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P-5-P P-5-P 50mg 90 caps.
Now Foods
17.46 $

P-5-P 50mg 90 caps.

Servings: 50mg 90 caps.

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0.19 $ / serving

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  • A precursor to the active form of vitamin B6 in the form of pyridoxal phosphate
  • Facilitates acquiring energy in tissues with a high metabolism
  • Promotes the proper transformation of macronutrients
  • Helps to optimize the level of neurotransmitters
  • Has a positive effect on cognitive functions
  • Supports the reduction of homocysteine levels
  • Prevents excessive muscle cramps
  • Kosher and vegan-friendly
  • Certified with GMP
  • Free of GMOs

Now Foods P-5-P is the highest quality preparation that is the source of two substances with a synergistic effect on the CNS – pyridoxal 5-phosphate and magnesium. The manufacturer taking into consideration different nutritional preferences placed the effective dose of compounds in a convenient form of vegan capsules with high bioavailability.

Pyridoxal 5-phosphate – it is a precursor to the biologically active form of vitamin B6, with is a cofactor of many enzymatic reactions. The presence of Vitamin B6 is crucial to maintaining the proper physical and mental condition. Its deficiencies may manifest themselves in a lowered mood, hormonal problems, and in the long run, also dysfunction of the cardiovascular system.

Magnesium in the formula TRAACS® bisglycinate is a form of Albion® chelate – the best available form available on the market. Magnesium cations play a supporting role for the vitamin B6 contained in the preparation, and also have a positive effect on muscle condition.

Powerful support of the nervous system functions
A modern approach to supplementation assumes not only care for somatic health. Hygiene of the central nervous system and regulation of the level of neurotransmitters within its structures have also become important. Stress, a diet based on unhealthy products and lack of proper rest are the factors that gradually cause disorders in neurotransmitter secretion. Fortunately, a small correction of the products included in the daily menu can lead to an improvement of the nervous system function.

One of the vitamins with the effect on CNS is vitamin B6 in the form of pyridoxal phosphate. Research indicates that it may help people suffering from depression-related mood disorders. This is due to its positive regulation of the enzyme that converts L-dopa into dopamine. Another activity is to promote the production of serotonin. Both of these substances are responsible for feeling pleasure and joy. In addition, vitamin B6 supports the cognitive functions of the body, which particularly in older people results in an improvement of memory processes.

The magnesium present in the supplement supports the action of pyridoxal phosphate, but in a slightly different area. It has been observed that too low blood concentrations of magnesium correlate with depressive disorders. There is a hypothesis that magnesium cations through the regulation of the function of NDMA receptors may positively affect the well-being of patients.

More efficient metabolic processes
Tissues with high energy demand carry out many metabolic processes, which are controlled by a number of enzymatic proteins. They, in turn, in order to perform the proper job, need coenzymes, which are mostly vitamins and microelements.

Glycolysis is the simplest glucose transformation pathway, whose high activity is particularly visible in muscle cells. It leads to obtaining a small amount of energy in the form of ATP, necessary for the proper work of the working muscles. The magnesium present in the preparation as an activator of some of the enzyme components contributes to the improvement of the efficiency of the transformations leading to the obtaining of metabolic fuel.

The reduced supply of glucose to tissues triggers mechanisms that mobilize high-energy substances. Glycogen is the first metabolically readily available compound. Obtaining glucose molecules from it requires the action of glycogen phosphorylase, an enzyme initiating the degradation process. It is the vitamin B6, or more precisely, pyridoxal phosphate, that acts as its coenzyme, enabling the performance of a catalytic function.

Guards of systemic homeostasis
The multidirectional effects of pyridoxal phosphate seem to be almost infinite. According to research, it plays a supporting role in the sulfur amino acid transformation pathway. Together with folic acid and vitamin B12, it participates in the reduction of homocysteine ​​that is harmful to vascular endothelium. Clinically speaking, the high concentration of this intermediate transformation product also correlates with the risk of atherosclerosis and its serious complications.

It is also worth adding that vitamin B6 is involved in the production of a compound responsible for delivering oxygen to tissues. Due to the activation of the aminolaevulinic acid synthase, it is possible to produce heme, from which the hemoglobin is finally obtained in the transformation pathway.

