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Life Extension Methylcobalamin is a dietary supplement with a biologically active form of vitamin B12 (methylcobalamin), which has a beneficial effect on the functions of the nervous system and the brain. Moreover, it is crucial in the process of cell growth and replication.
The supplementing components of the lozenges are also: xylitol, natural vanilla flavour, sorbitol, stearic acid, tapioca starch, tapioca maltodextrin and stearates of plant origins.
Why is methylcobalamin the best form of B12?
Some organisms are unable to efficiently convert the form of vitamin B12 that is common in supplements (cyanocobalamin) into the right amount of biologically active methylcobalamin, which, as a methyl donor, is necessary for the normal functioning of nerve cells and exhibits neuroprotective properties.
Vitamin B12 - a common name for a group of cobalamins, that is corrinoids - compounds containing cobalt in their corrin ring - which exhibits the biological activity of vitamins. Its main source for humans are foods of animal origin, as plants do not produce it. It proves that vegans are a group of high risk when it comes to B12 deficiencies.
The deficiency of B12 as a cofactor is a reason for the impaired activity of methionine synthase, which leads to the accumulation of homocysteine and the so-called "folate trap" - the functional folate deficiency, resulting from methylcobalamin deficiency.
Methylcobalamin vs. homocysteine
A particularly important enzyme dependent on B12 is methionine synthase which catalyses the remethylation of homocysteine to methionine in the reaction with methylfolate (5-MTHF). It is so relevant because in that process, the level of homocysteine in the system is reduced, and the substance is an independent risk factor in the development of atherosclerosis, thrombotic disorders, strokes and cardiac arrest.
Conducted studies showed that about 30% of Polish adults have too high a level of homocysteine in the blood, which means they have a condition is called hyperhomocysteinaemia. The most frequent reason for that state of matters are deficiencies of vitamin B12, B6 and methylfolate. Proper supplementation with those vitamins reduces the level of harmful homocysteine, protecting the cardiovascular system from complications.
Pernicious anaemia occurs when, as a result of methylcobalamin deficiency, first the metabolism of folic acid, then erythropoiesis is distorted, which leads to the release of immature red blood cell precursors from the bone marrow to the blood (megaloblastic anaemia). The most common reason for pernicious anaemia is impaired absorption of vitamin B12 from the gastrointestinal tract.
Vitamin B12 performs that function of a regulator in the production of red blood cells and guarantees normal erythropoiesis, that is the process of producing and differentiating erythrocytes from stem cells in the bone marrow. Its deficiency causes anaemia. Proper supplementation restores the normal level of erythrocytes in the blood, necessary for keeping the right aerobic capacity in sportspeople.
Consequences of deficiency
Cobalamin deficiency manifests itself through a complex syndrome whose main symptoms are neurological, haematological and psychiatric disorders. The biochemical ground of the syndrome is impaired methionine metabolism, caused by the lack of the enzyme cofactor (in this case, cobalamin) in methionine synthase. It can be life-threatening when untreated.
The reasons for B12 deficiency can be a vegan diet or impaired absorption caused, among other factors, by using drugs for heartburn - proton pump inhibitors (PPI).
Other functions of B12:
Cobalamin also performs many other (equally important) biological functions: it participates in creating the non-protein component of the enzymes that process nitrogenous bases, directly affecting the synthesis of nucleic acids; it participates in metabolising proteins, fats and carbohydrates, plays an important role in synthesising neurotransmitters and creating neurolemma that protects nerve cells.
To sum up, Life Extension Methylcobalamin is a dietary supplement recommended for people with methylation disorders, a high level of homocysteine, symptoms of anaemia and neurological and psychiatric disorders. Taking methylcobalamin allows an immediate biological action, as well as is an alternative for cyanocobalamin conversion which can be a problem for some people.
Vitamin B12 is good for mental health - it improves mood and increases resistance to stress. Deficiencies of this vitamin are very common - it is estimated that only ten percent of the population has proper levels. Due to the fact that it naturally occurs mainly in animal products, its supplementation is a must for vegetarians and vegans, but considering all the health promoting properties of vitamin B12 it should be taken by everyone. When planning supplementation take into consideration both your dose, as well as its form, because the absorption of vitamin B12 is a complicated process. I recommend vitamin B12 in the form of methylated (i.e., methylcobalamin) Vitamin B12 is difficult to overdose. It dissolves in water and is rapidly cleared from the body. You should know that the absorption of vitamin B12 very improves contained in the popular spice - black pepper, piperine. Vitamin B12 should also be combined with calcium, which improves its absorption. If you take vitamin C, be sure to keep an hour break between Vitamin C and vitamin B12. Vitamin C weakens the absorption of B12.
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|per 1 lozenge||amount||%DV|
|Vitamin B12 (as methylcobalamin)||5 mg||-|
xylitol, sorbitol, maltodextrin, stearic acid, vegetable stearate, natural vanilla flavor, rice starch, modified food starch.
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
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