Data is transferred and analyzed by external vendors. The whole should not last more than 30 seconds.
Order: | 61.00 $ | 121.00 $ | 182.00 $ | 243.00 $ | 304.00 $ |
---|
Shipping: | -3.00 $ | -6.00 $ | -9.00 $ | -12.00 $ | -15.00 $ |
---|
Order: | 61.00 $ | 121.00 $ | 182.00 $ | 243.00 $ | 304.00 $ |
---|
Shipping: | -3.00 $ | -6.00 $ | -9.00 $ | -12.00 $ | -15.00 $ |
---|
This is a simple and extremely useful tool (a shipping cost progressive bar) that allows you to control the distance that separates from the next shipping discount threshold.
This is a simple and extremely useful tool (a shipping cost progressive bar) that allows you to control the distance that separates from free delivery.
Confirm or change your preferred country of delivery, language or currency. If you do this when logged in, your preferences will be remembered on your MZAccount. You can change them at any time by clicking the arrow at the top of the page.
Your location affects the final order price. It may vary depending on the amount of VAT rate applicable at your current location.
default stock for current location
alternative stock
unavaiable stock
From 3 units only: 17.14 $ / Units. -2%
Life Extension Optimized Folate is a highest quality dietary supplement with optimised folate, i.e. a bioactive form of folic acid 5-MTHF (5methyltetrahydrofolate) in the amount of 5000 mcg in one vegetarian tablet.
Bioactive folate ensures maximum support both for the health of the cardiovascular system and for cognitive functions. It is recommended to supplement 5-MTHF together with methylcobalamin (B12) and vitamin B6.
Folate (pteroylglutamate) - also called folic acid, vitamin B9 or B11, synthesised by intestinal bacteria; its bioactive form is tetrahydrofolate (THF) which performs the function of a coenzyme in the reactions of the transfer of active monocarbon groups (methyl, formyl, formimino, methylene, methenyl groups).
Why is "ordinary" folic acid not the right one?
Commonly used folic acid, a component of many dietary supplement, has very limited effect on many people, as not every organism is able of converting the compound into the biologically active form 5-MTHF, which is caused by a genetic deficiency of enzymes that enable the conversion.
That situation has very bad consequences for health and may lead to, among other things, a pathologically high level of homocysteine and cognitive function disorders. Moreover, a link has been found between folic acid supplementation and increased incidence of rectal, breast and prostate cancer as well as autism in children.
Homocysteine as a risk factor
Homocysteine is a sulphur-containing amino acid which occurs in the human organism as a result of demethylation of the amino acid called methionine. It is currently thought to be an independent risk factor in the development of atherosclerosis, the coronary heart disease, heart attacks and thrombotic disorders.
The above-described changes are caused by impeded 5-MTHF synthesis by methylenetetrahydrofolate reductase which leads to functional folate deficiency and, in turn, to impeded remethylation of homocysteine to methionine.
5-MTHF (5methyltetrahydrofolate) - also called levomefolic acid; it is a biologically active form of folic acid and the main source of tetrahydrofolates for tissues. It plays a unique role in remethylation of homocysteine to methionine. The reaction is catalysed by methionine synthase, which is an enzyme dependent on methylcobalamin (vitamin B12). The consequence of the reaction mentioned above is the production of methionine, which reduces the level of homocysteine in the system, preventing the development of circulatory system diseases.
Biological functions of folates
Folate is one of haematopoietic factors which determine the normal process of erythropoiesis, i.e. the process of erythrocyte multiplication and differentiation (red blood cells) from stem cells in the bone marrow of flat bones and long bone epiphyses. Moreover, it has an important function in DNA synthesis, cysteine metabolism, synthesis of essential neurotransmitters (dopamine, norepinephrine and serotonin) and endorphins.
Deficiency consequences
Folate deficiencies lead to megaloblastic anaemia, which occurs as a result of impeded DNA synthesis that brings about blood cell maturation disorders. In addition, some disorders of the central nervous system may occur, which also needs the vitamin for the normal functioning - it has been demonstrated that about 30% of patients with mental disorders have a low concentration of folate in the blood.
Recommended for pregnant women
Folate supplementation is very important for pregnant women, as it is responsible for the normal development of the nervous system in a growing foetus. Folate supplementation before conception in the amount of 400 mcg per day can significantly reduce the risk of spina bifida and other defects of the foetus' neural tube.
To sum up, Life Extension Optimized Folate is an obligatory product for people with methylation disorders, an increased level of homocysteine and for mothers-to-be. For best results, it should go together with methylcobalamin and vitamin B6 supplementation.
We recommend the use of folate in the planning phase of pregnancy. It minimizes risk of neural tube defects in the fetus. Natural sources of folate are dark green vegetables, whole-grain, legumes. But these compounds are very unstable and easily degraded by the technological processes.
200 characters left for the review to be rated.
per 1 tablet | amount | %DV |
---|---|---|
Folate [as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt] | 5000 mcg | 1250% |
microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.
Source of easily assimilable chromium deriving from the fermentation process of Saccharomyces cerevisiae yeast.
BuyAcai and acerola fruit extracts, Vitamin C and chromium. Natural support of antioxidant defense.
BuyColostrum obtained from bovine milk of the highest quality. High content of immunologically active compounds.
BuyA blend of natural compounds strengthening the immune system. Contains cordyceps and colostrum.
Buy
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Acerola – the best natural source of vitamin C
Acerola is a wonderful plant, which originates from the Canary Islands. It is worth learning more about its properties, as it has a very wide application effect....
Synergy of supplements, part 3 – Caffeine and theanine
Asking a group of people about the most pleasant part of the morning, certainly the answer will be… coffee. And no wonder, because the caffeine contained in...
Stimulants Battle Royal! Main competitor – caffeine!
In this article, we will discuss five substances most often compared to caffeine. We hope that thanks to this our readers will get full knowledge about the...
Coffee and caffeine and theirs benefits for an active person
Coffee is a widely used drink, due to the stimulation of the nervous system and an aroma that is extremely attractive for some people. Many people can not imagine...
Berberine relieves symptoms of acne vulgaris
Barberry (B. vulgaris) is a plant widely used in herbal medicine for millennia. The main chemical compound that determines the effect of barberry is berberine...
Caffeine versus other stimulants!
In this article, we will discuss five substances most often compared to caffeine. We hope that thanks to this our readers will get full knowledge about the...