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Thorne B-Complex #12 is one of the most popular and the most strongly concentrated vitamin dietary supplements from one this producer. It offers the full complex of B-group vitamins soluble in water, with an additive of choline, essential for the proper functioning of almost all parts of the body.
New, refined formula was designed on the basis of compounds and chemical combinations with high solubility, which leads to their effective absorption. Certain vitamins appear in one or a few active forms. In the majority, they do not require further transformations to obtain their full biological activity and thanks to this they maximally increase bioavailability of the product. The assimilability of vitamin complexes is especially important and their deficiencies may occur even in case of applying the doses exceeding the recommended norms.
Vitamins in the composition of the preparation are responsible for a range of the following functions:
Vitamin B1 (thiamine hydrochloride) - regulates sugar metabolism in the organism, is the component of enzymes, mainly decarboxylase α-keto acids and transketolase, taking part in the transformations of carbohydrates. It actively takes part in energy and neurophysiological processes and enables the transmission of nerve impulses. It is essential for regulating the work of heart and muscle tissue. Supplementation is especially recommended in case of large consumption of tea and coffee.
Vitamin B2 (as riboflavin and sodium salt of riboflavin 5’-Phosphate) - necessary for the proper growth, supports anabolic processes in adults and children. It takes part in the metabolism of all macronutrients (carbohydrates, fats and proteins). It plays an important role in the functioning of the eyesight, the immune system and its deficiencies are visible very quickly and they may be observed in skin lesions (angular cheilitis and seborrhea).
Niacin (as niacinamide) - conditions proper work of the central and peripheral nervous tissue. It is essential in the enzymatic synthesis of sex hormones and the remaining steroid hormones as well as thyroxine and insulin. It is an ingredient of coenzymes for all metabolic processes. Its influence on the level of cholesterol was proven - supplementation with niacin leads to the decrease of the concentration of LDL fraction. Additionally, it enables proper regeneration in epithelium, both of epidermis cells and mucous membranes.
Folates (as calcium folate and L-5-methyltetrahydrofolate) - play a role in the development of cells of the organism, as a cofactor of enzymes synthesizing nucleic acids. They are necessary to carry out hemopoiesis and to produce hormones: adrenaline, noradrenaline, thyroxine and melanin. They unconditionally need to be present as an element of supplementation of pregnant women, as they decrease the risk of neural tube defect in the fetus.
Contrary to commonly used folic acid, folates, as methylated derivatives do not undergo enzymatic liver biotransformation, at the same time demonstrating full catalyzing activities, directly after being absorbed from the digestive system.
Vitamin B6 (pyridoxine hydrochloride with pyridoxal 5′-Phosphate) - this vitamin also influences metabolic transformations of the organism, regulating glycolysis and gluconeogenesis. It constitutes a cofactor for more than 100 enzymes and without its participation basic physiological process do not take place. It is necessary to produce catecholamines and serotonin. Its deficiencies develop faster in people who consume numerous high-protein products.
Along with folates, they have important influence on the synthesis of heme and erythrocytes, at the same time enabling proper transformation of homocysteine, inducing rapid decrease of permeability of blood vessels resulting from atherosclerosis.
Vitamin B12 (adenosylcobalamin and methylcobalamin) - plays the most important function by regulating the development and differentiation of cells of bone marrow. In case of its deficiency, disorders of menstrual cycle take place and pathophysiological menstrual bleedings. It intensifies neuroprotective processes, enabling proper functioning of the central nervous system. Its deficiency is often observed among people on a vegetarian diet, in such a case it i especially important to take care of proper supplementation.
Biotin - it is primarily a coenzyme of carboxylases, catalyzing metabolic transformations and anabolic reactions. These enzymes influence proper functioning of bone marrow, hair and skin. This vitamin takes part in the processes of prothrombin synthesis, inducing the coagulation cascade and regulates the glandular secretion of thyroid and pancreas.
Vitamin B5 (calcium pantothenate) - as an element of coenzyme A, it takes part in the transformations of proteins, fats and carbohydrates and it is also essential in the reactions providing energy for the synthesis of many compounds, including cholesterol, hormones, phospholipids, neurotransmitters, antibodies. It additionally regulates the synthesis of fatty acids and influences regeneration of skin and nails.
Choline citrate - is a substrate in the biosynthesis of the basic neurotransmitter of the cholinergic system: acetylcholine. Its deficiencies give symptoms of clear slowing down of neuronal transmission and then sudden decrease of concentration and memory. It is a component of membrane phospholipids of cells, has hepatoprotective properties and prevents the development of atherosclerosis.
