• Regulation of calcium and phosphorus management
• Support for immune system
• Rickets and osteoporosis prevention
• Positive effect on well-being
• Pleiotropic effect on organism
• Increased insulin sensitivity
• Proper bone mineralisation

Scitec Nutrition Vitamin D3 is a dietary supplement containing vitamin D3. Vitamin D3, also referred to as “the sunny vitamin”, is a commonly deficient nutrient essential for the normal functioning of the organism. One capsule contains 500 IU of vitamin D3.

Vitamin D3 (cholecalciferol) is a compound with steroid structure, one of fat-soluble vitamins. To some extent, it is synthesised in skin from provitamin D3, provided that the skin was exposed to UV-B radiation for a sufficient amount of time. As a result of sun radiation, the body produces vitamin D3, which is a precursor for active forms like calcidiol and calcitriol, synthesised in the liver and kidneys.

Receptors of the active forms of vitamin D3 are found in cells of nearly every organ in the organism, which says a lot about how wide the range of its activity is. The receptors, called VDR, are found in such structures as bone, brain, heart, or intestinal cells. VDRs are nuclear receptors that regulate the expression of about 200 genes.

Vitamin D3 determines normal phosphorus and calcium management. Phosphorus and calcium form crystals of hydroxyapatite, which constitutes almost 90% bone mass. Proper phosphorus and calcium management in the organism is, therefore, essential for normal bone mineralisation. Vitamin D3 regulates the level of those elements by, for example, increasing their absorption from the gut and the kidneys. Vitamin D3 deficiency in children leads to the development of rickets, and in adults – osteoporosis.

Vitamin D3 participates in all stages of osteoblast differentiation. Osteoblasts are bone-forming cells whose main function is the production of organic bone matrix, which is then mineralised. With the presence of vitamin D, osteoblasts synthesise the protein osteocalcin (OC), which takes part in the process of calcium binding in bones. Moreover, when an active form of vitamin D3 binds with its receptors in osteoblasts, some genes are activated that affect the differentiation of osteoclasts – cells responsible for breaking down bone tissue and, consequently, regulating the modelling of bones and affecting their optimal mechanical resistance.

Vitamin D3 supports the organism’s immunity. The result of vitamin D binding with its receptors found in neutrophils and B and T lymphocytes is inflammation reduction. Vitamin D helps monocytes to mature to the form macrophages, that is the pathogen-fighting cells. Vitamin D deficiency contributes to the body’s weakening and is connected with the development of autoimmune diseases. It has been demonstrated that vitamin D helps to reduce the inflammation that accompanies such conditions as RA and psoriasis.

Vitamin D3 helps to increase glutathione levels. Glutathione is a compound needed for the removal of many harmful chemical compounds from the organism. Its greatest concentration is found in the liver. As a powerful antioxidant, it exhibits neuro- and cardioprotective properties as well as reduces oxidative stress.

Vitamin D3 affects the normal functioning of the nervous system. The substance affects the down-regulation of channels for calcium ions, whose excessive inflow inside nerve cells causes excitotoxicity connected with too high glutamate levels. A correlation has been proven between vitamin D deficiencies and the risk of developing depression, sleep problems, and a low mood.

Vitamin D3 supports the cardiovascular system.Regular vitamin D3 supplementation helps to reduce the risk of a cardiac arrest. The activation of vitamin D receptors supports the synthesis of renin, a hormone that forms the RAA system, which is responsible for such processes as arterial blood pressure regulation. A correlation has been demonstrated between vitamin D3 deficiencies and the occurrence of arterial hypertension.

To sum up, Scitec Nutrition Vitamin D3 is a dietary supplement recommended for long-term regular supplementation, especially in the case of vitamin D3 deficiency. It ensures optimal mineralisation of teeth and bones, supports immunity, prevents the development of cardiovascular and nervous system diseases, and helps to combat low energy levels and fatigue.