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Hydroxo B12 + Folinic Acid Hydroxo B12 + Folinic Acid

Seeking Health Hydroxo B12 with Folinic Acid is a supplement with two compounds which act synergistically in regulating methylation: vitamin B12 in the form of hydroxocobalamin and folinic acid. They support energy metabolism of every person with increased physical load and support also efficient functioning of the cardiovascular system.

Vitamin B12 – contained in the supplement as hydroxocobalamin. It ensures much higher absorption than the popular form cyanocobalamin. Studies indicate that hydroxocobalamin is the most bioavailable non-methylated form of vitamin B12. In the body, it functions as an active enzyme in numerous reactions affecting energy mechanisms.

Folic acid – also belongs to B vitamins, found under the number 9. It is vital to proper gene expression, regulates the development of neural tube in the foetus and neurons in adults. It is shown to affect significantly the mood and activity of neurotransmitters. More and more often high doses of folic acid are suggested as an alternative for strong psychiatric medications.

Folic acid vs. folinic acid
Although both names sound similar, and metabolically speaking, both acids are on the same pathway, there is a significant difference between them when it comes to supplementation.

Folinic acid, which is a common name for 5-formyltetrahydrofolate, is one of the two metabolically active forms of folic acid. For many years, folic acid was supplemented with the thought that it will easily enter the pathway of its transformations and convert to its bioactive derivatives. Meanwhile, more and more research suggests that the tendency for folic acid metabolism disorders is increasing. It is estimated that over half of society may have problems with synthesising the enzymes necessary for dealing with the crucial compound.

That is why it is much more beneficial to supplement the metabolically active forms of folic acid, that is folinic acid and 5-methyltetrahydrofolate. What is more, recent research demonstrates that supplementation of ordinary folic acid can be harmful for the organism, accelerate the development of cancer, and have a negative effect on foetal development.

Complex methylation support
Even though both vitamin B12 and folinic acid demonstrate many autonomous properties in the body, they have been used and selected in ratio maximising their synergistic action on improving methylation. It is a process comprising a range of reactions determining bioavaility of nutrients. Its disorders lead to impairment of all metabolic functions of the body, especially affecting energy mechanisms.

The role of vitamin B12 and folinic acid in homocysteine methylation
Cobalamin is a coenzyme of two reactions in the methylation pathway: the conversion of homocysteine into methionine and methylmalonyl-CoA intosuccinyl-CoA. The main task of the supplement is to improve the first one of these reactions. The formula provides the body with hydroxocobalamin, easily converted into the methylated vitamin B12 which is an active enzyme stimulating the production of  H4-folate from 5-methyl-H4-folate. 5-methyl-H4-folate (otherwise known as levomefolic acid) is a biologically active form of folic acid. Consequently, the formula supports comprehensively this phase of methylation.

The impact of methylation on metabolic homeostasis
The conversion of homocysteine has a significant role in cellular metabolism. Its disorders lead to impairment of the whole methylation process which entails disorders in other regulatory mechanisms of the body. It affects especially body energy balance because methylation products are intermediate substrates in the Krebs cycle – the basic energy mechanism of the human body.

Hyperhomocysteinaemia and the health of the cardiovascular system.
Disorders of homocysteine methylation will also cause its elevated concentration in the blood where it degenerates the blood vessel bed. Hyperhomocysteinaemia is associated with damages to endothelium of blood vessels. Because of that, it is identified as the primary cause of developing an atherosclerotic plaque.

To sum up, Hydroxo B12 with Folinic Acid is a complex support for the basic reaction in the methylation process. It ensures efficient functioning of body energy balance and healthy cardiovascular system. The supplementation with this formula should be considered by hard-training athletes as well as office workers – studies demostrate that mental stressors show the same ability to impair methylation as physical effort.

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Hydroxo B12 + Folinic Acid Hydroxo B12 + Folinic Acid 60 lozenges
Seeking Health
22.92 $

Hydroxo B12 + Folinic Acid 60 lozenges

Servings: 60 lozenges
1-2
Location:
EU Stock
Availability:
NONE
Working days
from the dispatch
Minimum expiration date:
2020-04
For free shipping is missing: 14.00 $
22.92 $With VAT

From 3 units only 22.46 $ /Units. -2%

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Description
  • Complex of the most bioavailable vitamin B12 and folinic acid
  • Syngergistic effects for complex methylation support
  • Promotes metabolism at the cellular level
  • Provides enzymes for many reactions in the body
  • Prevents atherosclerotic plaque formation
  • Improves body energy mechanisms

Seeking Health Hydroxo B12 with Folinic Acid is a supplement with two compounds which act synergistically in regulating methylation: vitamin B12 in the form of hydroxocobalamin and folinic acid. They support energy metabolism of every person with increased physical load and support also efficient functioning of the cardiovascular system.

