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Methyldrene ECA Methyldrene ECA 100 caps.
Cloma Pharma
40.73 $

Methyldrene ECA 100 caps.

Servings: 100 caps.
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  • A unique and comprehensive formula
  • A powerful dose of "ECA stack"
  • A powerful and effective fat burner
  • Stimulates the nervous system
  • Boosts energy and motivation
  • Accelerates metabolism
  • Increases thermogenesis
  • Strongly suppresses appetite
  • Contains synephrine, yohimbine, and 5-HTP

Cloma Pharma Methyldrene ECA is one of the strongest fat burners available on the sports supplement market. It contains only synergistically acting ingredients, whose effectiveness has been confirmed by many scientific studies. A powerful dose of the proprietary blend, "ECA", makes it one of the best products of its kind.

"ECA" Blend is a legendary combination of ingredients used for maximum fat loss. It is a strong thermogenic agent consisting of Ephedra viridis, caffeine and salicin derived from white willow bark extract. The effectiveness of "ECA" in slimming is indisputable and confirmed in numerous clinical trials, as well as many years of experience of users and athletes.

Cloma Pharma Methyldrene ECA consists of the following ingredients

Ephedra viridis (leaf extract) – a plant species belonging to the Ephedra family. It contains naturally occurring alkaloids, belonging to the group of stimulants that stimulate the central and peripheral nervous system. Ephedra extract reduces appetite and accelerates metabolism (and thus energy expenditure), increases thermogenesis, stimulates the release of fat from fat cells, increases motivation for physical activity and boosts energy.

Caffeine anhydrous – a purine alkaloid with psychoactive effect; it occurs naturally, among others, in coffee, tea, guarana, yerba mate and cocoa, but it can be also obtained synthetically. It belongs to the group of stimulants, i.e. substances that stimulate the activity of the sympathetic and central nervous system (CNS).

Caffeine increases metabolism, i.e. the overall energy transformations of the body and promotes lipolysis, i.e. the breakdown of triglycerides in adipose tissue. By blocking adenosine receptors, it prevents drowsiness and reduces fatigue.

White willow bark, the so-called "natural aspirin", is a source of salicin, which has anti-inflammatory and analgesic properties. Along with caffeine and Ephedra viridis extract, it is part of the "ECA" stack, i.e. a very effective fat burner.

Salicin breaks down in the body into salicylic acid that can activate the AMP-dependent kinase enzyme (AMPK), which increases the influx of energy substrates into muscle cells and intensifies their burning. This leads to the increase of the body's energy expenditure – including fat loss.

Bitter orange extract (Citrus aurantium extract) – contains synephrine (a natural analog of ephedrine), which stimulates the sympathetic nervous system similarly to adrenaline. It activates some of the adrenergic receptors: alpha-1 and beta-3, thus inducing lipolysis (fat breakdown) with simultaneous activation of thermogenesis.

Synephrine is more and more often added to supplements and preparations designed for athletes and obese people. Manufacturers are even proud that they make products containing ephedra-like substances which are free of banned ephedrine.

Panax/Korean ginseng (root extract) – a medicinal plant used in Chinese medicine for almost 4.000 years. It contains numerous flavonoids, nitrogen compounds, fatty acids, vitamins and bioactive ginsenosides classified as saponins. It belongs to the group of adaptogens, i.e. herbal substances (extracts) supporting the body's resistance to stress stimuli and traumatic experiences, used in states of fatigue or anxiety. It supports weight loss through its specific ability to lower blood glucose, thereby improving insulin and glucose management.

Ginger root powder contains shogaols and gingerols – polyphenols that are structurally similar to noradrenaline and exhibiting properties that support fat burning. It promotes losing weight, because it belongs to thermogenic compounds, which, by increasing the release of heat energy, stimulate the body's energy expenditure.

Barbary fig (Opuntia Ficus Indica), otherwise known as the Indian fig, is a cacti variety, occurring naturally e.g. in Mexico. Its fruits contain pulp, which supports the work of the pancreas and helps to reduce blood glucose. Besides, it is a source of fiber, thanks to which it influences lipid profile normalization, as well as it can bind with fat from food, facilitating weight loss.

