• Nicotinamide riboside as Niagen^®
• Regulates genes responsible for ageing
• Influences positively mitochondrial function
• Boosts levels of energy and youthful vitality
• Does not cause “niacin flush”
• Improves energy metabolism
• Promotes health and longevity
• Strengthens cognitive functions
• Optimises metabolism

ChromaDex TRU NIAGEN^® is a dietary supplement with a patented form of nicotinamide riboside which is is a derivative of vitamin B₃. The substance is a precursor to NAD⁺, helps improve mitochondrial function and inhibits the expression of genes which are critical to ageing processes.

The formulation is recommended especially to individuals who lack energy and vitality and experience fatigue and cognitive decline. It is perfect for middle-aged individuals who want to slow down the body’s ageing and maintain youthful vitality for a long time. 

Nicotinamide riboside is one of the forms of vitamin B₃. It can be found in some food products, such as brewer’s yeast, cow’s milk and whey protein. It functions as a precursor to NAD and NADP coenzymes which are responsible for the body’s energy balance.

Niagen^® is a patented form of nicotinamide riboside in supplements which has been used in most studies on the properties of this compound.  It is characterised by high potency and is safe for the body. It is formed from ribose and niacinamide and that is why it does not cause flushing, which is typical of high doses of niacin. The so-called niacin flush is caused by the activation of the receptor HM74A. Nonetheless, only nicotinic acid, i.e. another form of vitamin B₃, displays an affinity for this receptor. 

Slower ageing  
The ageing process of the body depends from many factors. Scientists have shown that we can slow it down by activating specific proteins, i.e. sirtuins. They are responsible for controlling gene expression and regulating the lifespan of cells. One of the ways to increase the expression of SIRT1 and SIRT3 is to boost NAD⁺ levels. Nicotinamide riboside is perfect for this role. Studies have also demonstrated that this compound increases the number of mitochondria and promotes their efficiency. Both their number and function is closely connected with the rate at which body cells will age.

Maintenance of energy balance  
Nicotinamide riboside is converted in the body into nicotinamide adenine dinucletotide (NAD⁺) and its phosphate form (NADP⁺). Both compounds are involved in cellular respiration and their derivatives function as acceptors of electrons and protons in cellular oxidation processes. They have a key role in transferring energy released from glucose and fatty acids to mitochondria. Without adequate NAD⁺ levels, energy transfer withing cells is disrupted, resulting in a lack of vitality, fatigue and loss of motivation.

Improved mental performance
A decrease in NAD⁺ levels may damage your cognitive health. Many persons notice that ageing leads to the impairment of memory and mental performance. Scientists think that nicotinamide riboside may help maintain intellectual health and reduce the risk of neurodegenerative diseases.

So far, most studies have been conducted only on animals. However, they have clearly demonstrated that 3-month supplementation with nicotinamide riboside stimulates the production of new neurons, increases neuroplasticity and prevents nerve cell damage. The effects of nicotinamide riboside on the hippocampus are especially interesting – it seems that it is capable of repairing and preventing DNA damage  It is worth noting that this region of the brain is usually damaged in persons with dementia and neurodegenerative diseases.

Boosted metabolism 
When you age, your metabolism slows down and it is harder to build and maintain muscle mass. What is more, you develop various metabolic disorders which damage health and contribute to excessive weight gain. Maintaining a healthy weight depends from various factors, but it is easy to see that it becomes more difficult with age.

As shown in studies, nicotinamide riboside may help maintain optimal body weight and reduce the risk of metabolic diseases via many mechanisms. It influences beneficially glucose levels and increases the cells’ sensitivity to insulin. This strategy is effective in fighting type 2 diabetes and obesity. Studies on animals showed that rodents on a fat-rich diet gained 60% less weight when they were given Niagen^®.

To sum up, ChromaDex TRU NIAGEN^® is an effective weapon against ageing. This process is inevitable, but substances such as nicotinamide riboside may slow it down and reduce its negative effects. The supplement may be taken by young persons who put a heavy strain on the body and may thus feel weak and lack energy and vitality.