Regular application of DMG may increase physical efficiency of sportsmen and people who recreationally practice physical activity. It accelerates oxidation of glucose and lipids in cells and consequently energy extraction in the process of intracellular respiration. Dimethylglycine requires the breakdown of lactic acid in skeletal muscles, thanks to which it prevents excessively early fatigue, improves concentration and in systematic application, it has supportive effect on the whole organism, especially in the periods of increased physical and mental effort. It is also believed that DMG stimulates the synthesis of phosphocreatine and thanks to this, it may intensify ATP synthesis and cause the improvement of effort parameters.
Influence on the nervous system
Dimethylglycine intensifies cellular respiration in neurons, thanks to which it mentally stimulates. DMG thanks to glycine, which inhibits motor neurons of spinal cord, has anticonvulsant effect, which makes it worth recommending to all people dealing with excessive muscle trembling (e.g. Parkinson’s disease, stress, nervous arousal) and in case of epilepsies.
General influence on the organism
DMG increases bile production and detoxification of the organism, accelerating elimination of toxins and heavy metals. In systematic and long application, the users of dimethylglycine report general improvement and stimulation of the organism both physically and mentally. They also describe the growth of immunity of the organism to fatigue, improvement of circulation and growth of the activity of the heart muscle. Apart from this, thinking processes are improved, thanks to which DMG is often recommended in the therapy of autism and dementia.
To sum up, Source Naturals DMG is a dietary supplement which may successfully be used by all physically and intellectually active people as well as those who are in the risk group of atherosclerosis and degenerative diseases. Thanks to facilitating oxygen and nutrients provision to cells, intensification of the synthesis of ATP and phosphocreatine, the preparation ensures maintaining proper level of methionine in the organism.
The administration of dimethylglycine is recommended for skin and hair diseases, states of chronic mental and physical fatigue, coronary artery disease and other cardiovascular disorders, impaired immunity, infections and autism. According to available literature, an effective daily dosage is 100-150 mg and the action of DMG is enhanced by vitamin E and A. DMG should not be taken with formulas containing strychnine or other substances with a similar mechanism of action because it blocks glycine repectors in cells, counteracts the effect of DMG and increases muscle twitching and tone.
Source Naturals is an American vitamin and herbal supplement provider, created in year 1982. The company specialize in producing nutritional formulations for the maintenance of well-being and the enhancement of life – they introduced numerous award-winning formulas, recognized for their excellence in independent surveys and nutritional analyses.
The company also provides education that empowers individuals to take responsibility for their health.
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microcrystalline cellulose, dibasic calcium phosphate, stearic acid, colloidal silicon dioxide, modified cellulose gum, and magnesium stearate.
Calories are the conventional name of the unit expressing the energy value of food, the demand and energy expenditure in human body, which in fact is 1 kilocalorie (1 kcal). 1 kilocalorie is the amount of thermal energy required to heat 1 g of water and 1 degree Celsius. The SI unit of thermal energy is 1 joule (1J), equal to approximately 4,185 kcal.
The energy value is determined by the chemical composition of the food product, by means of the so-called. physiological equivalents. Most often Atwater equivalent is used: ratio for protein 4 kcal / g, for carbohydrates 4kcal / g, and for fat - 9kcal / g.
The energy value carried out with the so-called. "Caloric bomb" is equivalent to the physical energy, amounting to 4.1 kcal per 1 g carbohydrate to 5.65 kcal per 1 g protein, 9.45 kcal per 1 g of fat.
Nutritional value, determines the suitability of a food product for realizing life functions of human, the higher it is - the higher bioavailability and lower quantity for consumption for obtaining the effects.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
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