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Vitamins from group B – is a package of substances soluble in water, which are essential for the proper work of the organism and need to be provided with food. They demonstrate a wide spectrum of effects, however, their most prominent role is fulfilled in regulating the functions of the nervous and cardiovascular system and energy metabolism. Apart from vitamin B12, they don’t have the ability to accumulate in the system, therefore they should be taken every day.
The supplement is distinguished by the presence of carefully selected, most active and safest forms of vitamins, such as P5P, methylfolate or methylcobalamin.
Vitamin B1 (thiamin) – helps to maintain proper psychological functions, plays a major role in the health of the circulatory system and energy metabolism. It is used in many forms in order to increase mental abilities and clear the mind.
Vitamin B2 (riboflavin-5′-phosphate) – effective form of riboflavin. It helps to maintain healthy skin and mucous membranes, influences the state of vision, helps to protect the organism against excessive oxidative stress. It may reduce the feeling of fatigue and contribute to the proper functioning of the nervous system.
Vitamin B3 (niacin and niacinamide) – it has incredibly positive influence on regulating lipid profile by lowering total cholesterol and improving the proportion of HDL and LDL fractions. It is also used in many psychological diseases, such as schizophrenia. It contributes to reducing the feeling of fatigue and weariness. It also influences the state of skin and mucous membranes.
Vitamin B5 (calcium pantothenate) – takes part in energy metabolism, especially in lipid metabolism as a coenzyme A and plays an important role in the process of the production of steroid hormones and vitamin D. It may reduce fatigue and improve mental ability.
Vitamin B6 (Pyridoxal 5-Phosphate,, P5P) – bioactive form of vitamin B6, the effect of which is 5 times stronger than traditional pyridoxine. It supports the process of homocysteine breakdown to cysteine, takes part in the production of red cells, contributes to the regeneration of hormonal activity, is a cofactor in many biochemical reactions, among others in neurotransmitter transformations.
Vitamin B7 (biotin) – it helps to maintain healthy skin and hair, is a popular component of supplements for women, it may also improve the state of mucous membranes. It is a coenzyme of carboxylases, takes part in the synthesis of fatty acids. It supports the health of the nervous system and maintaining proper psychological functions.
Vitamin B9 (5-Methyltetrahydrofolate, methylfolate, 5-MTHF) – a biologically active form of folate. It takes part in DNA synthesis, it is incredibly important during pregnancy in order to maintain proper fetus development. It takes part in producing blood and amino acid synthesis, it contributes to the breakdown of homocysteine to methionine, takes part in the process of cell division, supports the work of the nervous and immune systems.
Vitamin B12 (methylcobalamin) – an incredibly important factor for the health of the nervous system. It takes part in the production process of myelin sheaths and neurons, helps to maintain proper psychological functions and mental abilities. It takes part in the production of red cells and in the processes of cell division. It is a cofactor in the reaction of homocysteine conversion to methionine.
Choline – the compound from the group of betaines, which helps in the proper functioning of liver and takes part in fat metabolism. It intensifies homocysteine metabolism. It is a substrate for the production of acetylcholine neurotransmitter, which is responsible for memory, concentration and the ability of analytical thinking.
Folic acid trap
In food and supplements synthetic form of folic acid is commonly used - pteroylmonoglutamic acid. However, it turns out that it is not a healthy practice, since as Norwegian researchers proved in the research on a large sample of people, the supplementation with folic acid contributes to the considerable growth of the risk of cancer. The reason for this may be the commonness of the occurrence of gene MTHFR polymorphism, which codes the production of enzymes transforming folic acid in the active, methylated folate. Therefore, to circumvent the problem and avoid increasing the risk of carcinogenesis, it is recommended to take folate in a ready-made, methylated form, which can be found in the supplement made by the company Thorne.
The importance for the circulatory system
The supplement containing vitamins from the group B, especially in their active forms, may be helpful especially for those who fight with anemia and increased level of homocysteine, which is one of the most trustworthy risk markers of atherosclerosis development and heart attack.
