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Hepatica, Affron® is a dietary supplement which contains the patented extract from hand conditioned saffron stigmata, standardised for the minimum content of 3.5% of lepticrosalides. These are a complex of bioactive substances which are responsible for the antidepressant, anxiolytic and procognitive properties of saffron.
The manufacturer guarantees the highest quality of the raw material and strict control at every production stage, starting from farming, through harvesting, to the ready extract. Thanks to that, the end-product standard is much higher than other supplements which contain saffron stigmata.
The supplement was designed for people who want to improve their mental well-being, increase energy level and resistance to stress in a natural and safe way. It effectively supports treatment of mild and advanced depression and anxiety; it some cases it can even replace synthetic antidepressants. It is also useful in case of sexual disorders, especially those resulting from the use of antidepressants (e.g. from the SSRI group). Saffron extracts are popular among women who want to get rid of bothersome PMS symptoms or reduce body weight.
Saffron (Crocus sativus) is a tuber, one of the most expensive spices in the world, valued for its taste and commonly used in alternative medicine. Numerous clinical studies have proven its anti-inflammatory, immunomodulating and antioxidant properties. In herbal medicine, saffron gained its popularity as an antidepressant and support for sexual health.
Saffron stigmata are used for therapeutic purposes. Each flower produces only three stigmata which are so brittle that they have to be harvested manually (hence such high prices of saffron). Despite their small size, saffron stigmata contain about 150 different biochemical compounds; the most important are so called lepticrosalides (crocin, crocetin and its esters, picrocrocin and safranal). The highest quality supplements are standardised for the content of these substances.
Saffron components have great potential in depression treatment. They affect the monoamines which are crucial for the well-being. It has been proven that crocin and safranal block the reuptake of serotonin, dopamine and norepinephrine. This results in good mood, motivation, energy and vitality.
Antidepressant mechanism of saffron action includes also the influence on the glutamatergic system. Crocetin shows affinity to NMDA receptor, and particularly to the site binding phencyclidine which is responsible for blocking the ionic channel of NMDA receptor. One of the hypotheses about depression pathophysiology says that compounds inhibiting glutamatergic transmission shows antidepressant properties. While using strong antagonists of NMDA receptor is subjects to the risk of side effects, the substances showing mild affinity to the NMDA receptor seem to be promising remedies to mild and medium depression.
Saffron extracts not only improve mood but also soothe the nerves and have anti-anxiety properties. The most important role is played by safranal which affects GABA-alpha receptor and modifies the benzodiazepine site of this receptor.
In clinical trials, researchers compared effectiveness of saffron extracts to effects obtained by using classic antidepressants, imipramine and fluoxetine. It was unambiguously demonstrated that the effects are equivalent, while saffron extracts are much better tolerated and do not cause side effects.
Advantages of saffron extracts include memory and cognitive functions improvement. In some countries, saffron is commonly used in the treatment of cognitive disorders associated with age or resulting from neurodegenerative diseases (e.g. Alzheimer’s disease). It is also effective in the prevention of such disorders.
Crocin isolated from saffron prevents aggregation of beta-amyloid, a protein which plays an important role in the pathogenesis of neurodegenerative diseases. In turn, safranal slightly reduces the activity of acetylcholinesterase. Thanks to that, the amounts of acetylcholine in the body system rise, which results in faster learning, increased ability to associate facts and better memory.
Improved sexual performance
In the traditional folk medicine, saffron is considered to be an aphrodisiac and spice improving fertility. It is surprisingly effective in people in whom sexual disorders are side effects of antidepressant drugs from the SSRI group. It does not change effectiveness of therapy and reduces the majority of dysfunctions, such as erection disorders and premature ejaculation in men and vaginal dryness in women. Moreover, in both sexes saffron restores interest in sex, positively affects excitement and improves satisfaction with sex.
Relieving symptoms of PMS
Large-scale research proved that saffron extracts effectively relieve bothersome symptoms of premenstrual syndrome (PMS), both mental (tearfulness, irritation, mood swings) and physical (swelling, breast tenderness, lower back pain, migraines). 76% of women using saffron confirmed that ailments disappeared (in the placebo group only 8%).
Body weight reduction
Saffron can be effectively used by people who want to reduce their body weight. It will be also useful if additional kilograms result from snacking. Positive influence of saffron on the nervous system, raising serotonin level and reduced anxiety facilitate appetite regulation and hunger reduction. It reduces also craving for snacks which often results from the need to improve mood, not from the real hunger.
In the one of the pilot studies, the group of 31 obese women used saffron extracts for 8 weeks, while 29 women of a similar age and body weight took placebo. During the research, they did not change their lifestyle nor diet. After 9-week therapy, the group using saffron observed significant body weight loss when compared to the placebo group. Also, the frequency of snacking dropped. Women claimed that they could easily manage the appetite and do feel craving for snacks.
To sum it all up, Affron® is an interesting proposition for people who struggle with low mood, anxiety or depression. It is also an optimal choice for those who decided on the traditional antidepressant therapy but they suffer from deterioration of sexual life quality, which is the most common side effects of antidepressants. An additional advantage of the preparation use is the improvement in memory and mental performance. It can also reduce additional kilograms.
The product can be an alternative to synthetic antidepressants in case of mild or medium depression. It is also helpful in case of sexual disorders.
The upper limit recommended in continuous supplementation amounts for 30 mg a day (1 capsule). Do not exceed the recommended daily dosage!
Hepatica is a young Polish producer dealing with the highest-class natural products. Its specialty is a range of plant preparations, devoid of unnecessary supporting substances. The quality of each of them results from proper selection of materials, high content of active substances, the dose adjusted to the needs and form of a given dietary supplement. The heart of the company is its founder, a renowned physiotherapist and co-founder of Nature Laboratory, SławekRasiński, who derives his inspiration and knowledge from around the World. Numerous travels and acquaintances with doctors and herbalists from all continents fruit, changing in dozens of unusual, effective and also often innovative preparations, on which a large board of analysis specialists work in the best prepared laboratories.
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|per 1 capsule||amount||%DV|
|Standardized Saffron Extract (Crocus sativus L.)||30 mg||*|
Microcrystalline cellulose, hydroxypropyl methylcellulose.
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