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Lipodrene Hardcore Lipodrene Hardcore

Hi-Tech Pharmaceuticals Lipodrene Hardcore is a complex of ingredients containing a range of plant extracts and isolated active substances, which in an effective way ensure increasing metabolic rate, effective fat burning and they contribute to delaying the feeling of hunger.

Ephedra leaf extract is the source of natural ephedrine and pseudoephedrine - the substances influencing the receptors of the adrenergic system. The first one works mainly by means of beta receptors and may contribute to the increased production of heat in muscle tissue, stimulating at the same time burning energy substrates, i.a. fats released from adipocytes. Moreover, it may decrease glucose uptake by adipose tissue cells, preventing the storage of spare substrates. The main effect of the activity of pseudoephedrine is the increase of blood pressure, thanks to the fact that it binds with alpha receptors on pre-capillary sphincters of vessels.

Senegalia Berlanderi leaf extract - contains N-methyl phenylethylamine, tyramine and phenylethylamine, which are the substances with a central effect. They facilitate adrenergic transmission, mainly for adrenaline, which contributes to increased peripheral lipolysis. Moreover, phenylethylamine and its derivatives are known for its euphoria-causing effect, thanks to which they improve mood.

Citrus Aurantium extract is the main source of phenylethylamine, which on a molecular level binds with TAAR1 receptors in the central nervous system, inhibiting reuptake of dopamine, serotonin and noradrenaline. Dopamine and serotonin as the “happiness hormones” are responsible for mood improvement and pleasure while noradrenaline increases blood pressure and helps to release triglycerides from adipocytes.

Theophylline anhydrous is a substance, similarly to caffeine, belonging to methylxanthines - a group of chemical compounds, which cause the increase of intracellular cAMP inside adipocytes, at the same time launching the enzymatic apparatus, essential for fat “utilization”. Additionally, it may increase blood pressure, but at the same time it has protective influence on kidneys, improving blood flow through them; it also relaxes smooth muscles of bronchial tubes, facilitating breathing.

Cassia Nomame extract demonstrates inhibiting influence on the activity of the enzyme called pancreatic lipase, which takes part in the process of the breakdown of digestive fats - thanks to which, it is possible to “break them down” into monoglycerides and fatty acids, absorbed in the small intestine. Lack of this process decreases the amount of calories provided with food, at the same time facilitating the achievement of calorie deficit and fat reduction by starting the processes of lipolysis.

Naringen - is a compound of plant origin from the group of flavonoids, which demonstrates a wide spectrum of effects. It helps to fight the excess of fatty tissue and disorders of the lipid panel, as it may induce apoptosis of adipocytes and inhibit one of the key enzymes in the production of cholesterol - reductase HMG-CoA. Moreover, its anti-inflammatory and antioxidant effect was proven.

6,7-dihydroxybergamottin - is contained in grapefruit juice and has unique inhibiting activity in relation to the enzymatic complex in the liver - called cytochrome P450. It is responsible for the metabolism of many substances, including drugs. As an additive to supplements, its task it to facilitate their bioavailability.

Evodiamine - is an alkaloid isolated from the fruit occurring in China. It contributes to the increased production of catecholamines, which directly increase the concentration of cAMP in cells of adipose tissue, thanks to which their clearing is possible.

5-Methoxytryptamine hydrochloride - is a full agonist of serotonin receptors in the central nervous system. This compound is attributed the ability to influence leptin secretion - the “satiety hormone”, which prevents excessive snacking and facilitates body mass control.

Yohimbe extract - is characterized by the presence of yohimbine, a chemical compound which works like an antagonist of alpha2 receptors, thanks to which, without the inhibiting effect, it enables noradrenaline secretion. The substances from the family of polyphenols and other chemical compounds present in the extract contribute to the improvement of insulin sensitivity of cells, lipid profile of blood and quieting existing inflammatory processes.

Guayusa extract is another plant extract containing methylxanthines, which may considerably intensify lipolytic effect of other compounds.

