Ostarine – SARM #1

Jack Howard

SARMs is a group of substances, which gains still more attention. Some say, that SARMs are steroids in capsules, others says that they are revolutionary supplements, which is a good compromise between rarely working supplements, and steroids which are hard to get and apply in daily supplemention. Also, their impact on health is very complex topic, which without knowledge about biochemistry and pharmacology can be just highly confusing and unclear. In results, use of steroids oftenly ends disastrously. Are SARMs good alternative to steroids? Are SARMs dangerous? And where to buy tested and best SARMs? We welcome you to series of articles regarding SARMs, and at the first shot, the most popular SARM right now - Ostarine!

What is ostarine?

    Ostarine is SARM - selective androgen receptor modulator. In short, it shows actions similar to androgens (because our organism recognizes SARMs as androgens!). Do you know any androgens? Well, you just have to - testosterone or DHT are the most important androgens.

    What do androgens do?
    Well, they are responsible for male characteristics - hair all over the body, low voice, wide shoulders and the most important muscles development. That is why, SARMs are so oftenly recommended in time of building muscle mass.

    To be exact - Ostarine is ((2 S)-3-(4-cyanophenoxy)- N -[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide), also known as MK-2866, GTX 024 and enobosarm. In short it is a substance being helpful during osteoporosis and chronic diseases destroying muscles. Ostarine is also very beneficial in the world of endurance sports such as cycling and running, resulting in a huge improvement in muscle strength.

    SARM MK-2866 Ostarine
    SARM MK-2866 Ostarine from Hades Hegemony is the most popular and widely used Ostarine at the market, basing on reviews of our customers

    How Ostarine works? What does Ostarine do?

    Can Ostarine cause gyno / gynecomastia?

    MK-2866 binds to the ARs demonstrating an anabolic effect. Ostarine does not convert to estrogen and DHT, because it has not a steroid structure. Thanks to that, enzymes that convert to the aforementioned hormones on a reductase and aromatase, are unable to join. Additionally, in contrast to testosterone and other anabolic steroids, SARM not induce effects on the growth of prostate cancer and other genital organs.

    Ostarine and joints

    Nevertheless, we often hear about the increased level of estrogen during ostarine supplementation. This is due to the stimulation of the androgen receptors. In the organism, in natural conditions, there is also the phenomenon of aromatase, stimulating receptors results in just such changes. Estrogen at the appropriate level is beneficial for our joints. This happens due to anti-inflammatory action, and collagen synthesis mechanism stimulation, whose product is a component of our tendons, skin, and articular cartilages.

    Action confirmed in the scientific study on efficacy of MK-2866 administered to people over the age of 60, and women after menopause. It is worth noting that these waere people were not exercising in the gym for sure, so their incentives for growth were not too big!

    wykres-ostarynaSource: http://www.ncbi.nlm.nih.gov/pubmed/22031847

    Ostarine for cutting / Ostarine for fat loss. Can Ostarine be used to help in losing weight?

    Ostarine can be successfully used for cutting and losing weight support. Thanks to higher androgens level, men have lower body fat level, than women, and fat metabolism is significantly more intensive. Also, Ostarine can increase epinephrine/ norepinephrine levels. That means higher energy level, and boost of metabolism. And in result - faster lose of weight!

    Ostarine for bulking

    SARMs are called steroids in capsules, as we stated it before. It is kind of true - they act similiarly to higher testosterone level in our organism (which is the obvious result of using steroids). Certain is also that the higher androgens level in our organism, the more muscle mass we can build. Do you see relation already? When we take Ostarine, our organism act like there is more testosterone level, and in result we can build additional muscle mass, and it all thanks to use of Ostarine!

    Can Ostarine be used by women? Ostarine for women?

    Technically women can use ostarine, to boost muscle mass development. Nontheless, our dear ladies have to be more cautious, because overactivity of androgens receptor is not natural for their bodies, and can cause problems with hormonal balance in result. So, if you are used to take steroid-like substances, and you are completly sure about what you are doing, and taking, then Ostarine can be additional help in achieving higher dry body mass level. Otherwise, we advise to use safer options, like herbal testosterone boosters.

    How to dose Ostarine? How much Ostarine to take?

    Ostarine has a half-life of approximately 24 hours, so we take it orally once a day – thanks to that it offers a very convenient form of supplementation.

    15-20 mg is the basis to achieve gains in lean body mass.

    20-30 mg, if we want to achieve a spectacular performance of muscle mass and strength.

    10 mg, if we want to improve the condition of the joints, and the overall efficiency of production of collagen.

    Individual proportions of a dosage we use in more complex cycles, for example: prohormones and SARM or SARM and PCT. You should consult doses with specialists.

    How and when to take Ostarine?

    There is no specific time of taking Ostarine. More important is to take it continually, to not allow sudden and drastic changes in androgen to estrogen balance. But if you want to maximixe benefits from Ostarine, try to take it at least 30 minutes before workout.

    As other substances, with are not soluable in fat, it is worth to take Ostarine on empty stomach.

