In the last batches of Apollo's Hegemony products, another glue was used for lids under the caps. The glue is weaker than previously used, this is why the lid often stays inside the cap when unscrewing the bottle. This does not affect the quality of products because during storage the lid adheres to the bottle and protects its contents.

• The standardised extract – 95% of curcuminoids
• High bioavailability thanks to piperine content
• Proven antioxidant and anti-inflammatory properties
• Prevention of cancers and nervous system diseases
• Supports mental functions and shows neuroprotective properties
• Protection of the cardiovascular system
• Positive influence on the bile duct functions

Apollo’s Hegemony Curcumin 95 + Piperine is a natural dietary supplement which contains the highly bioavailable turmeric extract, standardised for the 95% content of curcuminoids, with addition of piperine (95% black pepper extract) which increases its bioavailability. The product shows a wide range of health-promoting properties which base mainly on its antioxidant, anti-inflammatory and anticancer effects.

Curcumin is a yellow dye isolated from turmeric rhizomes (Curcuma longa), also known as Indian saffron. For ages, turmeric has been used in the traditional Far East medicine, not only because of its dyeing properties, but also due to its wide therapeutic effects, mainly anticancer, anti-inflammatory, antibacterial and antioxidant properties.

Anticancer properties of curcumin
Curcumin shows anticancer and chemoprotective properties. The substance affects modulation of gene expression whose disorders can affect cancer development.

It is fluorescent in the UV light. Such property allows for localising curcumin within a cell. In cancer cells, the fluorescence of curcumin was higher than in case of normal cells, which indicates its anticancer properties. What is interesting, despite the fact that curcumin increases sensitivity of cancer cells to ionising radiation, it has protective influence in case of healthy cells. It is associated with its antioxidant properties; as it scavanges free radicals, it reduces damage to DNA of healthy cells which are at risk of irradiation.

It is known that prolonged inflammation can contribute to cancer, and curcumin affects also the activity of enzymes responsible for its development – cyclooxygenase 1 responsible for the proper synthesis of prostaglandins and cyclooxygenase 2 activated by mitogens, oncogenes and carcinogenesis promotors.

It has been proven that curcumin affects particular lines of cancer cells which results in its support in case of i.a. leukaemia, ovarian cancer, lung cancer, breast cancer and cancers of the urogenital and nervous systems.

Antioxidant activity of curcumin
Curcumin is effective in neutralising O₂^-– and H₂O₂ as well as protects from oxidative damage to lipids and proteins. The substance stimulates release of antioxidant enzymes: SOD (superoxide dismutase), GPx (glutathione peroxidase), glutathione S-transferase and catalase. Thanks to its antioxidant properties, curcumin counteracts results of low prostacyclin PGI2 level, which is a factor responsible for relaxation of blood vessels, reduction in blood pressure and inhibition of blood platelets aggregation.

Influence of curcumin on the efficient cardiovascular system
There are more and more scientific studies which suggest positive influence of curcumin on the cardiovascular system. It has been observed that curcumin counteracts disorders of endothelium caused by homocysteine as well as reduces the production of superoxide anion radical whose synthesis is stimulated by this amino acid, which is why it reduces the risk of cardiovascular diseases. Moreover, it is an inhibitor of NF-κB, a nuclear transcription factor, whose increased activity induces inflammations and can cause atherosclerosis.

It is also suggested that curcumin has positive influence in case of cardiotoxicity of anticancer therapy. Because of its strong anti-inflammatory and antibacterial properties, curcumin can be a promising protection against heart damage resulting from chemotherapy.

Curcumin as a neuroprotective agent
Curcumin supports production of chaperones which counteract protein misfolding and protein aggregation, support the treatment of Alzheimer’s and Parkinson’s diseases as well as protect from memory loss associated with age.

Curcumin reduces cognitive disorders, oxidative stress and beta-amyloid accumulation whose deposits are present in the patients with Alzheimer’s disease.

It has been demonstrated that the substance can be involved in reducing nervous system damage resulting from the effects of metal ions which participate in oxidation reduction reactions and affect the growth of reactive oxygen species.

Curcumin and the digestive system
Curcumin has positive influence on the bile duct functions. Because of its spasmolytic properties, it stimulates smooth muscles of bile ducts, increases bile secretion and facilitates its flow. Moreover, it helps to keep the proper contractility of gallbladder, which is why it not only counteracts cholestasis and formation of gallstones, but also contributes to their dissolution. Moreover, it shows anti-inflammatory and bactericidal properties.

To sum it all up, Curcumin 95 + Piperine is a dietary supplement which increases immunity, reduces inflammations and protects the nervous system. Curcumin is a promising substance which can be safe and effective as a support in the treatment of i.a. arthritis, atherosclerosis, cancers, asthma and neurodegenerative disorders.