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|Servings: 1000mcg 100 caps.|
Jarrow Methyl Folate is a dietary supplement containing the latest 4th generation folate, Quatrefolic®, which made up of 5-methyltetra-hydrofolate and glucosamine salt. The 4th generation folates are characterised by high activity and absorption. One capsule provides 1,000 mcg of folates.
Due to the frequent occurrence of MTHFR gene mutation in the population, attention is often drawn to the so-called active folates. These are compounds, whose activity and absorption does not depend on mutations of that gene. Folates are classified by generations, the most active folate forms are the 3rd and the newest 4th generation. According to latest research, active folates have much higher bioavailability than popular folic acid. It has been shown that the 4th generation, which is glucosamine salt, is the fastest-absorbed and has better bioavailability than the 3rd generation folates.
Methyltetra-hydrofolate is a biologically active, methylated form of folate. Folates are involved in biochemical reactions, in which they play a role of coenzymes. They are a source of one-carbon residues, needed for the proper synthesis of DNA, proteins and myelin sheaths as well as for the transformations of amino acids. Folates are particularly needed in the cells which undergo intensive divisions, i.a. in bone marrow cells or fetal tissues.
Folates reduce homocysteine levels. Homocysteine is a sulphur amino acids, whose high blood level increases the risk of cardiovascular diseases, including coronary heart disease. It also promotes the development of mental disorders. Folates are necessary for remethylation of homocysteine to methionine, resulting in reducing homocysteine levels. Numerous studies demonstrate inverse correlation between the levels of folates and homocysteine in blood.
Folates support the balance in the nervous system. Too high homocysteine level promotes the development of mental disorders and neurodegenerative diseases. Impaired folate metabolism can activate neurotoxic and apoptotic processes. It is also suggested that folate deficiencies accelerate ageing of neurons and impair synthesis of particular neuromediators. Folate deficiencies are often observed in case of particular mental disorders, such as endogenous depression, psychosis and insomnia.
The complex folate sources support the proper pregnancy and child development. The proper folate supply is an essential factor in the prevention of congenital malformations, including serious neural tube defect. These defects are unfortunately still quite often. According to experts’ recommendations, during preconception and pregnancy, women should supplement folates in form of folic acid. You should not give up on using folic acid during pregnancy, but it is worth to supplement also an active folate, which will complement the folate levels faster and effectively support folic acid action.
Folates are necessary for the proper blood formation. Because of the important role in the DNA synthesis, folates and vitamin B12 are necessary for the proper production of erythroblast nuclei. Deficiency of these compounds results in production of abnormal megaloblasts, which are then transformed to enlarged and short-lived megalocytes instead of erythrocytes. This results in development of megaloblastic anaemia.
To sum it all up, Jarrow Methyl Folate is a dietary supplement which effectively complements folic acid deficiencies. The product is recommended to complement the diet poor in folates, for people with increased demand for folates, observing impaired methylation, higher homocysteine level as well as during pregnancy and preconception (in combination with folic acid).
It is worth to combine supplementation of folates and vitamin B12, which cooperates with folates in different biochemical processes. Moreover, vitamin B12 deficiency negatively affects folate retention in cells.
Folate deficiency is one of the most common avitaminosis. It can be induced by some drugs, including oral contraceptives, anti-epileptics and drugs reducing acidity of gastric juice (drugs from the group of proton-pump inhibitors).
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Cellulose and magnesium stearate (vegetable source). Capsule consists of gelatin.
Vitamin B9 (folic acid, folacin, vitamin M) is part of a complex of B vitamins soluble in water. It takes part in the production of red blood cells, in cooperation with vitamin B12, preventing anaemia progression, its molecules are involved in catalysis of hematopoietic processes. Together with vitamins B6 and B12 it helps in the treatment of hyperhomocysteinemia. It eliminates disturbances in the gastrointestinal tract. It affects the proper functioning of the immune system. Necessary during pregnancy, because its deficiency causes neural tube defects in the fetus. The natural ingredient of yeast, eggs, liver, green vegetables and it is synthesized in the gastrointestinal tract by intestinal bacteria.
Dosage: The daily requirement is 0.1-0.2 mg.
Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.
Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.
Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.
Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.
What is 5-methyltetrahydrofolate (5-MTHF)?
5-methyltetrahydrofolate (5-MTHF) is a methylated, biologically active form of folate. It is especially willingly used by people with folic acid metabolism disorders, especially by polymorphisms of the gene coding the production of methyltetrahydrofolate reductase. Using this form allows to skip narrow gorge created by this polymorphism and enjoy all effects induced by folates. It is also a good substitute for synthetic folic acid (pteroylmonoglutamic acid), which in clinical trials demonstrates the ability to increase the frequency of developing cancers.
Folates, also called vitamin B9 have a wide contribution to the development of the nervous system. They contribute to converting homocysteine to methionine and then to s-Adenosyl methionine, which is the main donor of methyl groups. Thanks to this, the condition of the circulatory system is increased, as the amount of pro-inflammatory homocysteine is decreased and the intensity of the production processes of creatine and neurotransmitter synthesis is higher, which is reflected in the reduction of fatigue and better psychological condition.
5-MTHF in mono-supplements and complex vitamin preparations may be found in the offer of muscle-zone.pl.
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).