Green tea extract a rich source of ingredients, primarily methylxanthines as well as epicatechins. The latter contribute to i.a. decreasing the feeling of hunger both by the influence on the secretion of neurotransmitters, but also by delaying stomach emptying. They may also sensitize tissues to the activity of insulin.

Theobroma Cacao extract – the source of theobromine, methylxanthine, which apart from its participation in burning fatty tissue enables more effective absorption of epicatechins contained in greet tea extract. It also improves lipid profile, has anti-inflammatory effect and may also decrease blood pressure.

To sum up, Hi-Tech Pharmaceuticals Lipodrene Hardcore is a supplement which is mainly addressed to people, who want to intensify the process of burning fat. The combination of ingredients inducing the secretion of catecholamines and methylxanthines will allow to start enzymatic process of lipolysis and polyphenols, epicatechins and pancreas lipase inhibitors contribute to additional effects in the form of delaying hunger, sensitizing cells to insulin, which decreases the intake of calories.

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Lipodrene Hardcore Lipodrene Hardcore 90 tab. (US version)
Hi-tech
42.92 $

Lipodrene Hardcore 90 tab. (US version)

Servings: 90 tab. (US version)

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Description
  • Complex of substances maximising stimulation and motivation
  • Maximises the rate of burning excess body fat
  • Stimulates physiological mechanisms of fat burning
  • Helps limit the absorption of unnecessary calories
  • Inhibits harmful inflammatory processes
  • Maintains insulin-carbohydrate balance
  • Decreases the production of “bad” cholesterol
  • Intensifies cAMP production
  • Safe to use
  • Relieves hunger
  • DMAA free!

Hi-Tech Pharmaceuticals Lipodrene Hardcore is a complex of ingredients containing a range of plant extracts and isolated active substances, which in an effective way ensure increasing metabolic rate, effective fat burning and they contribute to delaying the feeling of hunger.

Ephedra leaf extract is the source of natural ephedrine and pseudoephedrine - the substances influencing the receptors of the adrenergic system. The first one works mainly by means of beta receptors and may contribute to the increased production of heat in muscle tissue, stimulating at the same time burning energy substrates, i.a. fats released from adipocytes. Moreover, it may decrease glucose uptake by adipose tissue cells, preventing the storage of spare substrates. The main effect of the activity of pseudoephedrine is the increase of blood pressure, thanks to the fact that it binds with alpha receptors on pre-capillary sphincters of vessels.

Senegalia Berlanderi leaf extract - contains N-methyl phenylethylamine, tyramine and phenylethylamine, which are the substances with a central effect. They facilitate adrenergic transmission, mainly for adrenaline, which contributes to increased peripheral lipolysis. Moreover, phenylethylamine and its derivatives are known for its euphoria-causing effect, thanks to which they improve mood.

Citrus Aurantium extract is the main source of phenylethylamine, which on a molecular level binds with TAAR1 receptors in the central nervous system, inhibiting reuptake of dopamine, serotonin and noradrenaline. Dopamine and serotonin as the “happiness hormones” are responsible for mood improvement and pleasure while noradrenaline increases blood pressure and helps to release triglycerides from adipocytes.

Theophylline anhydrous is a substance, similarly to caffeine, belonging to methylxanthines - a group of chemical compounds, which cause the increase of intracellular cAMP inside adipocytes, at the same time launching the enzymatic apparatus, essential for fat “utilization”. Additionally, it may increase blood pressure, but at the same time it has protective influence on kidneys, improving blood flow through them; it also relaxes smooth muscles of bronchial tubes, facilitating breathing.

Cassia Nomame extract demonstrates inhibiting influence on the activity of the enzyme called pancreatic lipase, which takes part in the process of the breakdown of digestive fats - thanks to which, it is possible to “break them down” into monoglycerides and fatty acids, absorbed in the small intestine. Lack of this process decreases the amount of calories provided with food, at the same time facilitating the achievement of calorie deficit and fat reduction by starting the processes of lipolysis.

