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The formulation promotes general health, has anti-inflammatory and antioxidant properties and may be used to prevent cancer, neurodegenerative diseases, metabolic disorders and prostate dysfunctions. Apigenin is believed to increase brain plasticity and that is why it will work also as a memory booster and cognitive enhancer.
Apigenin is a natural chemical compound from a group of flavonoids. It can be found in fruits and vegetables, such as grapefruit, orange, parsley, onion, and camomile, wheat germ and some spices. Apigenin is characterised by extremely high bioactivity and has strong anti-inflammatory, antibacterial and anti-free radical properties. It is currently being tested for its anti-cancer activity.
Apigenin sustains glucose balance and helps lower serum sugar levels. Consequently, it reduces the risk of developing type 2 diabetes. The mechanism of action of apigenin may involve the modulation of the activity of glucose transporters and has thus a beneficial impact on its metabolic rate.
Apigenin may also reduce the incidence of metabolic syndrome and insulin resistance. Studies on rodents have shown that long-term intake of apigenin does not only stabilise blood sugar levels but also helps lower levels of total cholesterol and triglycerides and sensitises tissues to insulin.
One of the factors that increases the likelihood of developing diabetes is excess body mass. Scientists have discovered that obesity and metabolic syndrome are both correlated with NAD+ levels. The lower NAD+ levels in the body, the higher risk of metabolic disorders. Studies have demonstrated that apigenin contributes to an increase in NAD+ concentrations and helps maintain normal body mass, even when a diet is rich in fats and should theoretically lead to the development of obesity.
Apigenin regulates the body’s inflammatory response and helps reduce chronic systemic inflammation. It affects most known inflammatory markers – inhibits the activity of NF-kβ and TNF-α, suppresses the release of prostaglandin E2 and cyclooxygenase-2, reduces the production of proinflammatory cytokines and stimulates the production of anti-inflammatory cytokines. In addition, it maintains balance between Th1 and Th2 lymphocytes.
Extensive studies on anti-cancer properties of apigenin are currently underway. Initially, it seems that this compound has enormous anticarcinogenic potential and its efficacy is the result of many mechanisms of action.
Apigenin may reduce the risk of prostate cancer in men. On one hand, it inhibits enzymes which induce the production of androgens. On the other hand, it blocks the activation of IKKα which is considered a key regulator of oncogenesis and critical factor in metastasis. Studies have demonstrated that inhibition of IKKα expression stops the cell cycle automatically and causes a reduction in the proliferation of prostate cancer cells.
Scientists have shown that apigenin targets also other types of cancer, including cells of breast, liver, lung and anal cancer and osteosarcomas. It inhibits the proliferation of pathological cells by promoting their apoptosis (programmed death), inducing autophagy and regulating the cell cycle. It may also reduce the motility of cancer cells and thus prevents their moving to other parts of the body.
Apigenin has one more important mechanism of action related to its anti-cancer properties which should be mentioned here. This substance stimulates strongly the immune system and regulates the body’s immune response. Owing to that, the body is strong enough to deal with mutations that underlie carcinogenesis.
One of more interesting, although less known, properties of apigenin is its ability to strengthen memory and speed up learning. Scientists investigating this phenomenon concluded that it is due to the formation of new nerve cells and strengthening of neuronal connections.
In vitro studies have shown that apigenin may influence the structures responsible for neuroplasticity. Human stem cells treated with apigenin transformed after 3 weeks into new neurons and soon formed strong and functional connections. The number of neurons and effective communication between them are key factors for normal brain function, memory consolidation and learning. Further studies have proven that apigenin may also modulate the activity of BDNF, a protein secreted by neurons. This helps also strengthen memory and cognitive functions.
To sum up, Swanson Apigenin is an interesting supplement which may be used for many purposes. Individuals at increased risk of diseases of affluence, such as cancer, type 2 diabetes, metabolic syndrome, may use it regularly as a preventive measure or to help treat these diseases. The formulation will be also a good choice for individuals who want to improve memory and speed up learning naturally.
Apigenin is a natural compound and that is why it is very safe. There are a couple of studies which indicate that it may have toxic effects at very high doses. Because of that, it is suggested to follow the manufacturer’s recommendations and take 1 capsule daily.
Apigenin may react with hormone replacement therapy medications which are taken by women during menopause. It is recommended that women on HRT should not take apigenin.
SWANSON is a well known company operating since 1969, which offers a wide selection of diet and nutritional supplements. Among their products are antioxidants, amino acid supplements, products improving immunity, probiotics, minerals and vitamins. At SWANSON you can also purchase of supplements enhancing your cardiovascular stamina, urinary, nervous and digestive systems. The offer includes products designed specifically for women or men, as well as supplements helping to loose weight.
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|per 1 capsule||amount||%DV|
|Apigenin (derived from grapefruit)||50 mg||*|
Microcrystalline cellulose (plant fiber), gelatin, may contain one or both of the following: magnesium stearate, silica.
Apigenin is an organic chemical compound belonging to flavones, isolated for the first time in 1914 from chamomile herb. It is commonly found in grapefruits, oranges, onions, parsley and in many popular spices, such as oregano, thyme, basil, coriander, and cloves.
Apigenin has a number of pro-health properties – it has been proven to show anti-inflammatory, anti-cancer, anti-diabetic and neuroprotective effects. It also seems to have the ability to stimulate neurogenesis in the adult brain.
Apigenin is used not only for pro-health purposes. It is also a valued element of sports supplementation. Researchers have shown that it acts as an inhibitor of CYP2C9 and CD38. Inhibition of their activity translates into an increase in the level of NAD + in the body, which helps to maintain normal body mass, positively affects the physical condition and slows down the aging process of the body. In addition, apigenin may inhibit the expression of the aromatase enzyme, thus contributing to an increase in testosterone levels.
Supplements most often contain Apigenin isolated from grapefruit; chamomile extracts, standardized for the content of apigenin (usually 1%), are less common. It is also available in the form of a mono-preparation and sometimes it can be found in the composition of preparations for athletes.
Dosage: no standards of unit consumption.
In case of apigenin derived from grapefruit, a dose of 50 mg per day is usually used, and in case of chamomile flower extracts (standardized to 1% of apigenin), the recommended dose is about 500 mg.
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