• The form independent of complications of methylation processes in the organism
• The form quickly metabolized to other active forms
• The highest quality folinic acid in an effective dose
• Supports the processes based on DNA translation
• Demonstrates antidepressant effect
• Has neuroprotective properties
• High bioavailability

Seeking Health Folinic Acid is a dietary supplement providing the organism with folinic acid in the form of calcium salt; a metabolically active form of vitamin B_9. This form demonstrates high, more than 90% bioavailability and may be quickly metabolized to other forms, mainly L-methylfolate (the metabolism of which is bilateral; the excess of methylfolate may be retransformed to folinic acid).

Folates, folinic acid, folic acid, methylfolate – what is the difference?
We should clearly highlight the differences between the concepts of folates, folinic acid, folic acid and methylfolate, as similar names may be confusing. Folates stand for the name of the group of compounds demonstrating analogous features to folic acid. Folates include various compounds, i.a. folic acid, folinic acid and methylfolate.

Folic acid is the most basic form of folates, however, it is not directly used by the organism. It needs to undergo proper metabolic processes, which is indicated as its fault, as we need to remember about the loss of the active substance, in each subsequent metabolic process (in other words, it is not very metabolically active). A final product of the cycle of folates is methylfolate, taking part in the processes of methylation in the organism. One of the indirect products is 5,10-CH2-THF; it is the form, the main precursor of which is folinic acid.

Why folinic acid and not folic acid or methylfolate?
In case of the comparison to the first one, the situation is easy. Folinic acid needs a smaller amount of metabolic processes (smaller losses of the active substances) and it demonstrates higher assimilability in comparison to folic acid; additionally, the intake of the excessive amount of folic acid demonstrates unbeneficial health implications.

Differences when it comes to methylfolate are more subtle. Folinic acid will be a better choice for people oversensitive to products influencing methylation processes (mainly people with diagnosed histapenia or genetic disorders of MTHFR gene), as the form of methylfolate may deepen unbeneficial symptoms of diseases. It is also a better choice for people with diagnosed problems with methylcobalamin metabolism or its large deficiencies (the influence of methylfolate and folic acid on the prevention of intensive hair loss was compared in chemotherapy with methotrexate. The application of this drug results in intensive hair loss. Moreover, the influence on limiting this effect by the application of methylfolate and folinic acid was compared. For the second time it demonstrated a much better effect).

Sole folinic acid in the organism may be responsible for:
Neuroprotective and antidepressant effect – decreases the risk of neurologically related poisonings (mainly by heavy metals, dexamethasone and beta-amyloid). It synergistically influences the substances used in antidepressant therapies (drugs from the group of SSRI and TCA); decreases the time needed for their effective activity. Research also proved direct influence of the high level of folates in the plasma on preventing depression and positive influence on maintaining cognitive functions in Parkinson’s and Alzheimer’s diseases.

Antioxidant effect – demonstrates antioxidant activity on DNA oxidative damage (mainly be decreasing the level of homocysteine; 8-0HdG marker responsible for indicating this type of damages was decreased in the study after the intervention with folates).

Protective effect during pregnancy – in proper supplementation during pregnancy, folic acid is able to decrease the risk of neurological complications related to the damages of neural tube in the fetus to 0. Research also indicates the probability to decrease the risk of other defects of the baby, such as cleft lip or palate as well as hypertension of the mother.

Positively influences the circulatory system – it improves blood flow, especially in case of therapeutic application in certain cardiological diseases (e.g. coronary artery disease). Folate deficiency may also cause anemia (folates take part in the production of red cells).

To sum up, Seeking Health Folinic Acid is a good choice for people who want to supplement vitamin B₉ more effectively than in case of simple folic acid, and who due to health reasons cannot use L-methylfolate. It will work great as an element of constant and interventional supplementation during pregnancy, depression episodes or problems with the circulatory system.