Naringen - is a compound of plant origin from the group of flavonoids, which demonstrates a wide spectrum of effects. It helps to fight the excess of fatty tissue and disorders of the lipid panel, as it may induce apoptosis of adipocytes and inhibit one of the key enzymes in the production of cholesterol - reductase HMG-CoA. Moreover, its anti-inflammatory and antioxidant effect was proven.

6,7-dihydroxybergamottin - is contained in grapefruit juice and has unique inhibiting activity in relation to the enzymatic complex in the liver - called cytochrome P450. It is responsible for the metabolism of many substances, including drugs. As an additive to supplements, its task it to facilitate their bioavailability.

Evodiamine - is an alkaloid isolated from the fruit occurring in China. It contributes to the increased production of catecholamines, which directly increase the concentration of cAMP in cells of adipose tissue, thanks to which their clearing is possible.

5-Methoxytryptamine hydrochloride - is a full agonist of serotonin receptors in the central nervous system. This compound is attributed the ability to influence leptin secretion - the “satiety hormone”, which prevents excessive snacking and facilitates body mass control.

Yohimbe extract - is characterized by the presence of yohimbine, a chemical compound which works like an antagonist of alpha2 receptors, thanks to which, without the inhibiting effect, it enables noradrenaline secretion. The substances from the family of polyphenols and other chemical compounds present in the extract contribute to the improvement of insulin sensitivity of cells, lipid profile of blood and quieting existing inflammatory processes.

Guayusa extract is another plant extract containing methylxanthines, which may considerably intensify lipolytic effect of other compounds.

Green tea extract a rich source of ingredients, primarily methylxanthines as well as epicatechins. The latter contribute to i.a. decreasing the feeling of hunger both by the influence on the secretion of neurotransmitters, but also by delaying stomach emptying. They may also sensitize tissues to the activity of insulin.

Theobroma Cacao extract – the source of theobromine, methylxanthine, which apart from its participation in burning fatty tissue enables more effective absorption of epicatechins contained in greet tea extract. It also improves lipid profile, has anti-inflammatory effect and may also decrease blood pressure.

To sum up, Hi-Tech Pharmaceuticals Lipodrene Hardcore is a supplement which is mainly addressed to people, who want to intensify the process of burning fat. The combination of ingredients inducing the secretion of catecholamines and methylxanthines will allow to start enzymatic process of lipolysis and polyphenols, epicatechins and pancreas lipase inhibitors contribute to additional effects in the form of delaying hunger, sensitizing cells to insulin, which decreases the intake of calories.

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Composition

Container size: 90 tabletsServing size: 1 tabletServings per container: 90
per 1 tabletamount%DV
Proprietary blend with Thermo-Rx® oraz Extend-Rx™ Technologies325 mg-
Ephedra Extract (leaves)
Senegalia Berlandieri Extract (leaves) [Yielding 200mg Phenylethylamine Alkaloids, Including Methylsynephrine, N-Methyl-B-Phenylethylamine, N,N Dimethylphenylethylamine and Phenylethylamine]
Citrus Aurantium 60% Extract (supplying 20 mg Synephrine alkaloids)
Theophylline Anhydrous
Cassia Nomame Extract (plant)
6,7 Dihydroxybergamottin (fruit)
Evodiamine
5-Methoxytryptamine HCl
Yohimbe 8% Extract (bark)
Proprietary Tri-Xanthine™ Blend375 mg-
Guayusa Extract
Green Tea Extract
Theobroma Cocoa Extract (standardized to 200mg Caffeine, 45mg EGCG, 25mg Theobromine, and 40mg Theophylline)

Other ingrednients

Dextrose, Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Stearic Acid, Magnesium Stearate, Sodium Starch Glycolate, Starch, Triacetin, Titanium Dioxide, FD&C Yellow #5, Silica, FD&C Yellow #6

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Proprietary blend

Information

Proprietary blend - is a complex of bioactive ingredients in the proportions, which are covered by the manufacturer's patent. According to the law in force in Poland, the components of the blend are known, and , by the place on the packaging, you can identify which components are in bigger amount (the components are listed in the decreasing order of amounts).
Proprietary blends are used in many food supplements, such as creatine stacks, no-boosters, fat burners and pro-testosterone supplements, improving libido.


