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Life Extension Optimized Ashwagandha Extract is a dietary supplement containing the highest quality, patented extract of Sensoril® Withania somnifera standardized to have a content minimum 8% of withanolides and 32% of oligosaccharides. This is the most balanced ratio of active ingredients contained in the extract, which distinguishes this product from others ineffective preparations.
Ashwagandha (Withania somnifera) – a medicinal plant used in traditional Eastern medicine, called "Indian ginseng" due to its adaptogenic properties, ie. increasing the body's resistance to stress factors, mood stabilizing, and regulating the functioning of the immune system.
In ayurveda it is regarded as a cure for rheumatism, exhaustion, sexual impotence, and memory impairment. It contains many biologically active substances, including nicotine alkaloids, beta-sitosterol, withanolides (including withanolides D) coumarin, and chlorogenic acid.
Properties of the active ingredients
Withanolides are pharmacologically active compounds having the typical structure of steroids naturally occurring in a root of the plant. Together with withapherine A it shows antioxidant, anti-stress, adaptogenic, sedative, anti-cancer, cytotoxic, lowering blood pressure, and toning properties, improving mental work of the brain, as well as neurotonic, sexually stimulating, anxiolytic, and anti-inflammatory properties.
In addition, Ashwagandha extracts are characterized by antifungal (against black mold, Candida albicans), and antibacterial activity (against Staphylococcus aureus).
The mechanism of Ashwagandha’s action
The mechanism of action of this plant is broad, complex, and not completely understood. It has been shown that the active compounds have a high affinity for GABA and serotonin, and therefore they strengthen GABAergic and serotoninergic transmission. Through the influence of specific neurotransmitters, it regulates hormone levels, ie. cortisol, LH, FSH, prolactin, and consequently – testosterone.
Reduction of fears and anxiety
Anxiolytic properties of Ashwagandha were confirmed by randomized clinical trial of double blind and placebo-controlled methods in patients suffering from anxiety. The dosage was 500 mg extract withania somnifera per day in two divided doses.
Improvement of fertility in stressed men
Excessive and chronic stress is considered to be a causative factor of male infertility. On the other hand, ashwagandha in Ayurvedic medicine is used as a preparation suppressing the symptoms of stress and resistance to incentives exerting it. Accordingly, the goal of the researchers was to investigate whether the plant will help to improve fertility in men.
The surveyed representatives of the male received 5 grams per day of powdered root of Ashwagandha for a period of three months. The therapy resulted in a reduction in feelings of stress and performance, strengthened the antioxidant system, and improved the quality of sperm in most men.
Ashwagandha raise the level of antioxidant enzymes in the organism: superoxide dismutase (SOD), and catalase, that neutralize reactive oxygen species (ROS). It should be noted that SOD catalyzes the dismutation of superoxide anion radical O2, while the catalase allows the decomposition of hydrogen peroxide H2O2 to water and oxygen.
In addition, there was also noticed a significant increase in the level of vitamins C, A, E, reduced glutathione (GSH) level in the blood, an increase in a testosterone level (approx. of 10-22%) and LH (approx. of 5-20%), reduction of cortisol (approx. of 36-48 % at 16 o'clock).
Resistance to stress
Ashwagandha is widely used as a sedative, calming and bringing healthy sleep preparation. This allows the organism to adapt to stress factors – thanks to that it returns to homeostasis, despite the impact of stressors. It restores a dysregulated body to function properly, despite a poor diet, lack of sleep or physical, or mental fatigue.
Withania somnifera is widely appreciated primarily for its action improving mood, anti-stress, anxiolytics, antidepressants, improving adaptation to the environment, increasing self-confidence, extroversion, and openness to new experiences properties.
It owes its properties thanks to the ability to sensitize serotonin (5-HT), whereby the same amount of serotonin, by binding to a specific receptor, works stronger, and more efficient.
Life Extension Optimized Ashwagandha Extract is a dietary supplement recommended especially for people living in constant stress, overworked, tired, having trouble with sleeping, and of well-being. Due to lots of pro-health characteristics it is used to encourage the cardiovascular and immune system, and to improve the working of thyroid, and blood parameters.
It is believed that 300 mg (1 capsule) of Ashwagandha is enough to increase immune system and adaptation capacity. At higher exposure to stress higher doses are recommended - 600 mg (2 capsules). Ashwagandha has a calming and sedative effect, this is why the product is recommended to use especially for the night. For substances with adaptogenic effects, we recommend to replace the product every two months. And also it is not recommended for use with sedative drugs.
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|per 1 capsule||amount||%RDA|
|Sensoril® Ashwagandha extract (root and leaf) [std. to 32% oligosaccharides, 10% withanolide glycoside conjugates]||125 mg||*|
rice flour, vegetable cellulose (capsule), maltodextrin, vegetable stearate, silica
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