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MegaFolinic 800mcg MegaFolinic 800mcg

Source Naturals MegaFolinic™ is a high-quality supplement that constitutes a source of fantastically bioavailable folinic acid. It has a beneficial effect on the functioning of the organism, especially in terms of the nervous system and normal DNA metabolism.

Folinic acid (5-formyltetrahydrofolate) – a naturally occurring formyl form of tetrahydrofolic acid. It can be produced from folic acid; however, because of frequent problems with the natural conversion of folic acid observed in society, folinic acid is believed to be much more effective. What is more, people who have problems with transforming the basic form of folic acid, 5-formyltetrahydrofolate can be a safer option.

Metabolically active without the need of conversion
The high bioavailability of folinic acid stems from the fact that it can permeate into cells directly and exhibits metabolic activity without the need to convert it further. It can be transformed into other forms of folate but it can also enter metabolic pathways as a coenzyme of transferases, which are responsible for the transport of carbon derivatives during the synthesis of purine and pyrimidine nucleotydes.

Effect on nucleic acid biosynthesis
The presence of 5-formyltetrahydrofolate during nucleotide biosynthesis is responsible for one of the main areas of activity of the supplement, that is caring for the right metabolism of nucleic acids. That way, folinic acid affects the life cycle of the entire cell, determining its normal development and differentiation. Moreover, it is also said that folates (including 5-formyltetrahydrofolate and L-5-formyltetrahydrofolate) have a protective effect on the DNA. They can protect nucleic acids from the harmful activity of free radicals, which cause excessive oxidative stress.

Support for immune system function
Folates are also believed to be a natural way to support immune system function. It has been demonstrated that they are able to stimulate the activity of NK cells. They are responsible for processes typical of the initial stage of the immune response. That way, folinic acid supplementation can have a beneficial effect on the efficacy of the immune system in the organism.

Neuroprotective properties
Unlike folic acid, whose supplementation in people suffering from disorders of its conversion can turn out neurotoxic, folates are believed to be compounds with neuroprotective properties. They have a neutralising effect on a number of substances that are toxic for nerve cells. What is more, because of their participation in S-adenosyl methionine synthesis, folate deficiencies are thought to be one of the potential reasons of developing depression.

Protection of the cardiovascular system
Another factor connected with S-adenosyl methionine transformations is the ability of folate coenzymes to reduce homocysteine levels, as they participate in its conversion to methionine. It is essential to the health of the circulatory system, as homocysteine is a significant factor in the development of cardiovascular diseases. Folinic acid supplementation can prevent its elevated levels by promoting its natural metabolic pathway in the organism.

The presence of folates on the synthesis pathway of morphotic elements in blood is also relevant for the functioning of the cardiovascular system. Apart from that, folate coenzymes are involved in the synthesis of haem, which ensures the normal functioning of erythrocytes.

Preventive activity in folic acid antagonist administration
Folinic acid is also important as an aid in therapies with folic acid antagonists. The group includes, for example, statins, which are often prescribed in order to regulate the lipid profile, or some oral contraceptives. In that case, 5-formyltetrahydrofolate has an antitoxic effect. Administering for that purpose should always be supervised by a medical practitioner.

To sum up, Source Naturals MegaFolinic™ is a supplement constituting a safer and more bioavailable alternative for folic acid. It can be used safely by people who have problems with converting folic acid. It is directly involved in metabolic processes on a cellular level, because of which it has a wide range of health-promoting effects on the organism.

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Since 2005
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MegaFolinic 800mcg MegaFolinic 800mcg 60 tab.
Source Naturals
13.48 $

MegaFolinic 800mcg 60 tab.

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01709231594 (mon.-fri 900-1700)

- Delivery even day after tomorrow

- Foreign shippment from 5.61 $ Every 82.56 $ reduces shipping costs by 2.75 $

You have got questions about the product

consultations@mz-store.com

01709231594 (mon.-fri 900-1700)

Description
  • Top-quality source of biologically active folinic acid
  • Suitable for people with folic acid conversion disorders
  • Supports normal nucleic acid metabolism
  • Protects DNA from activity of free radicals
  • Promotes efficacy of immune response
  • Protects cardiovascular system
  • Able to reduce homocysteine levels
  • Able to prevent depression
  • Exerts neuroprotective effect

Source Naturals MegaFolinic™ is a high-quality supplement that constitutes a source of fantastically bioavailable folinic acid. It has a beneficial effect on the functioning of the organism, especially in terms of the nervous system and normal DNA metabolism.

Folinic acid (5-formyltetrahydrofolate) – a naturally occurring formyl form of tetrahydrofolic acid. It can be produced from folic acid; however, because of frequent problems with the natural conversion of folic acid observed in society, folinic acid is believed to be much more effective. What is more, people who have problems with transforming the basic form of folic acid, 5-formyltetrahydrofolate can be a safer option.

