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HPN NAD3 is a unique supplement raising the level of reduced form of nicotinamide adenine dinucleotide (NAD+) and extinguishing activity of NLRP3 gene, which causes inflammations. Higher level of NAD+ is associated with a number of health benefits, including improvement of cognitive functions, better sleep, efficient energy metabolism and slowing down the ageing process.
Nicotinamide adenine dinucleotide is a coenzyme that participates in cellular respiration processes. It is responsible for electron transfer during various reactions which are involved in regulating oxidative stress and circadian rhythms, maintaining cellular efficiency or repairing DNA.
Apart from NAD+, there is also an inactive form NADH, which only supplies electrons to the mitochondrial respiratory chain and enables the production of adenosine triphosphate (ATP). Unfortunately, the amount of NAD+ decreases with age, which changes the reduced-inactive form ratio. This ratio has recently been evaluated as one of the health determinants, because, as it was mentioned before, NAD+ regulates the course of many reactions and slows down the aging process.
HPN NAD3™ Clinical Formula mixture contains:
Japanese horseradish (Wasabia japonica) - it is characterized by high content of isothiocyanins, which effectively prevent inflammations. These compounds have the ability to block many inflammation development pathways and decrease the level of some markers indicating the presence of inflammation.
Theacrine - purine alkaloid improving mood and level of motivation, often used in pre-workout supplements. Theacrine also has strong anti-inflammatory and analgesic properties, and additionally has antioxidant potential.
Niacin - is a strong stimulator of NAD+ production, and its insufficient level in the diet may contribute to the reduction of the NAD+ / NADH ratio. In addition, one of the niacin metabolites is featured by strong ability to reduce inflammation.
Improved mitochondrial activity
It is in mitochondria, where high-energy compounds such as ATP are produced. They are responsible for neutralizing free oxygen radicals, generating heat and repairing DNA. Appropriate NAD+ / NADH ratio ensures undisturbed functioning of mitochondria, which will result in a noticeable increase in energy levels during the day, improved sports performance and reduced fatigue.
Sirtuins are a group of proteins which play a key role in the ageing and cell death process. It has been extensively proven that increasing the level of NAD+ boosts sirtuins activity, which is related to the anti-ageing effect, that is, the slowing down of ageing processes. Sirtuins delay ageing at the cellular level, limiting protein degeneration, activating repair mechanisms, or regulating gene transcription and the process of apoptosis.
Extended life expectancy
Telomeres are located at the end of the DNA strand in chromosomes, and their task is to control the repair processes and replication of the DNA strand. With each copying process, the length of telomeres decreases until the cell dies. Length of telomeres is one of the determinants of life expectancy, because the longer the telomere, the longer the cell division and repair can last. NAD+ contributes to telomere extension, DNA strand repair and improved chromosome stability, which is one of the mechanisms responsible for extending the life expectancy.
To sum up, HPN NAD3 improves health and organism functioning at the cellular level. It effectively raises the level of NAD+ and suppresses inflammatory states in the body, keeping up mitochondrial efficiency and activating the ‘longevity genes’. The supplement significantly increases energy levels, improves cognitive functions and gets rid of excess free oxygen radicals.
You can take the supplement without food or drink.
The packaging is enough for a monthly therapy increasing NAD+ level in the organism.
It is perfect for people with worsened mood, chronic fatigue or low energy levels.
It can be one of the elements supporting the work of mitochondria, where it acts in synergy with L-carnitine, PQQ or coenzyme Q10.
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Microcrystalline cellulose, hypromellose (vegan capsule).
Vitamin B3 (vitamin PP, niacin, nicotinic acid, nicotinamide) is niacinamide niacin. It is used in interaction with vitamins B1, B2 and B6 in the synthesis of hormones during lactation. It provides proper functioning of the brain and nervous system. It is helpful in inflammatory conditions of the skin. Required for synthesis of sex hormone, estrogen, testosterone, cortisone, and insulin. It does not lose its properties in the manufacturing and storage. The source of acquiring vitamins PP are both products of animal origin (the lean meat, eggs, fish) and vegetable origin (dates, figs, hazelnuts, plums).
Dosage: 2-12 mg / day for children, 14 mg / day for women, 16 mg / day for men and 17-18 mg / day for pregnant or nursing women.
Copper - trace mineral that facilitates the introduction of iron into hemoglobin, allowing the correct functioning of antioxidant processes. It is an important component of enzymes that affect the processes of aerobic metabolism, carbohydrate metabolism and in the formation of collagen. With proper diet, do not use supplements containing copper, as an overdose can cause insomnia, hair loss. It occurs in foods such as legumes, offal, plums, seafood. Copper compounds must be used in a responsible way, because many of them have toxic properties.
Dosing: A sufficient amount of copper provides proper diet.
Wasabia (Vitamin C, vitamin B6, Mn, Mg, K, Ca, green tea, Japanese horseradish) is a rich source of ascorbic acid (vitamin C), vitamin B6 and several minerals (such as magnesium, manganese, potassium, calcium). It has anti-inflammatory, immunological properties, improves, in the operation of the other factors involved in the metabolism, tissue sensitivity to the action of the hormone insulin, affecting the overall improvement in health. It is believed that the longevity of the Japanese is closely linked with the consumption of wasabia (and green tea). Part of the nutritional supplement for people who are physically active, available at www.muscle-zone.pl
Dosage: the lack of strict standards of daily consumption, consumption according to individual needs.
Theacrine is a purine alkaloid which occurs naturally in the fruits of cupuaçu (Theobroma grandiflorum) and the leaves of Camellia assamica. It is structurally similar to caffeine but it has also additional ketone and methyl groups. It also energises, enhances focus and reduces drowsiness and fatigue. In contrary to caffeine, it has more lasting effects and rather does not affect blood pressure. Furthermore, it has been observed that the body develops tolerance to theacrine more slowly and that is why there is no need to increase its dosage to obtain the desired results.
Like caffeine, theacrine can bind to adenosine receptors without activating them. Nonetheless, its effects depend on the dosage. Its high doses block adenosine receptors whereas low doses have the opposite effects – they boost adenosine levels in the hippocampus and that is probably why they may reduce negative effects of excessive caffeine intake. In addition, theacrine modulates dopamine receptors. Their activation leads to higher motivation and enhanced cognitive skills. It is also believed to have analgesic and antioxidant effects.
In supplementation, theacrine is treated as a stimulant. It is used to reduce drowsiness and fatigue and boost mental performance. It is often combined with caffeine to enhance and prolong its effects and prevent the harmful consequences of excess caffeine.
Theacrine is most frequently found in pre-workout supplements and fat burners based on stimulants. Single-ingredient preparations with pure theacrine are also available on the market.
Dosage: No official guidelines.
The most common daily dosage is from 50 to 300 mg. Doses below 50 mg will have a relaxing effect and those around 300 mg a stimulating effect.
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