Vitamins B for the health of brain
Proper supply of these vitamins is a key factor to maintain proper health of nervous system cells, efficient neurotransmitter metabolism and, as a result of this, proper well-being and physical condition. Supplementing the level of these vitamins may result in the reduced feeling of fatigue, better mood and more efficient brain work.
Thorne B-Complex is recommended to people with diagnosed deficits and those who complain about problems with memory, concentration, energy level and well-being. It is incredibly helpful in circulatory system diseases prophylaxis, especially in the case of high homocysteine concentration.
For health prophylaxis, even one capsule a day should be sufficient. Higher amounts may be used only for therapeutic reasons, especially with the aim of lowering excessive homocysteine levels and in the case of neurological problems. The dose of 3 capsules during the day should be appropriate even in the toughest cases.
The time of application has not been determined, however, prophylactic doses may be used all the time. Vitamins from the group B should be taken every day, as they are soluble in water and don’t have the ability to accumulate in the organism apart from one of them – vitamin B12.
Thorne Research is a company that since 1984 has been engaged in the production of the highest quality dietary supplements based on innovative recipes. Thorne Research in cooperation with other leaders on the market also produces pharmaceutical, therapeutic and medical preparations.
Thorne Research offers a wide range of products that are trusted worldwide by professionals in the healthcare sector. The activity of the products has been confirmed by numerous clinical tests. The company also has GMP, TGA and NSF certificates, which demonstrates compliance with relevant standards related to the production and safety of use.
The manufacturer constantly raises the bar and focuses on continuous development and improvement of the products by implementing the latest technological solutions and employing top-class specialists.
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|per 1 capsule||amount||%DV|
|Thiamin (as Thiamin HCl)||40 mg||3636%|
|Riboflavin (25 mg as Riboflavin and 5 mg as Riboflavin 5'-Phosphate Sodium)||30 mg||2143%|
|Niacin (as Niacinamide)||80 mg||500%|
|Vitamin B6 (85 mg as Pyridoxine HCl and 15 mg as Pyridoxal 5'-Phosphate)||100 mg||7143%|
|Folate (200 mcg as 5-Methyltetrahydrofolate from Methyltetrahydrofolic Acid, Glucosamine Salt)||334 mcg DFE||167%|
|Vitamin B12 (50 mcg as Adenosylcobalamin and 50 mcg as Methylcobalamin)||100 mcg||4000%|
|Pantothenic Acid (as Calcium Pantothenate)||45 mg||750%|
|Choline Citrate||14 mg||-|
Hypromellose capsule, Magnesium Citrate, Magnesium Laurate, Silicon Dioxide.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) is soluble in the liquid. It participates in the metabolism of proteins, fats and carbohydrates. By reducing the amount of fat in the blood do not enable deposition of the body. It helps the absorption of magnesium and vitamin B12 (cobalamin). It works on the muscle antispasmodic and anti-inflammatory pain in the joints. It acts anti. It provides efficient operation of the brain. It increases energy increasing vigor of a man. The demand for vitamin B6 increases during pregnancy and breast-feeding infants. The natural product is: yeast, eggs, wheat germ, meat (liver), wheat bran, nuts, peanuts peanuts, soybeans. There is a hypothesis that can be synthesized by intestinal bacteria.
Deficiency of vitamin B6 causes abnormal metabolism of proteins, decrease in lymphocytes in the blood, causes a feeling of lethargy and fatigue intensifies.
Dosage: 1.5-2.5 mg daily (increased demand during pregnancy and lactation).
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.
Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.
Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.
Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.
Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.
What is methylcobalamin?
Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.
The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.
Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.
Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Choline citrate is a combination of choline with a derivative of citric acid. It is a new form of choline which comprises about 51% of this substance. This means that 1 g of choline citrate corresponds to about 500 mg of choline. Because of that, it contains more choline than e.g. bitartrate.
Choline citrate does not only provide choline but also has one of acetyl groups necessary for the production of acetylcholine – the main neurotransmitter in the central nervous system that is extremely important for normal thought processes and supports cognitive functions.
Choline citrate is combined usually with a more sweet ingredient to neutralise its sour taste. It is available in the form of monopreparations and also as a component of multi-ingredient dietary supplements targeted at improving focus, motivation and psychomotor skills.
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