Magnesium also contributes to the maintenance of homeostasis in the system. The most noticeable magnesium activity occurs in skeletal muscles. Competing with calcium cations, it prevents the excessive excitability of myofibrils. This anchor point is used by the athletes who struggle with nagging muscle cramps during exercise.

In conclusion, Now Foods P-5-P is a preparation intended for daily supplementation for all those who want to comprehensively support functions of the CNS, and also want to take care of the "metabolic health" of cells. The combination of substances with a similar profile of action allowed placing them in a convenient form of capsules, which are also vegan-friendly.

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Container size: 90 capsulesServing size: 1 capsuleServings per container: 90
per 1 capsuleamount%DV
Vitamin B-6 [from 50 mg Coenzyme Pyridoxal-5-Phosphate (P-5-P) Monohydrate]33 mg1941%
Magnesium (from Magnesium Bisglycinate) (TRAACS®)25 mg**

Other ingrednients

Rice Flour, Cellulose (capsule), Cellulose Powder, Stearic Acid (vegetable source) and Silica.


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Vitamin B6


Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).


Pyridoxal 5-phosphate (P-5-P)


Pyridoxal 5-phosphate (P-5-P) - the form of vitamin B6, called coenzymatic, considered the best assimilable form of this vitamin by the human organism. This is related to direct metabolic activity of pyridoxal-5-phosphate in the human organism. It does not have to be subjected to biochemical transformations in the organism in order to be able to enter metabolic pathways as a biologically active ingredient.

Vitamin B6 is an incredibly important factor regulating the work of many processes in the organism due to its role in the organism as a coenzyme, essential for the activation of many important enzymes. Thanks to this, it regulates metabolism at many levels and its proper supply is conducive to maintaining homeostasis of the organism.

Another aspect of effectiveness of vitamin B6 is its influence on the normalization of emotional states. It is conducive to relaxation, facilitates falling asleep and falling in a deep, the most valuable sleep. Special influence on P5P on the psyche is proven in women before menstruation, as it demonstrates considerable ability to reduce the symptoms of the pre-menstrual syndrome.

Supplementation with vitamin B6 also demonstrates positive influence on the functions of the nervous system. It is conducive to the nourishment of neuronal tissues and optimizes the secretion of neurotransmitters, thanks to which it promotes nervous transmission and demonstrates neuroprotective properties. It was proven that vitamin B6 may decrease the risk of developing Parkinson’s disease.

Some sources also suggest the ability of pyridoxal 5-phosphate to reduce the risk of cancer. This effectiveness is noted especially in relation to breast cancer.




Magnesium (element from the group of alkaline earth metals, atomic no. 12, a chemical symbol - Mg), one of the most important health microelements, participates in the synthesis process of the disintegration of high energy compounds and processes of transformation of hydrocarbons and fats. It affects the dilation of blood vessels and lower blood pressure, prevents hypercoagulable state. Shortages affect cardiac arrhythmias, malignant muscle cramps, insomnia and anxiety. It is a component of many dietary supplements and found in foods such as whole grain bread, legumes, buckwheat, rice, fish, meat, as well as chocolate, cocoa and nuts.
Dosage of 100 - 500 mg / day



TRAACS® stands for "The Real Amino Acid Chelate System". It is a branded trade name coined by Albion® Human Nutrition – a leading producer of chelated minerals. The company uses the ultra-modern – protected by numerous patents – method that enables combining mineral components with ligands, to create organic, highly bioavailable and easily absorbable mineral chelates.

TRAACS® amino acid mineral chelates have a ring structure and are characterized by an extremely low molecular weight. The mineral is trapped between two molecules of amino acids and attached to them by means of covalent bonds. This ensures the minerals high chemical stability and resistance to the acidic and alkaline environment of the gastrointestinal tract. They can easily reach the small intestine, where they are absorbed.

The success of the minerals marked with the TRAACS® trademark has been built thanks to a renowned producer, hundreds of scientific studies, thousands of laboratory tests and over 70 patents in the field of minerals. They are compliant with the definition of the National Nutrition Foods Association (NNFA) and have been granted the registration number of the American Chemical Society. They are undoubtedly one of the safest and best-absorbed minerals that can be found in oral dietary supplements.

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