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Seeking Health Hydroxo B12 with Folinic Acid is a supplement with two compounds which act synergistically in regulating methylation: vitamin B12 in the form of hydroxocobalamin and folinic acid. They support energy metabolism of every person with increased physical load and support also efficient functioning of the cardiovascular system.
Vitamin B12 – contained in the supplement as hydroxocobalamin. It ensures much higher absorption than the popular form cyanocobalamin. Studies indicate that hydroxocobalamin is the most bioavailable non-methylated form of vitamin B12. In the body, it functions as an active enzyme in numerous reactions affecting energy mechanisms.
Folic acid – also belongs to B vitamins, found under the number 9. It is vital to proper gene expression, regulates the development of neural tube in the foetus and neurons in adults. It is shown to affect significantly the mood and activity of neurotransmitters. More and more often high doses of folic acid are suggested as an alternative for strong psychiatric medications.
Folic acid vs. folinic acid
Although both names sound similar, and metabolically speaking, both acids are on the same pathway, there is a significant difference between them when it comes to supplementation.
Folinic acid, which is a common name for 5-formyltetrahydrofolate, is one of the two metabolically active forms of folic acid. For many years, folic acid was supplemented with the thought that it will easily enter the pathway of its transformations and convert to its bioactive derivatives. Meanwhile, more and more research suggests that the tendency for folic acid metabolism disorders is increasing. It is estimated that over half of society may have problems with synthesising the enzymes necessary for dealing with the crucial compound.
That is why it is much more beneficial to supplement the metabolically active forms of folic acid, that is folinic acid and 5-methyltetrahydrofolate. What is more, recent research demonstrates that supplementation of ordinary folic acid can be harmful for the organism, accelerate the development of cancer, and have a negative effect on foetal development.
Complex methylation support
Even though both vitamin B12 and folinic acid demonstrate many autonomous properties in the body, they have been used and selected in ratio maximising their synergistic action on improving methylation. It is a process comprising a range of reactions determining bioavaility of nutrients. Its disorders lead to impairment of all metabolic functions of the body, especially affecting energy mechanisms.
The role of vitamin B12 and folinic acid in homocysteine methylation
Cobalamin is a coenzyme of two reactions in the methylation pathway: the conversion of homocysteine into methionine and methylmalonyl-CoA intosuccinyl-CoA. The main task of the supplement is to improve the first one of these reactions. The formula provides the body with hydroxocobalamin, easily converted into the methylated vitamin B12 which is an active enzyme stimulating the production of H4-folate from 5-methyl-H4-folate. 5-methyl-H4-folate (otherwise known as levomefolic acid) is a biologically active form of folic acid. Consequently, the formula supports comprehensively this phase of methylation.
The impact of methylation on metabolic homeostasis
The conversion of homocysteine has a significant role in cellular metabolism. Its disorders lead to impairment of the whole methylation process which entails disorders in other regulatory mechanisms of the body. It affects especially body energy balance because methylation products are intermediate substrates in the Krebs cycle – the basic energy mechanism of the human body.
Hyperhomocysteinaemia and the health of the cardiovascular system.
Disorders of homocysteine methylation will also cause its elevated concentration in the blood where it degenerates the blood vessel bed. Hyperhomocysteinaemia is associated with damages to endothelium of blood vessels. Because of that, it is identified as the primary cause of developing an atherosclerotic plaque.
To sum up, Hydroxo B12 with Folinic Acid is a complex support for the basic reaction in the methylation process. It ensures efficient functioning of body energy balance and healthy cardiovascular system. The supplementation with this formula should be considered by hard-training athletes as well as office workers – studies demostrate that mental stressors show the same ability to impair methylation as physical effort.
The product is a perfect methylation support for individuals lacking MTHFR gene mutation. If we observe a considerable increase in blood vitamin B12 levels and no changes/increase in homocysteine levels, it is recommended to stop using the product and choose a supplement with methylcobalamin and folates.
The product is also not recommended to women planning to have a child or in pregnancy. It is suggested to take folates in this case.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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Xylitol, ascorbyl palmitate, silica, and natural cherry flavor.
Folinic acid - 5-formyltetrahydrofolate, a biologically active form of folic acid. Its supplementation is recommended especially to people with methylation dysfunctions, as it is essential for the transformation of folic acid to the active folate. Taking into consideration the increasing tendency to disorders in this respect, folates are more and more often recommended as the basic, preferred forms of supplementation with folic acid.
Supplementation with these folates is especially recommended to women who are planning pregnancy or are pregnant. Folic acid in the biologically active form is responsible for regulating the formation of neural tube in the fetus and is conducive to its proper development.
In adults, folates are conducive to optimal methylation processes. It takes part in transforming homocysteine to methionine, thanks to which it demonstrates positive influence on the health of the cardiovascular system. In this way, it positively influences psyche, as the effectiveness of this process is conducive to the production of S-adenosyl methionine with considerable influence on maintaining proper emotional states.
Some sources also indicate the protective influence of folates on the development of cancers. This information, however, is not fully unambiguous. The present state of knowledge suggests that since the optimal supply of folates really decreases the risk of cancer development, its supplementation in excessively high doses may demonstrate the reverse effect.
Calcium (element chem. symbol Ca, atomic no. 20, the group of alkaline earth metals) is the basic building substance of bones and teeth, in which stored is 99% of the element, in the form of hydroxylapatite. When building bones and teeth, phosphorus is very important in the right proportion. It is a base-forming element and activator of many enzymes (ATPase) necessary to release the energy of ATP. It has a significant effect on blood clotting and regulates blood pressure and neuromuscular conductivity. Thanks to the reduced permeability of cell membranes, it soothes the symptoms of food allergies. Calcium is actively involved in the metabolism of iron interacts with vitamins A, C and D and phosphorus, magnesium. Natural source of calcium are animal products (dairy products, sardines, salmon, sprats eaten with bones) and plant products (nuts, soybeans, sunflower seeds). Absorption takes place in the small intestine (less in the colon), it has an effect on the level of lactose, insoluble fibre, organic acids, alkalinity (low pH). The best absorption have organic compounds (lactates, amino acid chelates etc.). Obstructing the absorption of calcium is caused by: phytic acid and oxalic acid as well as excess fat. Scientific studies have confirmed that the combination of calcium, magnesium, boron and vitamin D in dose 3 mg / 24h effectively prevent osteoporosis. Supplements on the market are both mono-preparation supplements (enriched with vitamin D3) and multi-component supplements, available at www.muscle-zone.pl.
Calcium deficiency disorders manifested in the construction of the bones (osteoporosis) and iron metabolism. The symptoms are: rickets, cramps and muscle tremor, osteoporosis.
Excess resulting from an overdose of calcium supplements containing vitamin D3 for children and adults overdose of calcium (hypercalcemia). Symptoms of hypercalcemia are: lack of appetite, vomiting and constipation.
The dosage administered in various publications are inconsistent: 800 - 1000 mg / 24 h (100 - 500 mg / 24h)
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
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