Cayenne pepper (Cayenne fruit extract) – obtained from hot chili pepper; it contains capsaicin (an alkaloid that acts on the vanilloid receptor). It causes adrenaline and noradrenaline (catecholamines) release from the adrenal medulla, and consequently increases metabolism and intensifies the lipolysis process.

Green tea leaf extract – it is a concentrate containing biologically active compounds: polyphenols (e.g. catechin, in the form of EGCG – epigallocatechin gallate), showing antioxidant properties and slight thermogenic potential.

Cocoa extract – obtained from cocoa beans; it contains theobromine – a purine alkaloid, which along with polyphenols and caffeine increases the thermogenic potential, allowing for an increase in energy expenditure and acceleration of the reduction of body fat.

Yohimbe bark extract contains yohimbine, an alkaloid that exerts stimulating properties. It selectively blocks alpha-2 adrenergic receptors, thus making adrenaline and norepinephrine oriented on stimulating lipolysis – the process of triglyceride breakdown into fatty acids and glycerol, which in this form can be included in energy acquisition processes.

African black bean seed extract (Griffonia seed extract) contains 5-HTP (5-hydroxytryptophan) – an aromatic amino acid naturally produced by the body from the exogenous (essential) amino acid – L-tryptophan. It has been used for over 30 years for therapeutic reasons, due to its specific ability to increase the production of serotonin in the brain.

Clinical studies in obese patients have shown that the use of 5-HTP resulted in a decrease in food intake (reduction of appetite) and thus weight loss.

All this makes 5-HTP prove to be very helpful during restrictive slimming diets, when both the amount of tryptophan and serotonin decrease sharply, which results in increased carbohydrate craving and, consequently, excessive calorie intake. 5-HTP counteracts the craving for carbohydrates (including sweets), and thus helps to reduce appetite and calories consumed.

Moreover, the preparation contains vitamins B6, B12, and chromium, which support energy metabolism, help to maintain normal blood glucose levels and improve the functioning of the nervous system.

In summary, Cloma Pharma Methyldrene ECA is an extremely effective fat burner that works through various metabolic pathways. Due to the strongest composition of ingredients available on the market, the preparation is intended only for advanced users and athletes.

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Container size: 100 capsulesServing size: 1 capsuleServings per container: 100
per 1 capsuleamount%DV
Vitamin B6 (as pyridoxine HCl)2 mg118%
Vitamin B12 (as cyanocobalamin)6 mcg250%
Chromium (as chromium picolinate)30 mcg86%
ECA Blend375 mg-
Caffeine Anhydrous250 mg-
White Willow Bark Powder (25% Salicins)100 mg-
Ephedra Viridis Leaf25 mg-
Methyldrene Fat-Burning Support System298 mg-
Citrus aurantium extract (fruit) (30% synephrine)50 mg-
Panax ginseng extract (root) (4% ginsenosides)50 mg-
Ginger (Root) Powder38 mg-
Cocoa (Theobromine Cocoa) (Fruit) Extract (20% Theobromine)35 mg-
Cayenne Pepper (Fruit) 40,000 Heat Units Powder35 mg-
Cactus Cladods (as Opuntia Ficus Indica) Powder35 mg-
Green Tea (Leaf) Extract (95% Polyphenois)35 mg-
Yohimbe (Pausinystalia Yohimbe) (Bark) Extract (8% Yohimbine)19 mg-
Griffonia Seed Extract (Source of 5-HTP)1 mg-

Other ingrednients

Gelatin, Silicon Dioxide, Magnesium stearate (Vegetable), FD&C Yellow #5, Titanium dioxide

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Vitamin B6


Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).




What is cyanocobalamin?

Cyanocobalamin is a basic, the most commonly met form of vitamin B12 in vitamin B complexes and multivitamins available on the market.

Vitamin B12 is the most known for its influence on neurology. It takes part in building and regenerating myelin sheaths of neurons, thanks to which it contributes to the protection of the nervous system against damages. Because of the ability to increase the level of S-Adenosyl methionine, vitamin B12 may contribute to more efficient synthesis of many neurotransmitters, thanks to which it positively influences well-being and psychical condition.