 

Senegalia Berlandieri

Information

Senegalia Berlandieri is a source of numerous alkaloids, among which the most numerous are: N-methyl-N-phenylamine, tyramine and phenylethylamine. Similarly to Acacia Rigidula, Senegalia Berlandieri promotes the required growth of energy and mood improvement, which it owes to its influence on increasing the level of dopamine and adrenaline in the organism. Senegalia Berlandieri extract also intensifies lipolysis and stimulates metabolism.

Phenylethylamine derivatives (PEA) contained in the extract of this plant are responsible for the effect of good mood (they stimulate the secretion of serotonin and dopamine), cause positive attitude to life and increase the willingness to act.

Thanks to its properties stimulating the nervous system, optimizing well-being and intensifying lipolysis, the extract from Senegalia Berlandieri is the component of many extremely effective and strong pre-workout boosters, at the same time being an effective DMAA substitute.

Synephrine

Information

Synephrine is an organic compound from harvested on an industrial scale the fruit of bitter orange (Citrus aurantium). Citrus auratuim extract (extract of bitter orange) is widely used in the process of weight reduction, both among athletes, active individuals, as well as leading the so-called. "sedentary lifestyle". It is a source of synephrine and octopamine, which in combination with caffeine and polyphenols contained in green tea affect lipolysis, releasing fatty acids adipocytes, by causing increased energy expenditure, burning them in the sources of vital energy cells (mitochondria). It is popular on the banning of ephedra by WADA (dangerous for the body). Contraindication to use preparations against people with hypertension. In the sports supplementation is available in body mass reduction and sculpting programs, as a thermogenic, creatine stacks and nitrogen boosters ingredient.
Dosage: No standards unit consumption. In the supplementation - customarily - 10-30 mg


 

Theophylline

Information

Theophylline is a natural compound from the group of methylxanthines, which is currently obtained also in a synthetic way. In natural conditions, theophylline can be also found in i.a. tea leaves and cocoa beans.

It has anti-inflammatory and relaxing effect, therefore as a drug it finds application in the treatment of asthma. In case of theophylline - as an ingredient of dietary supplements - the mechanism based on inhibiting the activity of phosphodiesterase is the most important here - an enzyme responsible for cAMP breakdown. Theophylline, by being an inhibitor of this enzyme, contributes to the increase of intracellular concentration of cyclic AMP, at the same time increasing thermogenic and lipolytic processes and increasing the ability to concentrate as well as reducing the feeling of fatigue.

Therefore, theophylline demonstrates similar activity to caffeine, additionally positively influencing respiration and improving blood flow through kidneys. These properties makes theophylline a valuable ingredient of fat burners and pre-workout supplements.

Cassia Nomame

Information

Cassia Nomame – wild herbaceous plant, willingly used in traditional Chinese medicine. It demonstrates dehydrating and laxative properties and has been used in problems with constipations.  It was noticed that one of side-effects of its application is weight loss, therefore it started to be used as an element of weight loss supplements.

However, according to the current knowledge on this plant, its abilities to stimulate fatty tissue reduction do not result from its laxative properties. Cassia Nomame provides compounds which are natural inhibitors of lipase, therefore it limits the absorption of fat in the human organism.

There are also sources which indicate that Cassia Nomame may have thermogenic effect and may stimulate metabolic rate. It makes the extracts from this plant an ideal ingredient of fat burners.

Apart from this, the plant has pro-health properties. It may have anti-inflammatory effect, due to which it is recommended in the therapy of arthritis. Some sources also suggest positive influence of Cassia Nomame among people suffering from migraines.

Importantly, Cassia Nomame cannot be taken by pregnant and breast-feeding mothers and people below the age of 18.

