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pTeroPure Pterostilbene is a dietary supplement, which contains pterostilbene – a unique compound of plant origin with a very interesting mechanism of activity and incredibly wide scope of pro-health properties. It may be used to increase intellectual potential and memory and to protect the organism from negative aging effects. In clinical research it was proven that its effectiveness is connected to many metabolic diseases (e.g. diabetes) as well as hematological, neurological, carcinogenic diseases and those related to the circulatory system.
The producer guarantees the highest quality of the product – there is pTeroPure in its composition, i.e. the original pterostilbene, used in clinical trials, simultaneously being one of the licensed materials approved for usage in supplements in high doses.
Pterostilbene (trans-3,5-Dimethoxy-4'-Hydroxystilben) belong to the group of phytoalexins, i.e. substances produced by plants in response to the pathogens’ attack (bacteria, fungi, mold). It is structurally similar to resveratrol, as it is its di-methylated analogue, i.e. instead of hydroxyl groups, it has two methoxyl groups. Thanks to this it is distinguished by significantly higher assimilability and pharmacological activity and by the same token it exhibits much higher effectiveness.
Natural pterostilbene appears mainly in berry fruits – grapes, bilberries, blueberries. It may also be found in the Indian tree – Malabar kino. However, in food products of plant origin pterostilbene appears in trace amounts. In order to fully take advantage of its therapeutic effect, you should take considerably higher doses that cannot be obtained from natural sources.
Anti-inflammatory effect and protection against oxidative stress
Chronic inflammations, often called a silent killer, are conditioned by organism aging and are an intermediate cause of many serious diseases. Oxidative stress is also extremely dangerous and it contributes to vessel damages, oxidation of “bad” cholesterol (LDL fraction) and consequently it leads to the development of arteriosclerosis and circulatory system diseases.
Oxidative stress also conditions premature aging of the organism with all its health consequences. It may also provoke pathological changes in cells, leading to developing cancer. Anti-inflammatory and antioxidative properties of pterostilbene protect cells from damages and help to maintain health.
The mechanism of activity of pterostilbene is connected to blocking the production of prostaglandin PGE2 – a tissue hormone, the main pro-inflammatory mediator. Moreover, it precludes excessive release of sphingosine kinase and phospholipase D – the two enzymes being the main cause of inflammations in the organism.
Pterostilbene fights one of the main causes of cell damages – free radicals. It inhibits the activity of cyclooxygenase enzyme (COX-1), responsible for a range of oxidative stress symptoms, simultaneously increasing the expression of important antioxidative enzymes, to which there belong: glutathione peroxidase (GPx) glutathione reductase (GR), glutathione (GHS), superoxide catalase and dismutase (SOD). Maintaining the balance between these enzymes influences homeostasis balance in the organism and constitutes one of the most important elements of antioxidant protection.
Regulating metabolic functions thanks to modulating gene expression
One of the most interesting mechanisms of pterostilbene’s activities is the ability to modulate gene expression, i.e. the potential to change messages that genes transmit to the system.
Clinical research proved that pterostilbene precisely imitates, on the molecular level, the desired effects of calorie restriction. Scientists agree that restricting calories activates genes responsible for longevity, regulates various metabolic functions and inhibits the activity of factors causing cancers. Pterostilbene modulates exactly the same genes as calorie restriction.
It is conducive to increasing the activity of complexes sensitive to fat, thanks to which it lowers lipids in blood. It contributes to the improvement of the cholesterol profile, especially regarding LDL fraction (the so-called “bad cholesterol”).
The imitation of calorie restriction by pterostilbene allows to regulate sugar level in blood. It increases insulin sensitivity and helps to modify enzymes important for regulating glucose level. It lowers the level of glycated hemoglobin (marker of glucose homeostasis disorders).
Pterostilbene, similarly to other stilbenes (e.g. resveratrol), influences the activation of proteins from the family Sir3, i.e. sirtuins. They are responsible for metabolism and regulating aging processes. In the course of research it has been proven that by imitating calorie restriction, pterostilbene directly increases the activity of sirtuin-1 protein, coded by the gene SIRT 1, which by operating in mitochondria, influences proper functioning and condition of cells.
Thanks to unspecific effect of pterostilbene, it is also possible to lower sensitivity and frequency of genetic transmission, preventing apoptosis (programmed cell death), as well as limit the ability of particular cancer cells to spread. By the same token, pterostilbene seems to be crucial to minimize unfortunate effects of aging and constitutes a perfect element of carcinogenic diseases prophylaxis.
Improvement of memory and cognitive functions
Pterostilbene contributes to memory improvement, increases brain neuroplasticity and brings many benefits to mental health. Contrary to other antioxidants, it assimilates well and may cross blood-brain barrier. Thanks to this, by working directly in the brain area, it is able to neutralize cell dangers considerably better.
Pterostilbene controls dopamine level and prevents its loss, an important neurotransmitter engaged in regulating the nervous system. By the same token it contributes to the general improvement of mood, the increase of energy level and motivation.
Pterostilbene also contains a few mechanisms of cognitive functions improvement. It supports memory thanks to activating brain proteins responsible for cell signalization. Research on rodents proved that pterostilbene supplementation considerably improved their results in cognitive and motor tasks. These effects may be especially associated with the growth of the production of IGF-I peptide (insulin-like growth factor), natural protein influencing blood vessels and neurons growth in the area of hippocampus and significantly improving memorization.
Weakening cognitive functions seem to be a natural consequence of organism’s aging. However, research showed that cognitive functions do not have to decrease with age if we manage to maintain a healthy neurological tissue. A huge role is played by pterostilbene, which, by means of complicated mechanisms, protects brain cells before dying, reduces dangerous inflammations, decreases negative effects of oxidative stress and modulates genes responsible for longer life.
Pterostilbene is a preparation with a wide spectrum of pro-health properties. It is based on a natural substance with a scientifically proven effect, which guarantees effectiveness and safety of use. Regular supplementation may contribute to the improvement of memory and cognitive functions, slow down aging processes of the organism and protect us against many ailments that stem from chronic inflammations and oxidative stress.
The recommended daily dose of pterostilbene usually ranges from 50 to 250 mg. However, it is advised to start the supplementation from a lower dose and then gradually increase it. It is best to divide the dose into two portions – one in the morning and the second in the afternoon.
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|per 1 capsule||amount||%DV|
|trans-Pterostilbene (from pTeroPure)||50 mg||**|
microcrystalline cellulose, vegetable cellulose (capsule), silica, stearic acid.
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