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Doctor's Best Best Stabilized R-Lipoic Acid is a dietary supplement in the form of capsules, with up to 100 mg of R-enantiomer of α-lipoic acid (R-ALA). The special formula, containing sodium salt of this acid (BioEnhanced® NA-RALA) guarantees the stability of the compound and its high bioavailability. Alpha-lipoic acid has a broad spectrum of health-promoting action, affecting the metabolism of carbohydrates, fighting oxidative stress and cleansing the body of toxic substances.
Alpha-lipoic acid is naturally synthesized in our body and serves many functions that are necessary for the proper functioning of the human body. It can be reduced to dihydrolipoic acid (DHLA) which shows similar physiological activity. The preparation has been designed with R-enantiomer exhibiting higher bioavailability than its synthetic counterpart. Both forms are soluble in both fat and water and that's why they're called "universal antioxidants".
The product has been enriched with the D-biotin isomer – the only active isomer of this vitamin which is bioavailable in the human body. This vitamin acts as a coenzyme in many enzymatic transformations of the body, including the impact on proper energy metabolism of carbohydrates and fatty acids. Its normal concentrations in the body help maintain a nice complexion and pretty nails and prevents hair loss.
Αlpha-lipoic acid acts as a cofactor in many biochemical reactions, e.g. is involved in the synthesis of enzymes necessary in the so-called Krebs cycle. It's responsible for the production of energy from energy substrates, including sugars provided with food in the mitochondria.
Many scientific researches describes also the action of R-ALA in improving the sensitivity of tissues to insulin. This can result in better glucose uptake by cells, improving its metabolism. It has been suggested also that it can activate the synthesis of glycogen in the muscles and enhance the oxidation of glucose. One of the explanations of this phenomenon is the inhibition of gluconeogenesis, i.e. a cycle of reactions resulting in the glucose production from amino acids contained for example in skeletal muscles.
Slowing down ageing processes
Undoubtedly, functioning of mitochondria ("energy generators") deteriorates with age, e.g. by decreasing mitochondrial enzyme activity and increasing oxidative stress. This hypothesis underlies the popular mitochondrial theory of ageing. Many researchers suggest that α-lipoic acid can slow these changes by assisting the functioning of enzymes and fighting reactive oxygen species. This can result in maintaining your health and good condition for years.
The fight against free radicals
Reactive oxygen species (ROS) are naturally produced in human cells in many metabolic processes and they act as a protection against different pathogens and as signal molecules. However, their excessive accumulation can lead to very dangerous health complications. Many scientific publications describe the positive impact of ALA and DHLA in combating ROS.
These compounds can probably fight oxidative stress in different ways. They can directly capture and neutralise free radicals, both in the aqueous and lipid phase. The researchers also prove that LA and DHLA has a regenerating effect on other intracellular antioxidant compounds, such as glutathione, vitamin C and E.
Environmental pollution from heavy metals causes that we deliver them to our body with food. Few people are aware of the negative action of such elements as lead, mercury or cadmium. Their excessive levels in various tissues of the body can contribute to the development of cancers, malformations in children, bone demineralization and damage to the nervous system.
A lot of research shows positive effects of α-lipoic acid in the prevention of metal poisoning. The researchers suggest different mechanisms of action of this compound. ALA may slow the absorption of arsenic from the gastrointestinal tract and promotes the excretion of mercury accumulated in the kidneys. It is also possible that its antioxidant properties minimise damage to the nerve cells caused by the action of mercury.
Hypertension is one of the most common diseases in our population which may lead to complications dangerous for our health and life. There is evidence that α-lipoic acid can reduce blood pressure and prevent pathological changes in the walls of blood vessels.
Support for the immune system
Scientific studies describe also positive effects of α-lipoic acid on the immune system. It has been suggested that this compound has the ability to regulate immune response by changing the distribution of T-lymphocytes and modulating the synthesis of pro-inflammatory substances.
To sum up, Doctor's Best Best Stabilized R-Lipoic Acid is a dietary supplement with multi-target, health-promoting action. It is particularly recommended for people doing heavy training, willing to mobilise their body for more efficient production of energy from carbohydrates and care for correct blood glucose levels. Moreover, it can be used for the overall improved condition of the body, also in the elderly. Importantly, it can be taken by vegans and vegetarians.
A very good combination of a-lipoic Acid with D-biotin. Pro-health effects of this product generally improve the condition of the body. Useful for people who want to improve insulin sensitivity. it's often recommended for athletes to increase aerobic capacity and increase muscle strength. The manufacturer talks about using one to two capsules a day, between meals. I know that there are studies suggesting that doses can be higher - up to 600 mg a day, and it's still considered to be completely safe. Athletes can combine it with for better results after a workout.
Alpha-lipoic acid is well-soluble both in water and in fats, therefore it does not need to be taken with fatty meals. Its absorption also does not require the presence of fatty acids in the intestines, therefore it may be taken on an empty stomach.
Dosing of ALA is often dependent on the goal that we want to achieve. For prophylactic purposes, 1 capsule a day is sufficient, while in case of diabetes and increased physical activity, it is worth increasing the dose to 2 or even 3 capsules a day.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
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|per 1 capsule||amount||%DV|
|R-Lipoic acid (from BioEnhanced® Na-RALA)||100 mg||-|
Modified cellulose (vegetarian capsule), rice powder, microcrystalline cellulose, magnesium stearate (vegetable source), silicon dioxide.
Biotin (vitamin H, co-enzyme R) is in a group of B vitamins, due to the presence of sulphur compounds it is involved in the synthesis of ascorbic acid (vitamin C). Also synthesized in the intestines. It enhances the production of hormones and regulates cholesterol levels. It reduces muscle pain. It prevents hair loss and graying of hair. It soothes the skin inflammations. No toxic effects. Often combined with other B group vitamins and vitamin A. The natural sources of biotin are: whole grain bread, yeast, eggs (yolk), milk, brown rice and cheese.
Daily demand: 100-300 mg per day
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