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ChromaDex TRU NIAGEN® is a dietary supplement with a patented form of nicotinamide riboside which is is a derivative of vitamin B3. The substance is a precursor to NAD+, helps improve mitochondrial function and inhibits the expression of genes which are critical to ageing processes.
The formulation is recommended especially to individuals who lack energy and vitality and experience fatigue and cognitive decline. It is perfect for middle-aged individuals who want to slow down the body’s ageing and maintain youthful vitality for a long time.
Nicotinamide riboside is one of the forms of vitamin B3. It can be found in some food products, such as brewer’s yeast, cow’s milk and whey protein. It functions as a precursor to NAD and NADP coenzymes which are responsible for the body’s energy balance.
Niagen® is a patented form of nicotinamide riboside in supplements which has been used in most studies on the properties of this compound. It is characterised by high potency and is safe for the body. It is formed from ribose and niacinamide and that is why it does not cause flushing, which is typical of high doses of niacin. The so-called niacin flush is caused by the activation of the receptor HM74A. Nonetheless, only nicotinic acid, i.e. another form of vitamin B3, displays an affinity for this receptor.
The ageing process of the body depends from many factors. Scientists have shown that we can slow it down by activating specific proteins, i.e. sirtuins. They are responsible for controlling gene expression and regulating the lifespan of cells. One of the ways to increase the expression of SIRT1 and SIRT3 is to boost NAD+ levels. Nicotinamide riboside is perfect for this role. Studies have also demonstrated that this compound increases the number of mitochondria and promotes their efficiency. Both their number and function is closely connected with the rate at which body cells will age.
Maintenance of energy balance
Nicotinamide riboside is converted in the body into nicotinamide adenine dinucletotide (NAD+) and its phosphate form (NADP+). Both compounds are involved in cellular respiration and their derivatives function as acceptors of electrons and protons in cellular oxidation processes. They have a key role in transferring energy released from glucose and fatty acids to mitochondria. Without adequate NAD+ levels, energy transfer withing cells is disrupted, resulting in a lack of vitality, fatigue and loss of motivation.
Improved mental performance
A decrease in NAD+ levels may damage your cognitive health. Many persons notice that ageing leads to the impairment of memory and mental performance. Scientists think that nicotinamide riboside may help maintain intellectual health and reduce the risk of neurodegenerative diseases.
So far, most studies have been conducted only on animals. However, they have clearly demonstrated that 3-month supplementation with nicotinamide riboside stimulates the production of new neurons, increases neuroplasticity and prevents nerve cell damage. The effects of nicotinamide riboside on the hippocampus are especially interesting – it seems that it is capable of repairing and preventing DNA damage It is worth noting that this region of the brain is usually damaged in persons with dementia and neurodegenerative diseases.
When you age, your metabolism slows down and it is harder to build and maintain muscle mass. What is more, you develop various metabolic disorders which damage health and contribute to excessive weight gain. Maintaining a healthy weight depends from various factors, but it is easy to see that it becomes more difficult with age.
As shown in studies, nicotinamide riboside may help maintain optimal body weight and reduce the risk of metabolic diseases via many mechanisms. It influences beneficially glucose levels and increases the cells’ sensitivity to insulin. This strategy is effective in fighting type 2 diabetes and obesity. Studies on animals showed that rodents on a fat-rich diet gained 60% less weight when they were given Niagen®.
To sum up, ChromaDex TRU NIAGEN® is an effective weapon against ageing. This process is inevitable, but substances such as nicotinamide riboside may slow it down and reduce its negative effects. The supplement may be taken by young persons who put a heavy strain on the body and may thus feel weak and lack energy and vitality.
Nicotinamide riboside is a naturally occuring form of vitamin B3. It is safe for the body and does not pose the risk of the so-called niacin flush which occurs when you supplement with vitamin B3 in the form nicotinic acid. The supplement should be taken on an empty stomach.
The dosage of 300 mg recommended by the manufacturer is optimal and allows you to enjoy the supplement’s benefits. Nonetheless, studies have shown that even higher doses are safe for the body. It must be used with caution only by patients with liver dysfunction. During long-term supplementation, it is recommended to control regularly levels of alanine transaminase (ALT) as a preventive measure.
ChromaDex is a world-renowned producer of nutraceuticals and distributor of dietary supplements. The company was established in 1999 and is listed on the Nasdaq Stock Market. It cooperates closely with leading universities and research institutes and its portfolio includes several excellent, patented ingredients with health benefits. The main goal of the company’s founders is to find a way to slow down the body’s ageing process and improve the quality of life of middle-aged and elderly individuals.
In 2011, ChromaDex got the exclusive right to produce nicotinamide riboside. It is offered to consumers and distributed as NIAGEN®. It is the only form of nicotinamide riboside in the world which has been scrutinised for safety by the FDA. Flagship products by ChromaDex with this ingredient are TRU NIAGEN® and TRU NIAGEN® PRO.
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|per portion (2 capsules)||amount||%DV|
|NIAGEN® (nicotinamide riboside chloride)||250 mg||**|
Microcrystalline Cellulose, Hypromellose (Vegetarian Capsule).
Niagen (nicotinamide riboside) is a derivative of vitamin B3, required for many many metabolic processes of NAD+ which is involved in many metabolic pathways of our body and is of utmost importance for its normal functioning. NAD+ has an impact on the function of mitochondria, namely cell organelles which are very active when doing sport. It regulates energy metabolism and is vital to normal functioning of the nervous system.
Since niagen helps increase directly NAD+ levels in the body, it contributes to the activation of more proteins – sirtuins which are essential to processes that affect the lifespan. Because of that, this compound may delay ageing of the body. SIRT proteins are also capable of repairing damaged DNA or regulating transcription.
According to scientists, this compound may be used in the future to regenerate the body after radiotherapy and for neurological disorders (Alzheimer’s disease) and kidney and liver diseases.
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