This vitamin is also engaged in the process of blood production and its deficiencies contribute to the creation of megaloblastic anemia. Its deficits may also concern vegetarians and vegans, elderly people, people with absorption disorders and those using drugs neutralizing gastric acid.

Cyanocobalamin is included in the composition of many complex vitamin supplements that may be found in the offer of



Chromium (chemical element from transition group of the chromium, chemically active) is actively involved in the metabolism of fats and carbohydrates. It comes in the easily assimilable organic form and inorganic. Along with insulin, as a component of the glucose tolerance factor (GTF), is used in insulin-dependent diabetes treatment, insulin involved in the metabolism of glucose in t proteins transport. Activator of enzymes involved in the metabolism of fats and cholesterol. Available in animal origin products (liver, veal, chicken, turkey meat, oysters) and plant-origin (bananas, broccoli, cereal, wheat germ, spinach). Supplements containing chromium are recommended for fat loss (also thermogenic), and improving the functioning of the body. The sports supplementation used chromium in the form of mono-preparations or in the form of vitamin-mineral minerals supplements.
Chromium deficiency results in impaired glucose, reducing the insulin sensitivity. It causes a decrease in immunity and endurance of the body. It may be a cause of coronary heart disease. Sometimes it causes neurological disorders.
Dosage: A varied diet prevents from the deficiency of chromium in the body.

Dosage: The recommended dose of 50-150 mg per day.


Chromium Picolinate


Chromium Picolinate is a complex containing trivalent chromium and picolinic acid, for greater assimilation, it has chelating and anti-inflammatory properties. Trivalent chromium is a part of the glucose tolerance factor (GTF), supporting the anabolic effect of insulin in the creatine transport into the muscle cells. Chromium is used to treat type 1 diabetes melitus, and with insulin it is involved in the metabolism of glucose it transport of protein. It is an activator of enzymes involved in the metabolism of fats and cholesterol. Chromium picolinate is used by people active beyond sports and in sports supplementation as fat burners affecting fat reduction, weight loss, as well as a compound which enhances uptake of nutrients by muscle cells and the vitamin and mineralizing supplements, available www.muscle-zone. pl



Caffeine (1,3,7-trimethylxanthine, 1-methylotheobromine) is a purine alkaloid occurring in the natural state in plants (Coffea arabica, Camelia sinensis, Paulinia cupana, Ilex paraguariensis), which acts as a natural pesticide, acting toxic to insects. Peculiar smell and taste also deters herbivores. Caffeine in the body inhibits the adenosine receptors in the brain, fighting fatigue and allowing for action activation. It has a beneficial effect on the metabolism of oxygen, which increases the exercise capacity (strength and endurance) and rapid post-workout recovery. In the sports supplementation, caffeine is used as a stimulant nervous system. It has the thermogenic potential and in combination with other substances (e.g. Polyphenols, both occurring in coffee beans, such as cocoa beans, tea leaves and mate) can effectively participate in the reduction of body fat. It is included in many dietary stimulants (creatine stacks, no-boosters, beverages). It is a component of fat burners. It is also in the form of mono-preparation supplements.
Dosage: 100-600 mg per day. Due to the long release of activity should not be used in the evening, before


White willow


White willow (Salix alba) [and the related species] due to anti-inflammatory, analgesic and anti-thrombotic properties of its bark (Cortex Salicis) is used as a raw medicinal material containing natural salicylic acid (increased availability, and minimized possibility of allergies), phenolic glycosides, catechin tannins and minerals. Formulations of the white willow bark are useful in the treatment of diarrhea, inflammation of the body at elevated temperatures and certain rheumatic diseases. Powdered white willow bark is used as a cosmetic allowing to reduce the sweating of feet. Due to the thermogenic potential it is used in the blends and on-weight loss supplements available at
Dosage: no individual standards of daily consumption

Ephedra Viridis


Ephedra Viridis – a plant known also as green Mormon tea or Green ephedra, gaining popularity since banning its relative Ephedra sinica by FDA. It contains alkaloids with thermogenic properties and thus increases the body’s energy expenditure, thereby creating a larger calorie deficit. It is therefore an effective way to speed up fat burning. Because of its activity, Ephedra viridis extracts are a frequent additive to fat burners.

