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|Servings: 60 caps.|
Doctor’s Best Benfotiamine + Alpha-Lipoic Acid is a dietary supplement which contains a combination of 150 mg of benfotiamine and 300 mg of alpha-lipoic acid. It aims at improvement in carbohydrate management and support for energy metabolism.
Benfotiamine – a derivative of vitamin B1, thiamine, and at the same time its provitamine, which means that it can be converted into vitamin B1 in the body system. It shows up to 5 times higher absorption in comparison to the basic forms of thiamine, so that it is a much more efficient source of the vitamin. It is a a fat-soluble hydrophobic substance. It is involved in the metabolism of carbohydrates, which is why it is often used by people struggling with problems with glycaemic management.
Alpha-lipoic acid (ALA) – structurally, it is a fatty acid. It is present in mitochondria, where it supports energy management. It contributes to the removal of harmful oxygen free radicals, which is why it is believed to shows anti-ageing properties. It is known for its positive influence on insulin sensitivity and benefits for glycaemic management.
Benefits for carbohydrate management
A stable level of glucose in blood is crucial for health; prolonged hyperglycaemia or significant fluctuations in glucose level can lead to severe consequences. One of them is excessive glycation of proteins and formation of so-called AGE (Advanced Glycaemic End products), which destroys the body system and leads to faster ageing.
Benfotiamine is effective in preventing negative results of hyperglycaemia, so that it is particularly useful in case of diabetes. It inhibits protein glycation and prevents neuropathy, which improves the comfort of life. It reduces also degeneration of small blood vessels, characteristic for diabetes, which improves blood circulation and allows for proper nutrition of all tissues.
Alpha-lipoic acid is known for the improvement of insulin sensitivity; it can reduce glucose level even if used on an ad hoc basis. This results from its activity promoting the use of glucose for energy purposes. Studies report a decline in glycosylated haemoglobin level, which indicates a reduction in glucose level in blood also on the long term basis. Together with befotiamine, it promotes the fight against diabetic neuropathy. There are also some indications about the ability to reduce appetite, which can reduce consumption of calories and carbohydrates, which in turn reduces the risk of diabetes, obesity and further complications.
Alpha-lipoic acid reduces oxidative stress in neurons, so that they can live longer. Another protective mechanism is keeping glutathione in cells, which is an important aspect of prevention of excitotoxic glutamate action. In turn, if our neurons are already damaged, ALA can accelerate their regeneration.
Benfotiamine can relieve chronic pain. Its influence on pain perception can be observed in case of pain of different origins; benfotiamine is often used in case of neuropathic pain. Its neuroprotective potential suggests that it can be a part of prevention of neurodegenerative diseases, especially in combination with ALA.
ALA can promote lipid metabolism, which is particularly beneficial for people who observe high level of triglycerides in blood. It seems also to be helpful in slimming. First of all, it improves insulin sensitivity, which results from AMPK stimulations, and reduces appetite, which at the same time reduces calorie supply and promotes using the calories present in the body system. It is worth to mention that an increase in AMPK is not related to the relationship between AMP and ATP.
Another advantage is increased uptake of glucose by muscle cells, which is particularly important for athletes. This mechanism is also supported by benfotiamine, as it improves glucose utilisation in skeletal muscles independently from the paths of AMPK activation and signalisation of insulin receptor.
Benfotiamine is also believed to be an antioxidant, especially in the cells of the immune system. It can also reduce inflammation, as it reduces the release of arachidonic acid and inhibits other proinflammatory factors. Moreover, it protects cardiomyocytes from the action of stressors, which has positive impact on the condition of the cardiovascular system.
To sum it all up, Best Benfotiamine + Alpha-Lipoic Acid is especially recommended for people who want to improve carbohydrate management and/or reduce the consequences of hyperglycaemia. It is also a perfect preventive measure against different diseases, especially neurodegenerative ones, has positive influence on the general condition of the body system and slows down ageing processes.
It is a quite universal product which can be used both for preventive and therapeutic purposes. As a preventive measure, it can protect from the diseases of the nervous system, diabetes, cardiovascular diseases and too fast body system ageing. In this case, the recommended dose is one capsule a day.
Such diseases as diabetes, neuropathy or neural damage demand a bit higher doses; it is recommended to take at least 2 capsules a day, divided into two portions.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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|per 1 capsule||amount||%DV|
|Alpha-Lipoic Acid||300 mg||-|
Modified cellulose (vegetarian capsule), silicon dioxide
Leucine is an essential amino acid, one of the three branched chain amino acids, ketogenic, its isomer is isoleucine. It affects the secretion of anabolic hormones (insulin, combined carbohydrates), acts on enzymes (mTOR) starting the process of muscle protein synthesis and controlling its course. Protein synthesis by leucine is affecting the development of bones, muscles and skin. It reduces the fat tissue. Without the availability of leucine, protein synthesis is impossible. It naturally occurs in animal products (such as eggs, meat, dairy and fish), plant origin, and as a post-training supplements, BCAA, EAA, no-boosters, creatine stacks, carbohydrate supplements. Ir is also in the form of mono-preparation supplements. It is one of the most important amino acids for the athlete's body, basically in every sports discipline.
Dosage: The demand is 5-10 g / 24h, dosage pre- and post-workout and in the morning after waking up.
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