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JARROW Vitamin D3 is the highest-quality supplement, allowing to effectively complement deficiencies of vitamin D3 in the organism. It contains as much as 5000IU of cholecalciferol in each capsule, thanks to which it enables effective supplementation even in large deficiencies.
The high need of supplementation with vitamin D3, which has been discussed more and more often recently is not only the matter of temporary fashion. Natural pathway of the synthesis of this vitamin in our organism, induced by the activity of UV radiation, for the greater part of the year is insufficiently effective. It is mainly related to the geographical location of Europe and limited exposure of naked body to sunlight. Therefore, deficiency of vitamin D3 is a common phenomenon, which entails many health consequences.
Promotion of skeletal system endurance
Vitamin D3 is associated mainly with its influence on the osteoarticular system. It demonstrates positive activity on calcium balance and osteocyte maturation, thanks to which it positively influences mechanical endurance of bones. It is also important for the health of teeth (in this case, the ability of cholecalciferol to stimulate the immune response against tooth decay is also important). Vitamin D deficiency is indicated as a factor causing the development of osteoporosis.
Moreover, positive influence of vitamin D3 on the functions of joints was proven. Supplementation with this vitamin may be effective even in relation to pain reduction in the movement apparatus. It is related to the selective tissue ability of vitamin D to modulate metabolism of aromatase, transforming testosterone to estrogens. By stimulating its effectiveness in the tissues creating joints, it promotes their functionality.
Optimization of hormonal balance
Thanks to tissue selectivity of vitamin D3 in relation to aromatase P450, it does not stimulate negative effects of excessive activity of this enzyme, such as e.g. the promotion of carcinogenesis. Quite the contrary, supplementation with cholecalciferol demonstrates positive influence on hormonal balance. It allows to optimize the level of sex hormones, stimulating their proper effectiveness in the organism. Moreover, vitamin D may also increase the activity of testosterone by limiting the activity of sex hormone binding globulin SHGB to its biologically inactive form.
Stimulation of the immune system
Vitamin D also demonstrates considerable influence on the tissues of the immune system. It promotes their functionality, intensifying the immune response. It is especially effective in relation to bacteria, thanks to the ability to activate genes coding beta-defensin and cathelicidin, peptides with strong antibacterial effect. Thanks to the ability to inhibit the synthesis of cytokines, vitamin D also has anti-inflammatory properties.
Increased pace of muscle recovery
Supplementation with vitamin D3 also demonstrates positive influence on muscle tissue. It was proven that it increases the pace of muscle regeneration after intensive training sessions. In this way, supplementation is conducive to increasing sports results and faster achievement of goals.
Protection of neuronal tissues
Thanks to the ability to modulate the functions of calcium channels, present in nerve tissues, vitamin D3 demonstrates neuroprotective effect. Apart from this, supplementation with cholecalciferol is also conducive to positive mood and may be even effective in depression therapy. It positively influences sleep, promoting its quality. Some sources also indicate the application of vitamin D as potentially beneficial in the therapy of such disorders as Alzheimer’s or Parkinson’s diseases.
Decreased risk of hypertension
Vitamin D3 also plays a role of an inhibitor of renin expression in the organism, thanks to which it limits the activity of the renin–angiotensin–aldosterone system. Thanks to this, it prevents the development of hypertension and may also demonstrate therapeutic effect in people with hypertension.
To sum up, JARROW Vitamin D3 5000IU is a supplement which enables effective increase of vitamin D3 supply in a diet. Thanks to a wide spectrum of effects, it has important pro-health influence. It is especially active towards the functions of the movement apparatus, promoting both the functionality of the osteoarticular system as well as the muscle system, but other properties are also important: neuroprotective and immunomodulating properties and the effect optimizing hormonal balance.
The supplement provides as much as 5000IU of vitamin D in each capsule, therefore during its application, the level of a metabolite 25(OH)D in blood should be constantly monitored.
Vitamin D belongs to the group of vitamins soluble in fats, therefore the supplement should be taken with meals containing lipids.
Vitamin D and vitamin K work synergistically, therefore it is worth considering the application of the supplement containing vitamin K along with this preparation.
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Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
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