    Do I have to take PCT after Ostarine Cycle? Ostarine without PCT

    There is not a clear answer for that question. It is a fact, that Ostarine acts like testosterone mimetic, because of its affinity to androgen receptors. So, concern of blocking natural testosterone production by HPTA axis is natural thing. In the same time, there is no clinical studies regarding comprasion of HPTA affection by androgen esters and Ostarine, so every information about Ostarine, PCT and HPTA interactions are just suppositions based on other similar substances.

    So, PCT usage after Ostarine cycle is rather an option, if you used low doses of it. For example, if you used 10-20mg Ostarine daily, for month, it shouldn't be that bad. Why we say that? Androgen esters are used in much higher doses, and we cannot comprase affinity to HPTA axis 1:1 - Ostarine affinity to androgen receptors and HPTA axis has to be lesser.  Furthermore, there shouldn't be any negative interactions between Ostarine and testosterone - at least that is what we know, basing on knowledge about testosterone and other androgen modulators.

    Nontheless, the most sure way to consider PCT is to make blood tests - testosterone, and estrogen levels should be taken in account mostly. If they are out of standards after the last dose of Ostarine is metabolised by your body, you should immediately start PCT.

    Formulations with Ostarine, and Ostarine comprasion to other SARMs

    Ostarine vs LGD. Ostarine and LGD? Ostarine or LGD?

    Ligandrol or LGD-4033 (4 - ((R) -2 - ((R) -2,2,2-trifluoro-1-hydroxyethyl) pyrrolidin-1-yl) -2-trifluoroMethyl) benzonitrile) is mostly used when you want to gain more strength. Just as Ostarine, LGD is SARM. Probably, those two substances have affinity to different types of androgen receptors. In clinical studies, Ligandrol showed high effectivness in increasing muscle mass, without any specific side effects.

    Analyzing above, Ligandrol is probably safer option than Ostarine. If it is your first SARM cycle, and you want to be sure, that nothing will go wrong, give Ligandrol a chance. If you are professional, and you know your body perfectly, then move on to Ostarine cycle.

    Suggested Ligandrol to buy - Hades Hegemony LGD-4033

    Ostarine vs Cardarine. Ostarine and Cardarine? Ostarine or Cardarine?

    Cardarine or GW-501516 ({4 - [({4-methyl-2- [4- (trifluoromethyl) phenyl] -1,3-thiazol-5-yl} methyl) sulfanyl] -2-methylphenoxy} acetic acid) isn't actually a SARM! Confused? Cardarine is recognized as SARMs by accident, because it entered the market market in time when SARMs were new also, and have similar type of marking with it.

    Actually, Ostarine and Cardarine is probably the combination with Ostarine if you want to improve endurance, and lose weight. Why? Because Ostarine as well as Cardarine works synergistic on that matter - Ostarine affects androgen receptors, improving our hormonal balance, and Cardarine acts like an fat-burner, having affinity to PPAR receptors, improving insulin sensitivity, increasing rate of glycogen and free fatty acids metabolism. So, the best choice is to combine Ostarine and Cardarine, rather than choosing just one of those two!

    Suggested Cardarine to buy -  Hades Hegemony SARM GW-501516

    Ostarine vs RAD-140. Ostarine and RAD-140? Ostarine or RAD-140?

    RAD-140 (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile) is one of the newest SARMs, with probably the highest androgenic affinity in this group of substances.

    It shows very similar actions to Ostarine, just with higher intensity. So if you would like to choose from Ostarine and RAD-140 - if you want something stronger, choose RAD-140. So, where is the catch? It's really hard right now to buy RAD-140. Due to still new regulations regarding SARMs, the market suffers a lack of Radarine right now. But, you can still buy RAD-140 at MZ Store!

    Suggested RAD-140 to buy - Hades Hegemony RAD-140

    Ostarine vs Andarine. Ostarine and Andarine? Ostarine or Andarine?

    Andarine, S4 (Acetamidoxolutamide) is very similar to RAD-140 - it is SARM with very high bioavailability. But its intensivity in affinity compared to RAD-140 is significantly lower.

    So, in short way Andarine is "weaker RAD-140" - but due to that it can be used by more people! For example, it shows effectivness in lowering prostate weight, which suggests its usage in cancer treatment.

    Suggested Andarine to buy - Brawn Nurition Andarine S4

    Ostarine vs Ibutamoren. Ostarine and Ibutamoren? Ostarine or Ibutamoren?

    Ibutamoren or MK-677 (R) -1 '- (2-methylalanyl-O-benzyl-D-seryl) -1- (methylsulfonyl) -1,2-dihydrospiro [indole-3, 4'-piperidine]) is next to Cardarine victim to SARM madness - Ibutamoren isn't a SARM! It affects Growth Hormone Receptors (GHR-S), and to be it's a mimetic of ghrelin hormone.

    The best SARM stack, containing combination of Ostarine, Ligandrol and Ibutamoren

    Ibutamoren can improve quality of sleep, lower cortisol level, and increase level of growth hormone (GH) and insulin growth factor (IGF-1). And that makes Ibutamoren a great addition to every kind of SARM! It is always helpful, and doesn't interact with androgen hormones.

