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Seeking Health Hydrox-Adeno B12 is a source of two perfectly absorbable forms of vitamin B12: hydroxocobalamin and adenosylcobalamin. The preparation is an invaluable support for digestion and metabolic processes and promotes also proper formation of red cells and neuronal somas.
Vitamin B12 (cobalamin) – in terms of chemistry, it is a organic compound with cobalt in the oxidation state of + 3 as the central atom. Hydroxocobalamin and adenosylcobalamin belong to stable, bioavailable forms of the vitamin. Vitamin B12 is a crucial coenzyme of many reactions in the human body, including methylation which is extremely important to proper nutrient absorption.
Cobalamin and methylation
Vitamin B12 is a coenzyme necessary for the whole methylation, a process consisting in the addition of methyl molecule to specific compounds, making them available to the body. Even though this mechanism is very significant to metabolic homeostasis of the body, it can be disturbed quite easily. Factors impairing methylation reactions include stressors such as heavy workouts or mental load. That is why hard-training athletes should take special care of the efficiency of this process, both by means of a diet based on unprocessed products and proper supplementation support. Vitamin B12 is thus a perfect solution.
Cobalamin is a coenzyme of two key methylation reactions: the conversion of homocysteine into methionine and methylmalonyl-CoA into succinyl-CoA. The second reaction is particularly important to body energy balance because it facilitates providing propionate for the metabolism of pyruvate, which is involved in the Krebs cycle – the basic mechanism of energy production in aeorbic metabolism.
The impact on the health of the cardiovascular system
Vitamin B12 is also a very important factor determining the health of the cardiovascular system because it is responsible for two mechanisms necessary for maintaining the efficiency of venous-arterial blood flow. The first one is based on the already mentioned reaction concerning the methylation of homocysteine into methionine. In the case of insufficient vitamin B12 supply, the reaction proceeds less efficiently, leading to elevated blood homocysteine levels. The consequence of hyperhomocysteinaemia is damages to the blood vessel bed which is the primary cause of atherosclerotic plaque formation.
Cobalamin is also a regulator of erythropoiesis, namely differentiation of erythrocytes from a hematopoietic stem cell in the red bone marrow. Vitamin B12 deficiency in diet contributes to abnormal proliferation of red blood cells at the stage of conversion of reticulocytes. It can be detected in blood cell count by the presence of megalocytes (enlarged red blood cells). Impaired functions of abnormally large erythrocytes contribute to the so-called megaloblastic anaemia.
The health of the cardiovascular system
Vitamin B12 plays a significant role in proper neurotransmission. Cobalamin is one of the regulators of myelination that is the formation of myelin sheaths along the neuronal cell bodies. Not only are they shown to protect nerve cells but they also determine the normal speed of transmission of nerve impulses. Myelination disorders may contribute to decreasing the efficiency of cognitive functions, coordination and in extreme cases to structural damages to nerve fibres.
To sum up, Hydrox-Adeno B12 is a perfect metabolic support which should be considered by all individuals exposed to methylation disorders, mainly because of their lifestyle. Frequent workouts and also stress in everyday life will disrupt this process which is extremely important to your metabolic health. Because of that, your supplementation regimen should comprise an additional support in the form of vitamin B12 in the most bioavailable forms.
When supplementing vitamin B12, it is suggested to monitor regularly blood homocysteine levels. When hyperhomocysteinaemia perists despite of vitamin B12 supplementation, it suggested to test for MTHFR gene polymorphism. In the event of mutation, supplementing with other forms of cobalamin than the methylated one is totally pointless.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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What is hydroxocobalamin?
Hydroxocobalamin is one of four available forms of vitamin B12. Its advantage over cyanocobalamin consists in the ease of conversion to biologically active forms. It is sometimes used as an antidote in cyanide poisonings, because of high affinity to its ions. This form of vitamin B12 may be an interesting alternative for people, who for various reasons cannot use methyl group donors and want a better-quality supplement than the popular cyanocobalamin.
Vitamin B12 is incredibly important for maintaining proper energy metabolism and high condition of the nervous system. Because of the influence on neurotransmitter synthesis, it contributes to the improvement of mood and psychological functions. It also takes part in DNA synthesis and creatine production by the possibility of increasing the concentration of SAMe. It also helps to maintain homocysteine level in lower values, as it supports its remethylation to methionine. It also plays an important role in blood-forming processes and regeneration of myelin sheaths in neurons.
Hydroxocobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
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