Some sources report that supplementation with Green ephedra curbs the appetite. It helps stick to a diet, especially during low calorie intake.

In addition, it is that Ephedra viridid is a source of flavonoids capable of reducing the amount of free radicals in the body. Owing to that, supplements with this plant extract reduce oxidative stress, thereby promoting health.



Fat is an essential nutrient plant and animal organisms. Because of the nutritional value and composition of fats are divided into: saturated (mono-saturated and multi-saturated fatty acids) and unsaturated fatty acids (including essential fatty acids - EFA). The group of lipids include lipids (triacylglycerols, waxes), complex fats (glycolipids, phospholipids), sterols and isoprenoids. Saturated fatty acids is a group of fatty acids having different carbon chain lengths, in which except for the carboxyl group, each of the carbon atoms is bound by a single bond. May adversely affect the lipid profile, so they can be used in limited quantities. Fats are a concentrated source of energy, with different flavours, facilitating the consumption and swallowing of food. They have building functions (part of cell membranes and co-create the white matter of the brain). EFAs are precursors of tissue hormones and biologically active compounds. The unsaturated fatty acids include fatty acids from the group Omega-3, Omega-6 and Omega-9 (the last digit indicates, on which, counting of the end of the chain, there is a double bond in the appropriate carbon chain. The essential fatty acids include: acids, medium-Omega-3 [n-3 ] included in EFAs [essential fatty acids], and long chain (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) Omega-6 and Omega-9. the number indicates that the last double bond in the carbon chain is on the third from the end carbon atom. The acids from the omega 3 group are essential components of cell membranes, they are precursors of eicosanoids and biological activators. They must be combined with ingestion in suitable proportions of Omega-6 acids.
Dosage: Depending on demand and applied diet. It is generally accepted that fats should constitute 20-30% of the energy (calorie) of meals daily.


Citrus aurantium extract


Citrus aurantium extract (Bitter orange extract) is widely used in weight reduction process, among athletes, active individuals and people with so called sedentary life-style. It is a source of synephrine and octopamine, which in combination with caffeine and polyphenols contained in green tea affect lipolysis, releasing fatty acids from adipocytes, causing increased energy expenditure, burning them in the sources of cells vital energy (mitochondria). It became popular after the banning ephedine (dangerous for the body) by WADA .
The extract of bitter orange is part of the weight loss
supplements (I.e. thermogenics), pre-workout creatine stacks and nitrogen boosters.
Dosage: No specific standards of daily consumption. At high hypertension and
with medicines containing a statin, extract of bitter orange should not be used.




Synephrine is an organic compound from harvested on an industrial scale the fruit of bitter orange (Citrus aurantium). Citrus auratuim extract (extract of bitter orange) is widely used in the process of weight reduction, both among athletes, active individuals, as well as leading the so-called. "sedentary lifestyle". It is a source of synephrine and octopamine, which in combination with caffeine and polyphenols contained in green tea affect lipolysis, releasing fatty acids adipocytes, by causing increased energy expenditure, burning them in the sources of vital energy cells (mitochondria). It is popular on the banning of ephedra by WADA (dangerous for the body). Contraindication to use preparations against people with hypertension. In the sports supplementation is available in body mass reduction and sculpting programs, as a thermogenic, creatine stacks and nitrogen boosters ingredient.
Dosage: No standards unit consumption. In the supplementation - customarily - 10-30 mg




Ginsenosides (triterpene saponins) are biologically active ingredient in ginseng root, its leaves and generative organs. Improve the oxygenation of the tissues of the body, affecting the increase in exercise capacity during the psychophysical effort. An antibacterial and antiviral strengthening immunity. By antioxidant action, limit the development of free radicals and membrane protein brain. Improve sexual ability. Used in sports supplementation at different levels of training. Improve concentration and ability to memorize. Available in mono-preparation supplement and herbal blends, herbal-mineralizing and herbal vitaminizing blends.
Dosage: 10-50 mg per day.