Metabolically active without the need of conversion
The high bioavailability of folinic acid stems from the fact that it can permeate into cells directly and exhibits metabolic activity without the need to convert it further. It can be transformed into other forms of folate but it can also enter metabolic pathways as a coenzyme of transferases, which are responsible for the transport of carbon derivatives during the synthesis of purine and pyrimidine nucleotydes.

Effect on nucleic acid biosynthesis
The presence of 5-formyltetrahydrofolate during nucleotide biosynthesis is responsible for one of the main areas of activity of the supplement, that is caring for the right metabolism of nucleic acids. That way, folinic acid affects the life cycle of the entire cell, determining its normal development and differentiation. Moreover, it is also said that folates (including 5-formyltetrahydrofolate and L-5-formyltetrahydrofolate) have a protective effect on the DNA. They can protect nucleic acids from the harmful activity of free radicals, which cause excessive oxidative stress.

Support for immune system function
Folates are also believed to be a natural way to support immune system function. It has been demonstrated that they are able to stimulate the activity of NK cells. They are responsible for processes typical of the initial stage of the immune response. That way, folinic acid supplementation can have a beneficial effect on the efficacy of the immune system in the organism.

Neuroprotective properties
Unlike folic acid, whose supplementation in people suffering from disorders of its conversion can turn out neurotoxic, folates are believed to be compounds with neuroprotective properties. They have a neutralising effect on a number of substances that are toxic for nerve cells. What is more, because of their participation in S-adenosyl methionine synthesis, folate deficiencies are thought to be one of the potential reasons of developing depression.

Protection of the cardiovascular system
Another factor connected with S-adenosyl methionine transformations is the ability of folate coenzymes to reduce homocysteine levels, as they participate in its conversion to methionine. It is essential to the health of the circulatory system, as homocysteine is a significant factor in the development of cardiovascular diseases. Folinic acid supplementation can prevent its elevated levels by promoting its natural metabolic pathway in the organism.

The presence of folates on the synthesis pathway of morphotic elements in blood is also relevant for the functioning of the cardiovascular system. Apart from that, folate coenzymes are involved in the synthesis of haem, which ensures the normal functioning of erythrocytes.

Preventive activity in folic acid antagonist administration
Folinic acid is also important as an aid in therapies with folic acid antagonists. The group includes, for example, statins, which are often prescribed in order to regulate the lipid profile, or some oral contraceptives. In that case, 5-formyltetrahydrofolate has an antitoxic effect. Administering for that purpose should always be supervised by a medical practitioner.

To sum up, Source Naturals MegaFolinic™ is a supplement constituting a safer and more bioavailable alternative for folic acid. It can be used safely by people who have problems with converting folic acid. It is directly involved in metabolic processes on a cellular level, because of which it has a wide range of health-promoting effects on the organism.

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Composition

Composition

Container size: 60 tabletsServing size: 1 tabletServings per container: 60
per 1 tabletamount%DV
Folate (as calcium folinate [folinic acid])800 mcg200%

Other ingrednients

microcrystalline cellulose, stearic acid, and magnesium stearate.

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Calcium folinate

Information

Calcium folinate - a metabolite of tetrahydrofolic acid constituting a perfect form of its supplementation. Tetrahydrofolic acid is a biologically active form of folic acid, especially recommended to people dealing with methylation disorders. Folic acid in the active form is at the same time a promotor of this process, but it requires efficient action for its activation, therefore in case of methylation disorders, folates are the only effective form of supplementation of this compound.

Folic acid is mainly associated with pregnancy. In its active form, it is responsible for the regulation of the development of the neural tube of the fetus, which constitutes a key factor, conditioning its proper development. Providing folates is currently indicated as the most effective form of healthy pregnancy prophylaxis.

Another important aspect of the functionality of tetrahydrofolic acid in the organism is its role in the process of methylation. It positively influences the efficiency of transformations of homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. The efficiency of this process is also conducive to maintaining the high concentration of S-adenosyl methionine in the organism. This compound demonstrates special influence on maintaining optimal mental functions and healthy liver.

 

 

Folinic acid

Information

Folinic acid - 5-formyltetrahydrofolate, a biologically active form of folic acid. Its supplementation is recommended especially to people with methylation dysfunctions, as it is essential for the transformation of folic acid to the active folate. Taking into consideration the increasing tendency to disorders in this respect, folates are more and more often recommended as the basic, preferred forms of supplementation with folic acid.

Supplementation with these folates is especially recommended to women who are planning pregnancy or are pregnant. Folic acid in the biologically active form is responsible for regulating the formation of neural tube in the fetus and is conducive to its proper development.

In adults, folates are conducive to optimal methylation processes. It takes part in transforming homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. In this way, it positively influences psyche, as the effectiveness of this process is conducive to the production of S-adenosyl methionine with considerable influence on maintaining proper emotional states.

Some sources also indicate the protective influence of folates on the development of cancers. This information, however, is not fully unambiguous. The present state of knowledge suggests that since the optimal supply of folates really decreases the risk of cancer development, its supplementation in excessively high doses may demonstrate the reverse effect.

 

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