To sum up, Thorne B-Complex #12 is a complete vitamin preparation, which is focused of bioavailability and the consumer’s expectations. It was designed for the wide age rage, therefore its application is recommended both to younger and older persons.
In case of supplementation with the complex of B-group vitamins, regularity is extremely important, therefore we need to take care of regular times of application. The dose may be increased or decreased depending on the recommended norms for a given sex and age group. Vitamins from this group absorb well in acidic pH and in the conditions corresponding to their natural intake with food, therefore each dose needs to be taken after a meal, which stimulates the secretion of gastric juices.
Thorne Research is a company that since 1984 has been engaged in the production of the highest quality dietary supplements based on innovative recipes. Thorne Research in cooperation with other leaders on the market also produces pharmaceutical, therapeutic and medical preparations.
Thorne Research offers a wide range of products that are trusted worldwide by professionals in the healthcare sector. The activity of the products has been confirmed by numerous clinical tests. The company also has GMP, TGA and NSF certificates, which demonstrates compliance with relevant standards related to the production and safety of use.
The manufacturer constantly raises the bar and focuses on continuous development and improvement of the products by implementing the latest technological solutions and employing top-class specialists.
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|per portion (1 capsule)||amount||%DV|
|Thiamin (as Thiamin HCl)||40 mg||3,333%|
|Riboflavin (25 mg as Riboflavinand 3.6 mg as Riboflavin 5'-Phosphate Sodium)||28.6 mg||2,200%|
|Niacin (as Niacinamide)||80 mg||500%|
|Vitamin B6 (20 mg as Pyridoxine HCl and 3.4 mg as Pyridoxal 5'-Phosphate)||23.4 mg||1,376%|
|Folate (400 mcg as Calcium Folinate and as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)||668 mcg DFE||167%|
|Vitamin B12 (as Methylcobalamin)||600 mcg||25,000%|
|Pantothenic Acid (as Calcium Pantothenate)||45 mg||900%|
|Choline (as Choline Citrate)||14 mg||3%|
Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide.
Vitamin B1 (thiamin, vitamin B) improves mental alertness and strengthens the nervous system ensuring the proper functioning of the brain. It improves cardiac and muscular system. It is suportive in the treatment of shingles. Involved in the metabolism of carbohydrates and fats. Natural source of vitamin B1 are brown bread, yeast, eggs, raw vegetables, meat, milk, legumes, cheese.
Vitamin B1 deficiency hinders the processes of decomposition of sugars (catabolism), causes a loss of appetite and disorders in the functioning of the digestive tract, can cause polyneuritis and disease beriberi.
Dosage: Recommended daily intake is 1-2 mg.
Thiamine hydrochloride - a highly bioavailable form of thiamine, also called vitamin B1. Due to an important role that it plays in carbohydrate metabolism, its increased supply is recommended to people with excessively high concentration of sugar in blood. It facilitates their processing in the organism and supports the activities that aim at restoring optimal glycemia. An important role in the metabolism of nutrients is also played by an integral component of carboxylase coenzyme - thiamine pyrophosphate.
Some source suggest the effectiveness of thiamine in relation to the health of the cardiovascular system, apart from decreasing glucose level in blood, it is also reflected in optimization of blood pressure. Although this aspect of effectiveness of vitamin B1 requires further research, it is another argument demonstrating special needs of taking care of proper thiamine supply by people from the risk group of the circulatory system diseases.
Among people who are especially prone to vitamin B1 deficiencies there are also people fighting with excess weight and frequently drinking alcohol.
Vitamin B2 (riboflavin) is soluble in liquids, is involved in the metabolism of proteins, fats and carbohydrates. Required for growth of the organism. Takes part in the production of erythrocytes (red blood cells). It is located in natural foods, such as yeast, meat (especially liver, kidney, heart), milk, fish and green leafy vegetables.
A deficiency of vitamin B2 inhibits the growth, diseases of the mouth, loss and greasy hair, seborrhea and stratification of nails. Increases skin roughness and susceptibility to acne and oily skin.