    Suggested Ibutamoren to buy - Hades Hegemony SARM MK-677 Ibutamoren

    But what if I want the best SARM stack containing Ostarine?

    Then we suggest checking SARM Stack from Hades Hegemony - it contains the best combination of Ostarine, Ligandrol and Ibutamoren! It's perfect support for professionals, which want to increase muscle mass, improve strength and lose some weight at the same time! The best time to use SARM stack is at the recomposition period - a time of training, when you optimize muscle growth and fat burn at the same time. We definitely suggest checking it, if you want something new to try!


    1. Ostarine has an anabolic effect just at a dose of 3 mg

    2. Compared to steroids it does not convert to estrogen

    3. It does not block the HPTA – we do not need PCT

    4. It increases the synthesis of collagen – the regeneration of the skin and joints

    5. The half-life and oral form makes it easy to use

    Read more

    SARM - first composition tests!

    SARM - introduction

    Caffeine first, now SARMs - what's next?

    Ibutamoren (MK677) - 9 health benefits

    Epistane - compedium

    Tags: mass, ostarine, ostarine and testosterone, ostarine for joints, ostarine for losing weight, ostarine for muscle mass, ostarine hpta, ostarine steroid, sarm


    1. Avatar
      Jon Anthony

      After RAD140, Ostarine is an another one SARM that is very good for muscles without compromising health quality. Thanks for this post.

    2. Avatar

      Through an 8 week research study I where the subject was orally investing 25mg of Mk-2866 per day for 8 weeks. There was noticeable test suppression starting in week for and continuing until week 8. Blood tests revealed a 400 point drop in free testosterone but not quite complete shutdown. Some PCT is necessary. Full PCT should always be on hand regardless of whether you think you need it or not.

      • David


        That’s absolutely right, yet the results regarding Ostarine shutdown’ish properties are ambiguous. But you are completely right that it’s better to be safe than sorry and have some PCT after the cycle.

        The best option would be to do some blood tests and decide PCT type and dosage basing on results from those.

        Still, no shutdown in 25mg, if the effective dosage is slightly lower is pretty remarkable. We have to be aware that a drop of testosterone doesn’t have to have a linear correlation with the MK-2866 dosage.

        Anyway – good point, thanks for sharing it!

        • Avatar
          Sukhchain Mehra

          Which test need after pct explains pleased

          • David

            Specifically hormones (LH, FSH), Testosterone, SHBG, Estrogen, Prolactin, Cortisol.

            It would be also recommended to do Liver and kidneys function check, to be sure that they work properly after the cycle.

    3. Avatar

      I am a woman, and looking to cut. I am sceptical about taken more than 10gr/day of Osta or staking it.
      What would be the best way to take it, 4 weeks or 8 weeks, to see results?


      • David

        Hi Bianca!

        First we have to ask, what is your main goal of Ostarine supplementation?

      • Avatar
        Liz Cannon

        Yes, I am a woman and looking to do the same –LOSE POUNDS! . I’ve read all the info and dosages, etc, but 1 week in with Cardarine and no results. Also still tired. I want to stack Cardarine with Osterine, and know for women should do about half of what a man would do. BUT….. my question is what all do I need to be doing to make this work, and work more efficiently? Exercise my normal 1 hour a day with these meds, will that be enough to see difference? Or do I need to be doing all weights or what and how much? Everywhere online it talks about the info about the meds, BUT NOWHERE does anybody say what you should do with yourself while on the meds. Make sense?

        • David

          Liz, please check our other articles. You will surely find every tip that you are looking for!

        • Avatar
          Jed Imperial

          Just take cardarine 10mg/day and be in a calorie deficit. You can achieve calorie deficit combining diet with cardio. I suggest watching Greg Doucette, you might not like the way he talks but he’s spitting facts.

    4. Avatar

      Hello I got 1000mg of Ostarine powder. I want to take 20mg a day. Can I just take 20 mg mix with water and drink that per day? Thanks

      • David

        That should be sufficient.

        Remember though about caring over your hormonal balance during Ostarine cycle!

    5. Avatar


      Will ostarine interfere/effect the efficacy of hormonal birth control (the pill). I’m looking to start a cycle but am hesitant due to this concern.

      • David


        It’s really hard to tell. Both the pills and Ostarine are acting on our hormonal balance. You should definitely consult it with your doctor first because no clear researches are dealing with this matter.

    6. Avatar

      Looking to build muscle mass. Have 15mg pills. Split twice daily 1 pill in am and 1 pill before bed. Would I need a PCT after if I do a 4 week cycle?

    7. Avatar

      I start my ost/rad 140 stack tomorrow. I also take 25 mg mk-677 daily and 400mg cypionate weekly. I was on just the jest for 11 years and added the mk-677 this February. Results have been outstanding. Excited to see how the rad 140 and ost add to my gains. A recent study showed a synergistic effect of those two SARMs when on testosterone.

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