Dietary supplements Supplementation Supplementation during dieting Weight Loss

How does Yohimbine HCl work?

Yohimbine is mainly used as an aid in reducing body fat. Many of us struggle with this drawback, it is not a simple problem to solve, so additional support is always useful. Currently, there are many substances on the market that work better or worse supporting weight reduction. Often, however, they act selectively or adversely affect other health issues. Does yohimbine belong to such compounds? It turns out that it does not, and besides the effective and effective support of fat burning, it also supports the multi-directional general system of the body.

To begin with

Yohimbine is a relatively new measure on the supplementation market, and it already takes a large percentage of it. It is a naturally occurring alkaloid, obtained from the bark of Yohimbe, or plants from the Rauwolfia family.

    What are the most important reasons for its ever-growing popularity?

    Effectiveness in fat burning

    Its basic mechanism is multi-directional facilitation of fat burning by:

    -Superacting signaling molecules (inactivate alpha-2-adrenergic receptors, which in turn allows to maintain higher concentration of cAMP in the body)

    -Adjusting the level of neurotransmitter release (affinity for alpha-2-c-adrenergic receptors)

    - Enhanced adrenaline (adrenaline activates beta-2-adrenergic receptors responsible for increasing cAMP levels)

    It also intensifies ketogenesis, which is especially significant for people running a high-fat diet. The overall effect of helping to reduce body fat is even more pronounced when combined with physical exercise.

    The action of yohimbine is not limited to direct action on metabolism. It also works indirectly, in other systems of the body.

    - acts as an inhibitor against the appetite (in studies, the intake of calories has decreased by up to 30%!)

    - regulates the blood level (drastic sugar level jumps, not only can affect large fluctuations in appetite, but also affect the whole body negatively)

    Relaxant effect of increasing concentrations of yohimbine in rabbit (panel a, closed symbols, n=8 in six separate experiments) and human (panel b, open symbols, n=6 in four separate experiments) corpora cavernosa pre-contracted with ET-1 (0.1 mM, circles) and phenylephrine (Phe, 100 mM, squares)

    Yohimbine is considered most effective at the end of reduction. Why? The sensitivity of this advice is included in the order in which fat is burned in the body, more precisely in the fact that in the last phase of weight loss, the areas of the most stubborn fat are remaining(and worst of all, these are the areas we most often want to "slim down" to make the muscles more visible), it is mainly about the chest and around the waist - especially the commonly known six pack on the stomach. Yohimbine "starts" burning fat from these areas just through the aforementioned mechanism of interaction with adrenergic channels.

    But wait, that's more!

    Limiting yohimbine only to interventional use, however, is harmful to its potential. Often, other significant benefits of its use are often overlooked. So what else is known about its use?

    We know, among other things, that it improves male sexual performance with an efficiency of up to 70%! (this is again the effect of alpha-2-adrenergic receptor inhibition). This effectiveness is so significant that yohimbine is clinically recommended as the first measure to support erectile dysfunction in exchange for drugs based on PDE5 inhibition. What's more, the research also indicates that it can reduce the negative effects of sex drive, caused by other drugs, without the need for testosterone-based steroid therapy.

    What else? Improved cognitive abilities! Yohimbine tested in research, increased the efficiency of solving arithmetic tasks. It reduces the cerebral pressure (within the brain) by up to 30%! Initially, it is also recognized that yohimbine may be helpful in therapies aimed at eliminating phobias (in the study it demonstrated effectiveness in the therapy against claustrophobia).

    Sounds too good? Maybe everything is balanced out by really bad side effects?

    Nope, nothing like that.

    Yohimbine is an intense study in terms of side effects, especially the most common, occurring in similar measures (elevated pressure, worse mood, nausea and the like).

    Pressure problems? At moderate doses (0.2 mg / kg), the cerebral pressure mentioned above is lacking, and even better.

    Feeling worse, nausea? Several studies are mentioned here. However, in supplementary explanations, it’s noted that this is often due to the effect of incorrect labeling of the active substance content on the label. It’s therefore worth choosing products from a reputable manufacturer.

    In the absence of health anomalies, studies indicate that toxic effects start within a single dose of 5000 mg. How big is the dose? Considering that in a typical capsule there are 3 to 5 milligrams of yohimbine, it’s about 10 packages of the product. Eaten at once.

    More of Yohimbine

    n addition to the yohimbine itself, it’s worth noting under which form it appears in the product. Often, in cheaper products, "yohimbine" is actually in the form of the root of the tree, Yohimbe. What's the difference? In standardization.

    Keep in mind that the whole root of Yohimbe is not yohimbine. It’s standardized for the content of alkaloids (usually around 2%), but the content of alkaloids is not yohimbine, but the alkaloid compounds. Most often the content of yohimbine is not even distinguished from them. Result? We don’t know how much of actual yohimbine we’re taking.

    For the above reason, it’s always better to choose yohimbine in the form of hydrochloride (most often referred to as Yohimbine HCl). This form shows the greatest efficiency in the delivery of the active substance, currently used on the market.


    Yohimbine is a very universal means of supporting general vitality. Not only does it work phenomenally in the process of reducing body fat, but it also improves sexuality (especially in men). It improves blood pressure in the most important area of life (brain), which requires special prevention. For this has minimal side effects.

    However, it should be remembered that yohimbine is the most effective in the form of hydrochloride, and that attention should be paid to the quality of the manufacturer to avoid distortions in the content of the active substance in the product, which may negatively affect the impression of supplementation.


    About author

    Cara Marshall

    Cara Marshall

    Dietetic or self-called "Kitchen-magician". The only things which I would get on the desert island are Pan and canola frying oil!

    Also, I have a Bachelor degree in chemistry, so I like to write about some chemical magic here and there.

    Hope that you will stick with my articles, and let me guide you in that strange world of circles and lines!

    › All posts

    Add Comment

    Click here to comment