• Patented extract from grapes and blueberries
• High concentration of bioavailable flavonoids
• Prevention of neurodegenerative diseases
• Delays brain ageing by up to 10 years
• Reduces brittleness of blood vessels
• Improves short- and long-term memory
• Unbeatable biochemical profile
• Increases capacity of working memory
• Scientifically proven effectiveness
• Complex of strong antioxidants
• Seals blood vessels
• Highly standardised extract
• Synergistic ingredients action
• Supports learning processes
• Increases brain plasticity
• Reduces blood pressure
• Reduces memory deficits
• Stimulates brain functions
• Improves blood circulation
• Anti-inflammatory properties
• Improves neurogenesis

Hepatica Memophenol™ is a dietary supplement which contains a patented extract from grape and blueberry fruits, standardised for the content of flavonoid compounds. They form a unique composition characterised by the above-average biochemical profile and the highest possible bioavailability. Numerous studies confirm its procognitive and therapeutic properties and ability to improve memory.

The product was designed to improve cognitive vitality and functions as well as to inhibit memory deterioration. It is recommended for white collar workers and people exposed to large intellectual effort. It can be used by pupils and students, who want to accelerate and improve effectiveness of knowledge acquisition, as well as for elderly people, concerned about memory deficits which appear with time.

Because of the therapeutic properties of flavonoids, the supplementation is intended for people being at risk of high blood pressure and suffering from vascular failure of lower limbs. The product is a valuable element of the prevention of chronic diseases, especially those associated with brain cells atrophy.

Common grape vine (Vitis vinifera) is native to south Europe and west Asia. Its fruits, the popular grapes, contain many valuable, pharmacologically active components, including flavonoids, polyphenols, proanthocyanidins, procyanidins and stilbenes. Grape extracts have wide spectrum of pharmacological and therapeutic effects. They are strong antioxidants, inhibit inflammations and shows antibacterial, cardioprotective and neuroprotective properties.

Lowbush blueberry (Vaccinium angustifolium) is a species of blueberry, native mainly to Canada and the north-eastern USA. It has small, sweet, dark blue berries which are popular and keenly consumed also in Poland. Because of the richness of flavonoids, lowbush blueberry was studied by researchers, and its extracts are gaining popularity as health-promoting agents. It is recommended especially within prevention of cardiovascular and neurodegenerative diseases.

Memophenol™ is a unique and patented extract from common grape vine and lowbush blueberry, standardised for the content of flavonoids. Flavonoids are not equally bioavailable and their action is not the same. Memophenol™ contains only bioavailable flavonoids and these which have the strongest influence on cognitive functions.

Also the fruits weren’t selected randomly. Studies have proven that four active compounds isolated from lowbush blueberry, combined with monomers extracted from grapes are three times better absorbed than when applied alone or in combination with substances from other extracts. Synergistic action of product components results in its extreme effectiveness and power.

Mechanism of action and benefits for cognitive health
Long clinical studies in elderly people gave surprising results. It turned out that regular consumption of polyphenols can reverse brain ageing by up to 10 years. People taking Memophenol™ have similar memory and mental efficiency in all cognitive tests as people 10 years younger.

Flavonoids contained in the product are able to cross the blood-brain barrier. After reaching the target organ, the brain, they positively affect a range of parameters associated with memory and cognitive functions. Their mechanism of action affects the four main parameters.

Flavonoids stimulate brain plasticity. It is a characteristic of neurons, which means an ability to create new communication paths between them. It is crucial not only for the repair and compensation of damages in the nervous system, but also affects information acquisition, memorising, facts association and adjusting to new situations. Synaptic plasticity is modulated by the activity of genes regulated by CREB, a cellular transcription factor. Studies have demonstrated that flavonoids can affect activation of CREB protein.

Flavonoids stimulate neurogenesis. It is a process of forming new nerve cells in the brain and rebuilding dendritic trees, which is of great importance for learning and memorising. Great number of properly functioning neurons facilitates acquisition of complicated information and efficiency of intensive mental effort.

Flavonoids improve microcirculation. They are known for its positive influence on the condition of arteries and blood vessels. They prevent brittleness, strengthen and seal the wells and improve condition of endothelium lining the vessels. These all result in the proper vasodilatation and smooth circulation. In turn, this is essential for supplying the brain with oxygen and nutrients, e.g. glucose. Only well nourished and properly oxygenated brain can work quickly and effectively.

Flavonoids show antioxidant properties. By maintaining the proper balance between oxidation and reduction, they prevent the formation of excessive free radicals and protect the neurons from damage caused by oxidative stress. Impaired oxidation-reduction balance within the brain is particularly dangerous. Depending on its intensity, it has various symptoms, including memory deterioration and decline in mental performance. The worst cases result in neurons death and development of severe neurodegenerative diseases. Antioxidants not only play an important role in the therapy and prevention of neurodegenerative diseases, but can even change the disease course.

Health-promoting properties
Flavonoids show hypotensive properties. They affect the main factors responsible for the proper blood pressure; they improve circulation, stimulate the functions of endothelium cells in the blood vessels and stimulate synthesis of nitric oxide.

Flavonoids can be helpful for people suffering from vascular failure of lower limbs. They strengthen and seal blood vessels, improve condition of arteries and capillary vessel. They prevent excessive aggregation of blood platelets. Thus, they ensure the proper venous circulation.

Flavonoids show hepatoprotective properties. They protect the liver from oxidative damage, reduce ischaemia and stimulate regeneration of hepatocytes.

Flavonoids reduce the risk of atherosclerosis and cardiovascular diseases. They improve blood supply to the heart, reduce cholesterol level and prevent blood clots.

To sum it all up, Memophenol™ is a revolutionary dietary supplement which allows achieving over-average results in case of memory and cognitive functions improvement as well as improves general health. It is perfect in periods of increased mental effort, before exams, tests or when there is a need of acquiring great doses of information. The product can be also recommended for seniors, in whom memory deficits are a natural consequence of time.