Ginger root


Ginger root (Zingiber Officinale Radix) as a herbal raw material is widely used as a source of, among others, gingerols. Compounds containing organic components of ginger root are characterized by high biological activity. Ginger root is used in medicine, due to the prevention of infection, to ensure a balance of gastrointestinal bacteria, involved in the production of bile. It has a beneficial effect on the functioning of the circulatory system as an antioxidant, lowers blood pressure, causing a delay in the processes of formation of LDL cholesterol (inhibitor). As a thermogenic it reduces appetite processes and sometimes it is a component of weight loss complexes. Through participation in the transformation of thermogenic lipolysis, is one of the valuable fat burners. The active substances contained in it are a component of arthritis regenerators (in combination with glucosamine including or curcumin). In the sports supplementation it is valued for its anti-inflammatory properties to support the process of healing and recovery after an injury of motor organs (especially the joints). It co-creates so called joints regenerators with chondroitin, glucosamine and curcumin.



Theobromine (3,7-Dimethylxanthine) is a purine alkaloid, poorly soluble in water, present in cocoa beans, as well as the leaves of yerba mate, tea, coffee, cola and peanuts. It is a diuretic, lowers blood pressure and improves brain function (dilates the blood vessels of the brain). Also expands the blood vessels throughout the circulatory system, preventing atherosclerotic changes. Sometimes it is used in slimming diet. Combined with caffeine and polyphenols becomes thermogenic. In the sports supplementation formulations containing theobromine are used diuretics and fat burners. It is a component of thermogenics, pre-workout creatine stacks, as well as nitrogen boosters.

Cayenne pepper


Cayenne pepper - derived from hot peppers chilli, is not only the kitchen spice, but also a component of supplements. It contains capsaicin (an alkaloid which affects the vanilloid receptor, causing the feeling of warming). The increase in temperature causes the release of adrenaline and noradrenaline (catecholamines) from the adrenal medulla, and the consequent increase of metabolism and intensity of the lipolysis (resulting in reduction of adipose tissue) and is applicable in slimming diets (especially for people with low physical activity). It should not be combined with preparations containing capsaicin and casein (dairy) in one meal, as casein will cause the degradation, as it is an inhibitor of capsaicin. In the supplementation it is used as mono-preparation supplement or ingredient of supplements reducing body fat, available at
Dosage: usually 25 - 100 mg / 24h



Yohimbine is a natural component of the indole alkaloid yohimbine, ingredient of bark of yohimbe (Corynanthe yohimbe), a recognized aphrodisiac and increasing potency mean. It stimulates the nervous system by blocking the adrenergic receptors alpha-2. Tree bark of yohimbe is also a source of alkaloids (isoyohimbine, aloyohimbine), which can enhance its performance. With the right dosage, taken with caffeine on an empty stomach and a longer period before taking a meal, it enhances the process of lipolysis due to increased levels of norepinephrine in the body.
In the sports supplementation
it helps to reduce body fat (especially in programs of weight control and its composition), taken before physical activity. It comes in the form of mono-preparation supplements, extracts from yohimbe tree bark, synthetics and in supplements with thermogenic effect. Available for purchase at
Dosage: No specific dosage standards. Some sources give optimal dose of 0.2 mg / kg
of body weight (usually used at 5-10 mg per day).


Griffonia Seed Extract


Griffonia Seed Extract (extract of griffonia grain), a source of derivative of tryptophan, 5-hydroxytryptophan (5-HTP), involved in the synthesis of serotonin (a neurotransmitter, and so. "Happiness hormone"), a relaxing action and affecting indirectly to the creation of melatonin, a hormone regulating the quality and depth of sleep. The extract is used both in traditional medicine and pharmacological treatment as an anti-stress, depression, and insomnia remedy . In the sports supplementation it is used due to the increasing levels of the neurotransmitters that enhances mood, the quality and depth of sleep and increasing body recovery It is also a component of dietary appetite suppressants.
Dosage: From a few dozen to several hundred mg per day (based on 5-HTP).


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