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Now Foods Natural E-400 is a dietary supplement which is the combination of natural vitamin E (in the form of D-alpha tocopherol) and selenium. One capsule provides 400 IU of vitamin E and 100 mcg of selenium. Vitamin E is the main vitamin with antioxidant properties and demonstrates pharmacological synergism with selenium.
Vitamin E, i.e. tocopherol, owes its name to its positive influence on increasing fertility (tokos – birth, heros – bring). From the chemical point of view, it is a group of organic substances with the common two-ring skeleton. Many types of tocopherols have been discovered so far, but the highest activity is demonstrates by alpha-tocopherol. Vitamin E is one of four vitamins soluble in fats.
Vitamin E demonstrates strong antioxidant properties. In the organism it functions as an oxidation-reduction factor, taking part in moving a hydrogen atom from flavoproteins to cytochrome C. It stabilizes cell and lysosomal membranes. As the main antioxidant in the organism, vitamin E protects from the oxidation of polyunsaturated fatty acids, phospholipids and also low density cholesterol fraction (LDL). Oxidized LDL contribute to the creation of the so-called atheromatous plaque in artery walls, the effect of which may be the development of atherosclerosis.
The compounds of vitamin E slow down aging processes of the organism, due to their effectiveness in neutralizing free radicals. Moreover, vitamin E elasticizes blood vessels and decreases degeneration of erythrocytes, which improves oxygenation of cells of the organism and energy metabolism. By stabilizing cell membranes, it effectively protects neurons from the processes of degeneration and peroxidation. This type of neurodegenerative processes are intensified with age, the result of which may be i.a. decreased mental ability.
Selenium is a trace element, essential for the proper functioning of the human organism. The compounds containing selenium, especially enzymatic proteins, take part in many important metabolic pathways. In these enzymes, selenium atom constitutes the active center for redox reaction. In this way, selenium sweeps away reactive oxygen species (ROS) and reduces inflammation. As an element of the antioxidant system of the organism, selenium decreases the toxic effect of xenobiotics, primarily heavy metals. Selenium deficiency may result in the aggregation of the excessive amount of free radicals, which entails unbeneficial health consequences.
Selenium takes part in the transformations of thyroid hormones. It is the component of iodothyronine deiodinases, which disconnect iodine from thyroid hormones. The highest concentration of selenium in the organism is observed in the thyroid. It was proven that selenium deficiency considerably increases the risk of developing autoimmune diseases and hypothyroidism.
Selenium is the component of glutathione peroxidase (GPx), cooperating with vitamin E. Selenium appears here in the form of selenocysteine. Glutathione peroxidase constitutes a certain antioxidant barrier of the organism. Its function is catalyzing the reduction of the toxic hydrogen peroxide by glutathione. Vitamin E has a stabilizing effect on the activity of glutathione peroxidase and prevents the damages of mucous membranes made by free radicals. It also demonstrates synergistic anti-inflammatory properties with selenium.
Low level of selenium and glutathione peroxidase was observed in people with rheumatoid arthritis, eczema and psoriasis. Free radicals, pro-inflammatory prostaglandins and leukotrienes are the cause of the considerable part of tissue damage in rheumatoid arthritis. Therefore, selenium deficiency, by decreasing the level of glutathione peroxidase, especially important in the reduction of inflammation, intensifies this harmful effect. Studies confirmed the effectiveness of the supplementation with vitamin E and selenium in mitigating the symptoms of this ailment, but also in other sick people with inflammations.
To sum up, Now Foods Natural E-400 is the preparation containing the combination of substances, mutually strengthening their effects, which ensures optimal pharmacological effect. The product is recommended especially to people dealing with thyroid work disorders, autoimmune diseases, people who lead a stressful lifestyle, are prone to environmental pollution, regularly take medicines, in order to increase fertility in men and as prophylaxis in order to generally boost immunity and health of the organism.
Vitamin E and selenium not only demonstrate pharmacological synergism, but they also mutually improve their absorption from the digestive system, therefore combining them in one preparation is a beneficial solution.
People who regularly take drugs (e.g. contraceptives) may need more selenium.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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Softgel Capsule (gelatin, glycerin, water, carob), Soybean Oil, Beeswax and Soy Lecithin.
Vitamin E (tocopherol) is a fat soluble. Due to its antioxidant action, it is a protection of other vitamins (e.g. Vitamins A). Protects the body against free radicals, strengthens the walls of blood vessels and its capacity, causing their dilation and dissolution of blood clots. With the reduction of coagulation, it is used as an antiatherogenic medicine, it allows for the proper course of pregnancy. In cooperation with selenium it slows the ageing process of cells, strengthening connective tissue. In the food it is present in whole-grain bread, sprout and grains, vegetable oils (soybean, sunflower), soya beans and sunflower seeds, vegetable fat and hen egg yolks. Also it is used in sports medicine in the form of nutrients and supplements.
Vitamin E deficiency reduces building of red blood cells, results in changes in muscle and disorders of pregnancies.
Dosage: for children, 0.5 mg / 1 kg of weight; for adults 10-30 mg per day.
Selenium (element, chemical symbol Se, atomic no. 34, from chalcogenide, it is present in several allotropic forms). It is supplied the body with food in the form of seleno-amino acids (selenomethionine - gathering supplies, and selenocysteine – a component of glutathione peroxidase, deiodinase and seleno-proteins). Regulates the functioning of the thyroid gland. It affects the growth and development, including sexual development (by increasing production and sperm motility). It affects the flexibility of the tissue, removes some of the toxins from the body and destroys cancer cells and reduces the severity of menopause in women. Natural products containing selenium are seafood (sea fish, oysters, bladderwrack) and vegetable products (broccoli, onions, wheat germ, bran, tomatoes) and animal products (poultry, eggs). It is also included in the composition of vitamin-mineral and mineral supplements. Selenium supplementation is recommended as a dietary supplement of active people having diet poor in this element, and as a factor increasing the body's immunity.
Selenium deficiency increases the risk of developing cancer and heart disease. Symptoms of selenium deficiency are: cardiomyopathy, growth stoppage, disorders of detoxification processes which may lead to damage to the kidneys and liver.
An excess of selenium can lead to selenosis (the disease, the symptoms are: loss of hair, nail cracks, lesions).
daily demand of selenium for pregnant women 65 mcg; nursing mothers 75 mcg; men 7 mcg.
Mixed tocopherols - a method of complementing vitamin E, commonly used in supplementation, encompassing tocopherols and tocotrienols. The compounds from the group of vitamin E belong to the substances soluble in fats, therefore they should be taken with fats.
The main activity of vitamin E in the organism is its activity as antioxidant. It demonstrates the ability to neutralize free radicals and consequently to reduce oxidative stress. In this way, it positively influences the state of tissues of the organism. Supplementation with antioxidants is indicated as an effective method of delaying the signs of aging and it may demonstrate anticancer properties. Apart from this, supplementation with vitamin E, thanks to its antioxidant properties, positively influences the absorption of some other biologically active compounds.
Supplementation with vitamin E also demonstrates cardioprotective properties. Its proper concentration in blood prevents the pathological breakdown of erythrocytes, increases endurance of blood vessel walls and decreases the risk of developing atherosclerosis.
For maximal absorption and effectiveness, vitamin E should not be used with vitamin K and supplements containing iron.
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