Vitamin B12 – contained in the supplement as hydroxocobalamin. It ensures much higher absorption than the popular form cyanocobalamin. Studies indicate that hydroxocobalamin is the most bioavailable non-methylated form of vitamin B12. In the body, it functions as an active enzyme in numerous reactions affecting energy mechanisms.

Folic acid – also belongs to B vitamins, found under the number 9. It is vital to proper gene expression, regulates the development of neural tube in the foetus and neurons in adults. It is shown to affect significantly the mood and activity of neurotransmitters. More and more often high doses of folic acid are suggested as an alternative for strong psychiatric medications.

Folic acid vs. folinic acid
Although both names sound similar, and metabolically speaking, both acids are on the same pathway, there is a significant difference between them when it comes to supplementation.

Folinic acid, which is a common name for 5-formyltetrahydrofolate, is one of the two metabolically active forms of folic acid. For many years, folic acid was supplemented with the thought that it will easily enter the pathway of its transformations and convert to its bioactive derivatives. Meanwhile, more and more research suggests that the tendency for folic acid metabolism disorders is increasing. It is estimated that over half of society may have problems with synthesising the enzymes necessary for dealing with the crucial compound.

That is why it is much more beneficial to supplement the metabolically active forms of folic acid, that is folinic acid and 5-methyltetrahydrofolate. What is more, recent research demonstrates that supplementation of ordinary folic acid can be harmful for the organism, accelerate the development of cancer, and have a negative effect on foetal development.

Complex methylation support
Even though both vitamin B12 and folinic acid demonstrate many autonomous properties in the body, they have been used and selected in ratio maximising their synergistic action on improving methylation. It is a process comprising a range of reactions determining bioavaility of nutrients. Its disorders lead to impairment of all metabolic functions of the body, especially affecting energy mechanisms.

The role of vitamin B12 and folinic acid in homocysteine methylation
Cobalamin is a coenzyme of two reactions in the methylation pathway: the conversion of homocysteine into methionine and methylmalonyl-CoA intosuccinyl-CoA. The main task of the supplement is to improve the first one of these reactions. The formula provides the body with hydroxocobalamin, easily converted into the methylated vitamin B12 which is an active enzyme stimulating the production of  H4-folate from 5-methyl-H4-folate. 5-methyl-H4-folate (otherwise known as levomefolic acid) is a biologically active form of folic acid. Consequently, the formula supports comprehensively this phase of methylation.

The impact of methylation on metabolic homeostasis
The conversion of homocysteine has a significant role in cellular metabolism. Its disorders lead to impairment of the whole methylation process which entails disorders in other regulatory mechanisms of the body. It affects especially body energy balance because methylation products are intermediate substrates in the Krebs cycle – the basic energy mechanism of the human body.

Hyperhomocysteinaemia and the health of the cardiovascular system.
Disorders of homocysteine methylation will also cause its elevated concentration in the blood where it degenerates the blood vessel bed. Hyperhomocysteinaemia is associated with damages to endothelium of blood vessels. Because of that, it is identified as the primary cause of developing an atherosclerotic plaque.

To sum up, Hydroxo B12 with Folinic Acid is a complex support for the basic reaction in the methylation process. It ensures efficient functioning of body energy balance and healthy cardiovascular system. The supplementation with this formula should be considered by hard-training athletes as well as office workers – studies demostrate that mental stressors show the same ability to impair methylation as physical effort.

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Composition

Container size: 60 vegetarian lozengesServing size: 1 vegetarian lozengeServings per container: 60
per 1 lozengeamount%DV
Folinic Acid800 µg200%
Vitamin B12 (as Hydroxycobalamin)1000 µg41,667%

Other ingrednients

Xylitol, ascorbyl palmitate, silica, and natural cherry flavor.

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Folinic acid

Information

Folinic acid - 5-formyltetrahydrofolate, a biologically active form of folic acid. Its supplementation is recommended especially to people with methylation dysfunctions, as it is essential for the transformation of folic acid to the active folate. Taking into consideration the increasing tendency to disorders in this respect, folates are more and more often recommended as the basic, preferred forms of supplementation with folic acid.

Supplementation with these folates is especially recommended to women who are planning pregnancy or are pregnant. Folic acid in the biologically active form is responsible for regulating the formation of neural tube in the fetus and is conducive to its proper development.

In adults, folates are conducive to optimal methylation processes. It takes part in transforming homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. In this way, it positively influences psyche, as the effectiveness of this process is conducive to the production of S-adenosyl methionine with considerable influence on maintaining proper emotional states.

Some sources also indicate the protective influence of folates on the development of cancers. This information, however, is not fully unambiguous. The present state of knowledge suggests that since the optimal supply of folates really decreases the risk of cancer development, its supplementation in excessively high doses may demonstrate the reverse effect.

 

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