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Raw Series Sulbutiamine is a dietary supplement with 100% powdered sulbutiamine, a lipophylic form of vitamin B1 (thiamine). This form is characterised by good absorption and the ability to cross the blood-brain barrier and that is why it may increase effectively levels of thiamine compounds in the brain. The product is in a powder form which makes it easy to use.
Sulbutiamine is a compound composed of two thiamine molecules which are bound via an ester bond. Such chemical structure makes sulbutiamine a lipophylic compound (soluble in fats), unlike the hydrophilic thiamine.
Thiamine and its derivatives have an important role in cell metabolism. As cofactors of enzymes, they regulate many energy transformations and amino acid metabolism. Vitamin B1 optimises carbohydrate metabolism by stimulating transketolase activity and normalises the lipid profile. Thiamine deficiency is the cause of many neurodegenerative diseases whose progression may be halted by the proper dosage of vitamin B1. As a vitamin, thiamine is an exogenous substance – in order for the body to function properly, it must be supplied in adequate amounts.
Sulbutiamine is an active and effective derivative of vitamin B1. Studies showed that injecting the same doses of sulbutiamine and thiamine led in both cases to a rapid increase in blood thiamine levels. Sulbutiamine is converted into vitamin B1 during its biotransformation. Interestingly, a study on animals has shown higher potency of sulbutiamine in increasing blood levels of thiamine compounds than thiamine alone. Subsequently, while examining brain structures, higher levels of thiamine triphosphate were observed only in the group who was given sulbutiamine.
Lipophylic properties of sulbutiamine help it enter the cerebral circulation. Hydrophilic molecules have an electric charge. Because of that, it is difficult for them or they are not able to pass the blood-brain barrier. The situation is different in the case of lipophylic substances which may diffuse through the membrane or be transported and thus enter the cerebral circulation.
Sulbutiamine shows neuroprotective properties. A study has shown that sulbutiamine may protect nerve cells in the hippocampus when they are not supplied with glucose or oxygen, which are essential nutrients for neurons. In such conditions, neurotransmission is disrupted, thereby leading to cell dealth. There was a higher percentage of dead cells in the control group than in the treatment group in which cells were incubated in sulbutiamine solution.
Sulbutiamine supports cognitive functions. This compound is most commonly used for asthenia – chronic mental and physical fatigue. Studies on animals have shown that sulbutiamine affects dopaminergic, glutaminergic and cholinergic neurotransmission. It has been also demonstrated to improve memory.
Sulbutiamine may be helpful in erectile dysfuction. There have been several studies which show the effectiveness of sulbutiamine in treating psychological erectile dysfunction. Psychic impotence may be caused by, among others, chronic stress, complexes and depression. The efficacy of sulbutiamine has been assessed in studies by the International Index of Erectile Function (IIEEF).
To sum up, Raw Series Sulbutiamine is a dietary supplement recommended especially for physical and mental fatigue and diet poor in thiamine and to support cognitive functions, including memory and focus.
Sulbutiamine is a lipophylic substance. Because of that, it should be taken preferably with a fat-containing meal. The best results of supplementation can be achieved after short-term use of the product. Because of potential stimulant properties, it is suggested to take the product in the evening.
#RAW provide the highest quality ingredients, found in nature, sourced only from the most reputable suppliers and sold direct to the consumer.
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Sulbutiamine – a syntetic derivative of vitamin B1, characterised by much higher absorption. It can penetrate biological membranes and cross the blood-brain barrier. According to studies, it shows neuroprotective properties (improves cognitive functions, mainly creativity, motivation and memory) and has health-promoting effects.
Due to its ability to penetrate the brain, it may increase levels of thiamine (to which it is metabolised). This influences greatly the modulation of neurotransmitters (as reported by studies, it increases the amount of dopamine receptors in the brain and is an important cofactor in acetylcholine synthesis) and neurons. Its nootropic effect is connected with the stimulation of metabolism in the central nervous system.
According to some sources, sulbutiamine may be effective also in individuals with different states of anxiety and depression. It has probably the ability to boost confidence and reduce inhibitions in persons with depressive disorders.
Sulbutiamine may be used successfully by athletes. As stated by scientists, it helps increase the body’s endurance, reduce time needed for recovery and boost energy required for physical activity. It may probably speed up blood flow and increase oxygenation levels.
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