Dietary supplements Supplementation

Ibutamoren (MK-677): 9 health benefits

Ibutamoren Mesylate is a substance that arouses considerable controversy. In various discussion forums, debates about it go on forever. Probably the theory about this supplement is more than real scientific research. However, previous studies confirm a number of benefits associated with ibutamorenem, related to its ability to increase levels of growth hormone and IGF-1 levels. Read on to find out what are the
benefits of supplementing ibutamoren, or how ibutamoren can help you build the figure you want and... if it actually heals a hangover!

Basic information
Ibutamoren is often discussed on online forums because of its muscle building properties. It is available without a prescription and used by people who want to increase the level of growth hormone. However, clinical studies of this substance are relatively poor. In the following text we present information on ibutamoren, which are confirmed by scientific research. Ibutamoren (also known as ibutamoren mesylate or MK-677), supports the secretion of growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) [1]. This is a fact that can not be discussed.

    Ibutamoren increases the level of growth hormone by mimicking the action of the ghrelin hormone and binding to one of the ghrelin receptors (GHSRs) in the brain. Activated GHSR stimulates the release of growth hormone. GHSR is found in areas of the brain that control appetite, pleasure, mood, and biological rhythms, memory and cognitive functions [2]. Therefore, we can expect that ibutamoren can also affect all these functions. However, so far clinical studies only describe the effect of ibutamoren on appetite - and as expected, as in the case of ghrelin, it has a stimulating effect on our appetite.


    The great advantage of ibutamoren is that it increases the level of growth hormone with a small increase in other hormones, e.g cortisol [3] or without any additional interference in our hormonal balance. Cortisol badly affects the immune system, slows down the wound healing process, impairs learning and memory. In most cases, in our lives, except for moments in which we fight, the elevated level of this hormone works against us.

    Benefits of ibutamoren supplementation:

    1) Ibutamoren helps in building muscles
    Ibutamoren is often used as an anabolic substance to increase lean body mass, i.e. to create larger, fuller muscles. It is active in oral form and can be taken once a day. These are all benefits compared to other growth hormone stimulators. As already mentioned, ibutamoren increases levels of growth hormone and IGF-1 [4]. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength and reduce adipose tissue [5]. In 24 obese men, the two-month treatment (DB-RCT) with ibutamoren increased the fat-free mass and temporarily increased the basic metabolism (BMR) [6].

    2) Ibutamoren prevents loss of muscle mass
    In a study (DB-RCT) of eight healthy volunteers, ibutamoren reversed the diet-induced protein loss [6], which could have caused muscle atrophy. In 123 elderly patients with a hip fracture, ibutamoren improved walking speed, muscle strength and decreased falls (RCT) [8].


    3) Ibutamoren increases bone density
    Growth hormone (GH) increases bones mineral absorption and eventually bones density [9]. However, due to the increased turnover in patients treated with growth hormone, the bone density may initially decrease before the increase [10]. Basically, it takes time (> 1 year) to see a statistically significant increase in bone density. In 24 healthy, obese male volunteers, ibutamoren increased bone density (DB-RCT). In 187 older adults (aged 65 and more), ibutamoren increased bone formation, measured by osteocalcin, and a bone density marker in many studies (3 DB-RCT) [11]. In one study (DB-RCT) with 292 postmenopausal women, ibutamoren increased bone mineral density, which helps to increase bone strength and prevent osteoporosis.


    4) Ibutamoren lets you sleep more efficiently
    The study (DB-PCT) showed that both in younger and older people, ibutamoren improved the quality of sleep and increased REM sleep time phase (rapid eye movement) [12].
    In addition to scientific research, there have been many reports about subjective improvement of sleep quality in various internet forums. Lack of sleep translates into lowering the quality of our lives. It reflects both on our functioning at work and in the training room. That is why it is so important to provide yourself with the best possible, most restorative sleep.

    5) Ibutamoren counteracts the aging process and extends life
    The secretion of growth hormone (GH) and the production of muscle mass decreases with age [13]. In a study of 65 elderly men and women (DB-RCT), daily supplementation with ibutamirtine increased the levels of GH and IGF-1 without serious side effects [14]. It is well known that IGF-1 has a beneficial effect on longevity [15]. In another study involving 24 obese men (DB-RCT), ibutamoren "rejuvenated" the growth hormone profile [16].

    6) Ibutamoren can have a nootropic effect
    Some use ibutamoren as nootropic agent because it acts on the ghrelin receptor. Two indirect mechanisms by which ibutamoren can improve brain function:
    - ibutamoren increases IGF-1, which is known for improving memory and learning processes [17],
    - ibutamoren also increases REM sleep time and sleep quality [18]. We also know that sleep is essential for optimizing cognitive functions [19].
    In one study, ibutamoren was ineffective in slowing the progression of Alzheimer's disease in humans [20].

    7) Ibutamoren is effective in the treatment of growth hormone deficiency
    Ibutamoren may increase levels of growth hormone, IGF-1 and IGFBP-3 in children with growth hormone deficiency. In addition, these effects are achieved without changing the concentration of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin. In severely ill men with GH deficiency, ibutamoren increase IGF-1 and growth hormone, without significant changes in cortisol, PRL and thyroid hormones. However, an increased amount of insulin and glucose (DB-RCT) has been reported [21].8) Ibutamoren can help you heal wounds and regenerate tissues
    Growth hormone supports tissue regeneration and wound healing [22], so ibutamoren can be effective in that case. However, there is a lack of proper studies.

    9) Ibutamoren can help to heal a hangover!
    We lack scientific evidence, but more and more often one can read about the salutary influence of ibutamoren on the post-party morning syndrome!

    References:

    1. https://www.ncbi.nlm.nih.gov/pubmed/11452249
    2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757071/
    3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC384806/
    4. https://www.ncbi.nlm.nih.gov/pubmed/8768828
    5. https://www.ncbi.nlm.nih.gov/pubmed/8940347
    6. https://www.ncbi.nlm.nih.gov/pubmed/8784075
    7. https://www.ncbi.nlm.nih.gov/pubmed/10352397
    8. http://jap.physiology.org/content/84/5/1716.long
    9. https://www.ncbi.nlm.nih.gov/pubmed/9467542
    10. https://www.ncbi.nlm.nih.gov/pubmed/9467542
    11. https://www.ncbi.nlm.nih.gov/pubmed/21067829
    12.https://www.ncbi.nlm.nih.gov/pubmed/10404019
    13. https://www.ncbi.nlm.nih.gov/pubmed/11238495
    14. https://www.ncbi.nlm.nih.gov/pubmed/9349662
    15. https://www.ncbi.nlm.nih.gov/pubmed/14563498/
    16. https://www.ncbi.nlm.nih.gov/pubmed/19913048?dopt=Abstract
    17. https://www.ncbi.nlm.nih.gov/pubmed/9467542
    18. https://www.ncbi.nlm.nih.gov/pubmed/10022403?dopt=Abstract&holding=npg
    19. https://www.ncbi.nlm.nih.gov/pubmed/14598295/
    20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980112/
    21. https://www.ncbi.nlm.nih.gov/pubmed/11452249
    22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501119/

     

    About author

    David

    David

    I am a graduate of the Physical Education course of Western University of Health Sciences. A lot of personal experience with dietetics and activities perfectly compliments my high-school knowledge.

    I am the coach of the second class of canoeing. Instructor of swimming, gymnastics, athletics, and pilates. For 16 years, I have been practising canoeing - I have won many medals in international competitions.

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