Dosage: 1-2 mg per day.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Vitamin B3 (vitamin PP, niacin, nicotinic acid, nicotinamide) is niacinamide niacin. It is used in interaction with vitamins B1, B2 and B6 in the synthesis of hormones during lactation. It provides proper functioning of the brain and nervous system. It is helpful in inflammatory conditions of the skin. Required for synthesis of sex hormone, estrogen, testosterone, cortisone, and insulin. It does not lose its properties in the manufacturing and storage. The source of acquiring vitamins PP are both products of animal origin (the lean meat, eggs, fish) and vegetable origin (dates, figs, hazelnuts, plums).
Dosage: 2-12 mg / day for children, 14 mg / day for women, 16 mg / day for men and 17-18 mg / day for pregnant or nursing women.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Folic acid - also known as vitamin B9, is a synthetic form of naturally occurring folates. It needs to be transformed to folates in order to be biologically active also in the human organism. Therefore, its supplementation is recommended to people who do not have problems with methylation processes.
The majority of people associate folic acid with the period of pregnancy. It is definitely a justified association. Proper supply of vitamin B9 conditions correct development of the fetus and prevents disorders of neural tube defects in a baby.
Supplementation with folic acid also demonstrates positive influence on the functions of the nervous system of adults. Some sources say that it is conducive to maintaining beneficial emotional states. Moreover, folic acid takes part in the process of erythropoiesis, thanks to which it enables efficient production of red cells.
Supplementation with folic acid should be also considered by men who deal with low sperm quality. It was proven that complementing the level of vitamin B9 is conducive to increasing reproductive abilities of men.
Calcium folinate - a metabolite of tetrahydrofolic acid constituting a perfect form of its supplementation. Tetrahydrofolic acid is a biologically active form of folic acid, especially recommended to people dealing with methylation disorders. Folic acid in the active form is at the same time a promotor of this process, but it requires efficient action for its activation, therefore in case of methylation disorders, folates are the only effective form of supplementation of this compound.
Folic acid is mainly associated with pregnancy. In its active form, it is responsible for the regulation of the development of the neural tube of the fetus, which constitutes a key factor, conditioning its proper development. Providing folates is currently indicated as the most effective form of healthy pregnancy prophylaxis.
Another important aspect of the functionality of tetrahydrofolic acid in the organism is its role in the process of methylation. It positively influences the efficiency of transformations of homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. The efficiency of this process is also conducive to maintaining the high concentration of S-adenosyl methionine in the organism. This compound demonstrates special influence on maintaining optimal mental functions and healthy liver.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Vitamin B12 (cobalamin, cyanocobalamin) is a vitamin soluble in liquids. Participates in the production of red blood cells and is essential in the absorption of iron by the body. It calming effect, a positive effect on concentration and memory. Intensifies its action in cooperation with folic acid (vitamin M). Usually occurs in animal products, fish and dairy products. It contains trace elements.
Vitamin B12 deficiency can lead to pernicious anaemia, general and immunity weakness, inhibiting of growth and damage to the myelin sheath of nerves.
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
Vitamin B5 (calcium pantothenate, pantothenic acid, pantotenol) is part of a complex of B vitamins affects the development of the central nervous system, is the building substance of cells. In the body synthesized by the intestinal bacteria. It occurs in animal products (meat, kidneys, liver) and plants (wheat germ, wheat bran, nuts, grains, green vegetables). Prevents fatigue and excessive stress, accelerates the healing of cuts and wounds, acts as a stimulant for the side effects of the use of antibiotics. Deficiency causes skin changes, and difficulty in blood clotting.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Choline belongs to the soluble in liquids group of B vitamins. It is an organic nitrogen base containing lecithin, and acetylcholine. Together with inositol is involved in the metabolism of fats and cholesterol metabolism, preventing its accumulation on the walls of arteries and deposits in the gallbladder. With the penetration of the brain, contained lecithin improves its action and improves memory. Used in the treatment of age-related diseases (Alzheimer's). It occurs in plant foods: yeast, wheat germ, lecithin, green leafy vegetables and egg yolks.
Choline citrate is a combination of choline with a derivative of citric acid. It is a new form of choline which comprises about 51% of this substance. This means that 1 g of choline citrate corresponds to about 500 mg of choline. Because of that, it contains more choline than e.g. bitartrate.
Choline citrate does not only provide choline but also has one of acetyl groups necessary for the production of acetylcholine – the main neurotransmitter in the central nervous system that is extremely important for normal thought processes and supports cognitive functions.
Choline citrate is combined usually with a more sweet ingredient to neutralise its sour taste. It is available in the form of monopreparations and also as a component of multi-ingredient dietary supplements targeted at improving focus, motivation and psychomotor skills.
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