Evodiamine

Information


Evodiamine is an alkaloid with thermogenic and stimulating effect, allowing for faster burning of lipids, with an action similar to capsaicin. Source of evodiamine is plant of the family Rutacea. In the sports supplementation, its thermogenic potential is used in the combination with caffeine and green tea, as part of enhancing body fat reduction, improveing the body composition and aesthetics. It is also used by people with low physical activity in the weight loss process. It is a component of stimulating supplements (boosters and pre-workout creatine stacks)

 

5-Methoxytryptamine

Information

5-Methoxytryptamine - a compound naturally occurring in the human organism. Enriched in one acetyl group, it creates a hormone melatonin and it is structurally similar to serotonin. It is also known as mexamine.

Biological activity of 5-metoxytryptamine should be considered due to its structural similarity to serotonin. It is an agonist of serotonin receptors 5-HT1, 5-HT2, 5-HT4, 5-HT6 and 5-HT7. Because of this, it has stimulating influence on the functioning of the organism and increases the level of cyclic adenosine monophosphate in cells. Thanks to this, it stimulates metabolism and increases the effectiveness of stimulating catecholamines. Because of this activity, it is used in fat burners in order to maximize the pace of weight loss.

Some source also suggest the ability of 5-methoxytryptamine to promote cognitive functions.

Green tea extract

Information

Green tea extract is a concentrate that contains biologically active compounds: polyphenols (e.g. catechin, in the form of EGCG - epigallocatechin gallate), having antioxidant properties and a small thermogenic potential, modifies the action of testosterone metabolites, DTH. Green tea extract is an ingredient of many sports supplements containing fat burners, having pro-health and vitaminizing effect; also for those with low physical activity as an antioxidant and slimming supplement. Available either as mono-preparations, ready drinks, and above all as an extract.
Dosage: 200-500 mg per day (depending of the content of other active bio-components).


 

Caffeine

Information

Caffeine (1,3,7-trimethylxanthine, 1-methylotheobromine) is a purine alkaloid occurring in the natural state in plants (Coffea arabica, Camelia sinensis, Paulinia cupana, Ilex paraguariensis), which acts as a natural pesticide, acting toxic to insects. Peculiar smell and taste also deters herbivores. Caffeine in the body inhibits the adenosine receptors in the brain, fighting fatigue and allowing for action activation. It has a beneficial effect on the metabolism of oxygen, which increases the exercise capacity (strength and endurance) and rapid post-workout recovery. In the sports supplementation, caffeine is used as a stimulant nervous system. It has the thermogenic potential and in combination with other substances (e.g. Polyphenols, both occurring in coffee beans, such as cocoa beans, tea leaves and mate) can effectively participate in the reduction of body fat. It is included in many dietary stimulants (creatine stacks, no-boosters, beverages). It is a component of fat burners. It is also in the form of mono-preparation supplements.
Dosage: 100-600 mg per day. Due to the long release of activity should not be used in the evening, before
sleep.


 

EGCG

Information


EGCG (epigallocatechin gallate) - a compound occurring naturally in the leaves of green tea and sage nutmeg. Powerful antioxidant resulting in removing free radicals out of your body. It has the thermogenic potential (enhanced when combined with other substances including caffeine, capsaicin, etc.), allowing a faster fat reduction. Affects preventively in the side effects of the glandular hypertrophy (prostate) and male pattern baldness. Recommended for those who are active physically and professionally, for the maintenance of body composition and body aesthetics. It is a component of fat burners, allowing for faster slimming.
Dosage: 50-500 mg per day.

 

Theobromine

Information


Theobromine (3,7-Dimethylxanthine) is a purine alkaloid, poorly soluble in water, present in cocoa beans, as well as the leaves of yerba mate, tea, coffee, cola and peanuts. It is a diuretic, lowers blood pressure and improves brain function (dilates the blood vessels of the brain). Also expands the blood vessels throughout the circulatory system, preventing atherosclerotic changes. Sometimes it is used in slimming diet. Combined with caffeine and polyphenols becomes thermogenic. In the sports supplementation formulations containing theobromine are used diuretics and fat burners. It is a component of thermogenics, pre-workout creatine stacks, as well as nitrogen boosters.

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