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Prime Nutrition Yohimbine is a modern, high-class formula with yohimbine hydrochloride, a salt of yohimbine with excellent bioavailability. It is a compound with outstanding activity which is one of the leading basic ingredients on the market of fat burners. Because of a wide spectrum of effects, yohimbine is taken nowadays by almost every athlete.
Yohimbine hhydrochloride – a well soluble salt of polycyclic indole alkaloid that is biogenetically related to tryptophan and tryptamine. Yohimbine is derived mainly from dry stems and branches of Pausinystalia johimbe (Yohimbe). It is a sympatholytic with a characteristic and specific peripheral effect which is closely connected with its dose. In small doses, it inhibits selectively presynaptic α2-adrenergic receptors (the most desirable effect). By increasing the dosage, it acts as an antagonist of postsynaptic α1-adrenergicand serotonin receptors. This is because of far-reaching effects of yohimbine on the body.
Yohimbine is a stimulator of physiological lipolytic processes. This is connected primarily with its ability to target selectively α2-adrenergic receptors which are responsible for regulating the secretion of noradrenaline and other catecholamines. Their blockage leads to an increase in the activity of the enzyme adenyl cyclase and subsequently levels of cAMP, an intracellular messenger.
Adipocytes, which are stimulated in signal transduction, begin to break down triglycerides of higher fatty acids in an exogenous reaction into energy metabolites that are consequently released into the bloodstream. This process known as thermogenesis is critical to body fat reduction and its origin affects the course of lipolysis. The mechanism of action of yohimbine differs from most compound with similar effects. This is undoubtedly its advantage and facilitates the breakdown of even the most stubborn and accumulated fat when any other agents are not effective.
Yohimbine stimulates the central nervous system and increases natural efficiency of the body. This compound is desired in pre-workout supplements because it shows synergistic effects with many nootropics. By increasing catecholamine levels (especially adrenaline and noradrenaline), it contributes to an increase in the activity of the sympathetic nervous system, which is responsible for stimulation of the whole body, raising its readiness for action. The inhibition of serotonergic receptors plays also a major role in this mechanism – their insensitivity to endogenous ligands leads to faster mobilisation.
In addition, presynaptic inhibition of α2-adregnergic receptors contributes to an increase in the production of NO, a gaseous neurotransmitter responsible for the relaxation of blood vessels (vasodilating properties). An increase in arterial lumen promotes the flow of blood rich in nutrients through vessels that cover muscle tissue. This improves efficiency and speeds up recovery.
Yohimbine has been always used for sexual dysfunction. Due to spasmolytic properties, which help dilate blood vessels, in particular in the abdominal cavity, and raise systolic pressure, it improves the flow and accumulation of blood in cavernous bodies Its supplementation is effective in most cases of impotence and side effects are less harmful than in other similar agents and drugs.
It has been shown that taking yohimbine boosts libido, regardless of testosterone levels. Because of that, this substance is used to promote the treatment of psychiatric sexual disorders and those caused by opioids and antidepressants.
To sum up, Prime Nutrition Yohimbine is a product with a wide range of uses and tested and proven activity. It is recommended during a reducing diet to finally get rid of accumulated fat at its last stages. It will be also effective as an element of pre-workout supplementation, reducing fatigue and boosting muscle efficiency and nourishment during and after a workout.
The recommended effective dose should not exceed 0.2 mg per kg of body weight. On the basis of this assumption, you can estimate the supplement’s dosage for your weight and divide it into 3 daily doses.
It is the most important to take it on an empty stomach because food reduces significantly its absportion and efficacy.
Remember to maintain adequate hydration during supplementation. The formula should not be taken at night because it may cause difficulties in falling asleep and impair sleep quality.
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|per portion (1 capsule)||amount||%DV|
|Yohimbine HCL||2.5 mg||*|
Gelatin (Capsule), Magnesium Stearate, Silicon Dioxide.
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