Serotonin regulates many brain func tions and behaviors. Such disorders as attention deficit, hyperactivity, bipolar disease, schizophrenia or impulsive behaviors are connected to the improper serotonin level.
Vitamin D and Omega-3 fatty acids supplementation demonstrates a beneficial effects in all the above mentioned disorders.
In the two-part study, the researchers from California checked the role of Omega-3 fatty acids and vitamin D in the serotonin synthesis and drew the following collusions:
- EPA supports serotonin release from neurons by lowering the number of inflammatory compounds connected to prostaglandins E2 (inflammation block serotonin release).
- DHA increases the liquidity of cell membranes in the brain, allowing serotonin to reach receptors easier.
- Vitamin D – regulates tryptophan conversion to serotonin.
The combination of Omega-3 fatty acids and vitamin D protects from the consequences related to non-optimal serotonin levels.
Mechanism of Vitamin D and Omega-3 fatty acids operations on serotonin level. Source: https://www.semanticscholar.org/paper/Vitamin-D-and-the-omega-3-fatty-acids-control-and-Patrick-Ames/b4aef4cf5865d279e58b39430e7069e251f27577
Vitamin D and Omega-3 fatty acids supplementation may support prevention of brain dysfunctions related to non-optimal serotonin levels, as well as contribute to the modulation of existing dysfunctions.
Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior. Patrick RP, Ames BN. FASEB J. 2015 Jun;29(6):2207-22. doi: 10.1096/fj.14-268342. Epub 2015 Feb 24.