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Avitale Vitamin K2 from D3 20 mcg 500 IU is a dietary supplement which contains natural vitamin D3 from lanolin, vitamin E and vitamin K2 as patented VitaMK7®, derived in fermentation of Bacillus Subtillis Natto bacteria and with efficacy proven by EFSA. A convenient bottle with an applicator allows you to dose the product precisely and makes it suitable for children.
Vitamin D3 (cholecalciferol) is a vitamin which functions as a prohormone. It may be synthesised from provitamin D in the dermis and epidermis. However, this process requires adequate exposure of the skin to UVB-radiation. Due to our current lifestyle, exposure to sun rays is insufficient, which is usually the cause of common vitamin D3 deficiency.
Vitamin D3 is critical to normal bone mineralisation by maintaining calcium-phosphate balance. Vitamin D3 is needed for optimal absorption of calcium which is an element that is an essential component of bones. What is more, by binding to its receptors (VDR), it stimulates the activity of osteoblasts, preventing the development of rickets and osteoporosis.
Vitamin D3 has neuro- and cardioprotective properties. By increasing levels of glutathione, a potent substance in the intracellular antioxidant system, vitamin D3 helps detoxify the body and protect it from harmful waste products of oxidation. This vitamin is also necessary for normal functioning of the cardiovascular system – it may reduce the incidence of hypertension.
Vitamin D3 boosts immunity and has anti-inflammatory properties. Vitamin D receptors are located in immune cells – neutrophils and T and B lymphocytes. Vitamin D3 is reported to be helpful in autoimmune diseases, among others, psoriasis.
According to clinical studies, vitamin K2 reduces the frequency of bone fractures. It is because it regulates osteocalcins and proteins critical to calcium transport to bones. In the event of vitamin K2 deficiency, elevated levels of calcium in the body caused by vitamin D3 may lead to the accumulation of this element in arterial walls. This may result in their calcification and consequently the development of cardiovascular diseases.
To sum up, Avitale Vitamin K2 with D3 20 mcg 500 IU is a dietary supplement recommended to maintain normal calcium balance and bone and teeth mineralisation, support the immune system, prevent cardiovascular diseases and promote general well-being.
The latest studies suggest that vitamin D3 has synergistic effects with vitamin K2. What is more, they improve bone mineral density better than supplements with vitamin D3 only.
For better absorption, take the product with a fat-containing meal.
Avitale® is a line of products made by the Polish pharmaceutical company MedicaLine, established in 2007. The fact that the preparations of this brand are of the highest quality is supported by the company’s specialisation in the production of hospital medications.
Dietary supplements Avitale® are available in the form of high-quality vitamin drops. The preparations have a “clean label”, which means that they contain no unnecessary additives. The bioactive forms of vitamins are suspended in organic, first cold-pressed olive oil and natural vitamin E. A bottle with an accurate dropper makes it possible to administer a precise dose of the product. The preparations are free of gluten, milk and soy.
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Organic extra virgin olive oil.
Vitamin K exists in the triad of vitamins: menaquinone (vitamin. K1), menadione (vitamin. K2) and menadione (vitamin. K3), soluble in fat. It is produced by bacteria in the human colon. Natural sources of vitamin. K are: eggs, kale, cauliflower, cabbage, meat, milk, lettuce, spinach, fish oil and liver. The synthetic form is administered to newborns, to reduce the sterility of the gastrointestinal tract. Used as a antihaemorrhagic, due to its participation in the process of prothrombin. Increases antibacterial and antifungal immunity. Prevents abundant bleeding during menstruation of women.
Vitamin K deficiency causes external bleeding and ecchymosis on skin, decreased prothrombin synthesis in the liver (especially while taking antibiotics and sulfanilamide).
Vitamin E (tocopherol) is a fat soluble. Due to its antioxidant action, it is a protection of other vitamins (e.g. Vitamins A). Protects the body against free radicals, strengthens the walls of blood vessels and its capacity, causing their dilation and dissolution of blood clots. With the reduction of coagulation, it is used as an antiatherogenic medicine, it allows for the proper course of pregnancy. In cooperation with selenium it slows the ageing process of cells, strengthening connective tissue. In the food it is present in whole-grain bread, sprout and grains, vegetable oils (soybean, sunflower), soya beans and sunflower seeds, vegetable fat and hen egg yolks. Also it is used in sports medicine in the form of nutrients and supplements.
Vitamin E deficiency reduces building of red blood cells, results in changes in muscle and disorders of pregnancies.
Dosage: for children, 0.5 mg / 1 kg of weight; for adults 10-30 mg per day.
D-alpha-tocopherol – a natural form of vitamin E which is indicated as the most optimum for supplementation. It helps correct effectively deficiencies of this compound which is extremely crucial for the human body.
Vitamin E is a very important bioactive substance found in many tissues and required for normal functioning of the body. Its deficiencies may be manifested by impaired cognitive abilities and vision, muscle weakness and infertility. It is involved in erythropoiesis and that is why its low intake may lead to anaemia.
In addition, vitamin E has an important role as an antioxidant in the human body. It has the ability to reduce the amount of free radicals, thereby decreasing negative oxidative stress.
During supplementation with d-alpha-tocopherol, we should remember that it belongs to fat-soluble compounds, along with vitamin A, D and K. Because of that, supplements with vitamin E should be taken with a fat-containing meal.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
Lanolin is obtained in the process of cleaning of raw sheep wool from the so-called wool fat, protecting it from getting wet and unbeneficial weather conditions.
Lanolin is commonly used for the production of ointments and creams with lubricating and softening effect, however, it also found application in the production of dietary supplements and more precisely vitamin D3.
In order to obtain vitamin D3 from lanolin, it undergoes cleaning and crystallization and then proper chemical processes, as a result of which 7-dehydrocholesterol is produced - a precursor of vitamin D3, the same which is produced in skin under the influence of UV radiation. 7-dehydrorocholesterol obtained from lanolin is then subjected to the above mentioned radiation, being transformed to vitamin D3.
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