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ALINESS Natural Ashwagandha 9% is a supplement containing a standarised Withania somnifera extract. Withanolides, alkaloids and withaferin A contained in the plant display great biological activity: they have adaptogenic, antioxidant, and neuroprotective properties. Every capsule contains as much as 600 mg of the ashwagandha extract.
Ashwagandha (Withania somnifera) – also known as Indian ginseng, a bush growing to the height of up to 150 cm, found mainly in India but also present in Iran, Pakistan, and Africa. The plant has yellow-and-green flowers and dark orange fruit which, along with the root, are used the most frequently for medicinal purposes. The plant has been used in Ayurvedic medicine for thousands of years as a vitality-enhancing and stress resistance-increasing agent.
The biological activity of ashwagandha stems from the content of the following substances: withanolides, alkaloids, glycowithanolides, phytosterols, and the best-tested withaferin A. This supplement is a Withania somnifera extract in the ratio of 4:1, standardised to the content of 8% withanolides, 1% alkaloids, and 0.5% withaferin A.
The modern lifestyle, pursuit of career, working at night, and highly processed foods are all stress factors whose effects on the organism and significance have highly increased in recent years. Long-lasting and chronic or frequent stress, regardless of its origin, has negative effects on the body, as it triggers defence mechanisms. The organism responds with a burst of corticosteroids and neurotransmitters that prepare it for fighting danger. As an adaptogen, ashwagandha reduces the negative consequences of stress in the organism and helps it to adapt to stressful conditions. Glycosides contained in the plant reduce the production of the main hormone in reactions to stress, cortisol, by stimulating GABAergic receptors in the hypothalamus. Gamma aminobutyric acid is an inhibitory neurotransmitter, and stimulating its receptors hinders the transmission of action potentials and information in the nervous system.
The plant also has the ability to sensitise serotonin receptors (5-HT), facilitating the binding of serotonin with its receptors, and improves the mood without affecting serotonin levels. Moreover, ashwagandha reduces the activity of neuronal nitric oxide synthase (nNOS) and the action of glutamate, which are responsible for excessive stimulation during a stress response.
Support for the protective barrier
Chronic inflammation or excessive oxidative stress in the organism can lead to the development of such diseases as type 2 diabetes, cardiovascular diseases, or autoimmune diseases. Ashwagandha stimulates the immune system, increasing the levels of natural killer cells and T lymphocytes as well as promoting the proliferation of macrophages and increasing their activity. What is more, withanolides contained in the plant have an antioxidant effect, which means that they protect the organism from the negative action of free oxygen radicals.
Ashwagandha also exhibits protective properties in the central nervous system (CNS), where it affects serotonin receptors 5-HT2 and, consequently, reduces the level of nNOS, which prevents excess corticosterone levels. Corticosterone has similar properties to cortisol, and its high amounts in the CNS can contribute to memory deterioration. A reduction in glutamate levels, which was mentioned before, prevents excessive stimulation of nerve cells, which can have an excitotoxic effect and damage or destroy neurons.
Neurogenesis is the process of new nerve cell formation. More connections between neurons improve communication between them and have a positive effect on cognitive functions. Ashwagandha stimulates the formation of dendrites, which receive the information coming from the endings of other neurons, which enhances communication in the brain. Moreover, the plant supports the proliferation of astrocytes, which participate in the formation of the blood-brain barrier, improve communication between neurons, and nourish nerve cells.
The plant increases the level of the brain-derived neurotrophic factor (BDNF), which promotes the growth and differentiation of neurons and synapses. The greatest activity of the factor can be observed in the hippocampus, the part of the brain responsible for the storage of memory traces. What is more, ashwagandha reduces and inhibits neurodegenerative lesions and can prove helpful in Alzheimer’s and Parkinson’s diseases.
To sum up, ALINESS Natural Ashwagandha 9% is a highly-standardised extract containing a large amount of the most active substances contained in the plant Withania somnifera. The plant is a powerful adaptogen: it helps the organism to adapt to stressful conditions and eliminates the negative effects of stress on the body, such as the deterioration of cognitive functions. Ashwagandha supports the functioning of the immune system as well as exerts antioxidant and neuroprotective effects on the CNS. It is recommended particularly for people who suffer from chronic stress or excessive response of the organism to stress factors.
The dosage of 600 mg contained in the preparation ensures that the desired effects of supplementation can be achieved with just 1 capsule; however, people with high exposure to stress can take 2 capsules daily.
Ashwagandha has a calming and sedative effect, so it is recommended to use it in the evening, preferably before bedtime.
In order to reinforce its effects, it can be combined with other adaptogenic herbs, such as Rhodiola rosea, ginseng, or ginkgo biloba.
The supplement can interact with some immunosuppressant drugs, antidepressants, and hormones increasing thyroid hormone function.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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Capsule shell: (hydroxypropylmethylcellulose).
The product without GMOs, does not contain gluten, lactose and soy.
Ashwagandha (Wythania somnifera / Indian ginseng) - a plant of the nightshade family, used in Oriental medicine as a means of adding vitality, improves the psychophysical condition. It is used as an aphrodisiac. The root of the plant is a rich source of bioactive compounds (phytosterols, glycosides, withanolides etc.). The sports supplementation, herbal preparations, a positive effect on the nervous system (reduces stress, and accelerates the adaptation to changing conditions psychophysical), hematopoietic and immune systems. It has a decisive influence on the process of synthesis of nitrogen oxides and the level of certain hormones, including testosterone (e.g. improving sexual functions).
Ashwagandha (Withania somnifera) is a component of the complex herbal supplements (as well as sets of adaptogens) increase the level of the male sex hormone (testosterone), supporting the sexual function of the body, supporting regeneration and having a calming effect.
Dosage: 300-600 mg of extract per day.
Withanolides - biologically active compounds belonging to the group of steroid lactones, occurring in some green plants. In supplementation they are perceived mainly as active substances of Withania somnifera, commonly called Ashwagandha. The percentage content of withanolides in Ashwagandha extracts is considered the indicator of the product’s quality - the higher the content, the more effective the supplement. In non-standardized extracts, the content of withanolides is estimated for 1% of dry muscle mass of Withania somnifera leaves.
Being the main active substances of Ashwagandha, withanolides are responsible for the majority of effects of its application. Regular supplementation with Withania somnifera extracts demonstrates adaptogen effect. It increases the organism’s tolerance to stress factors, holistically promoting the functions of the organism. It may decrease cortisol level in case of its excessively high concentrations, promote cognitive abilities and facilitate concentration. Supplementation with Ashwagandha also supports maintaining proper daily rhythm and is conducive to falling in a deep sleep.
Some sources also indicate that supplementation with Withania somnifera extracts positively influences the level of testosterone in the organism. Current research results indicate, however, that this effects of supplementation may be achieved only in people with initially excessively low secretion of the male sex hormone.
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