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Doctor's Best Benfotiamine is a unique dietary supplement which contains vitamin B1 in a form of bio- and neuroactive benfotiamine. A single-capsule dose is perfectly suited to quickly feel the positive effects.
Benfotiamine – something more than vitamin B1
Benfotiamine is a modern form of thiamin. It is oil soluble, and thanks to that it crosses the lipid barrier of neurons and is very helpful in the treatment of clinical deficiencies linked with the complications in the nervous system. Moreover, the comparative studies confirm a five times higher concentration of vitamin B1 in the cells after oral dosing, in comparison to thiamin – its common form (popular in other vitamin preparations).
Benfotiamine has a wide range of clinical uses: in the prevention of metabolic diseases and diabetes. It effectively supplements the deficiency of vitamin B1, also in the central nervous system. It contributes to the reduction of diabetes-related complications: neuropathy, nephropathy and retinopathy. What is more, it can be also used to relieve acute pain and alcoholic neuropathy.
Vitamin B1 and its role in the body system
Vitamin B1 has basic functions in the energetic transformations of carbohydrates and keto acids in the process of cellular respiration, which is confirmed by numerous studies. It has been demonstrated that its levels among patients with diabetes is up to 75% lower than among healthy people.
The biologically active form of vitamin B1 is thiamine diphosphate (TDP – thiamine diphosphate), which is a coenzyme of very important multienzyme complexes.
Moreover, as thiamine triphosphate, it is involved in neural conduction and induction of nerve growth factor (NGF). At the same time, it phosphorates chloride channel in the nerve membrane and plays a role of its activator.
Benfotiamine in clinical practice
A clinical study (randomized, double-blind) has been conducted on 165 patients with diabetic polyneuropathy in diabetes type 2. Some of them were applied with benfotiamine supplementation in an amount of 600 mg per day for a period of 6 weeks. The results showed a significant therapeutic effect, in particular, the reduction of the pain intensity. However, another study suggests that this compound may have anticancer properties.
Benfotiamine / the glycation of proteins
Protein glycation is a non-enzymatic process of glucose attaching to free amino acids groups of proteins and, at the same time, it is a physiological process which determines proteins aging. These reactions are more common in hyperglycemia, diabetes complications in forms of retinopathy, nephropathy, polyneuropathy and atherosclerosis of the arteries of brain, heart, kidneys and legs.
Diabetic neuropathy means a poor prognosis and deteriorates the quality of life. As it has been demonstrated, benfotiamine aligns the disturbed metabolism in diabetes, which causes that hyperglycemia does not affect alternative metabolic pathways, such as hexose pathway, glycation, diacylglycerol pathway, as it activates the transketolase, which causes that the metabolites from the breakdown of glucose are consumed in the penthose cycle, preventing the creating of advanced products of AGE glycation.
To sum it all up, Doctor's Best Benfotiamine is a dietary supplement which is recommended for older people, suffering from fatigue, smokers and obese people with metabolic disorders. It is especially recommended for athletes and people who work physically.
Vitamin B1 in the best-available form. Deficiencies of this vitamin are very common. Few people know that drinking large amounts of tea and coffee causes it to leave the body quicker. Preferably, take 1-2 capsules per day. it's a water-soluble vitamin, so you can take it with or without food.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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Microcrystalline cellulose, modified cellulose (vegetarian capsule), silicon dioxide.
Leucine is an essential amino acid, one of the three branched chain amino acids, ketogenic, its isomer is isoleucine. It affects the secretion of anabolic hormones (insulin, combined carbohydrates), acts on enzymes (mTOR) starting the process of muscle protein synthesis and controlling its course. Protein synthesis by leucine is affecting the development of bones, muscles and skin. It reduces the fat tissue. Without the availability of leucine, protein synthesis is impossible. It naturally occurs in animal products (such as eggs, meat, dairy and fish), plant origin, and as a post-training supplements, BCAA, EAA, no-boosters, creatine stacks, carbohydrate supplements. Ir is also in the form of mono-preparation supplements. It is one of the most important amino acids for the athlete's body, basically in every sports discipline.
Dosage: The demand is 5-10 g / 24h, dosage pre- and post-workout and in the morning after waking up.
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