This is a simple and extremely useful tool (a shipping cost progressive bar) that allows you to control the distance that separates from the next shipping discount threshold.
This is a simple and extremely useful tool (a shipping cost progressive bar) that allows you to control the distance that separates from free delivery.
Confirm or change your preferred country of delivery, language or currency. If you do this when logged in, your preferences will be remembered on your MZAccount. You can change them at any time by clicking the arrow at the top of the page.
Your location affects the final order price. It may vary depending on the amount of VAT rate applicable at your current location.
default stock for current location
From 3 units only: 32.94 € / Units. -2%
Doctor’s Best Calm is a dietary supplement containing 25 mg of a patented extract Zembrin® of the plant Sceletium tortuosum per capsule. It is a natural agent that helps to improve the mood and reduce mental stress while enhancing cognitive functions.
Sceletium tortuosum (Kanna) – an African plant traditionally used because of its psychoactive properties. It gained popularity as an agent used before stressful events, such as a hunt, when it was good to reduce stress and tension to be able to focus better on tracking prey. The traditional way of using it was chewing and swallowing with saliva; these days, extracts in capsules are used the most frequently. It has been known for hundreds of years, and its activity has been confirmed by numerous scientific tests, thanks to which the plant is gaining popularity again.
Serotonin – the happy hormone
Serotonin is usually associated with happiness. The neurotransmitter is responsible for the feeling of accomplishment, blissful joy and calm. Its deficiency is common for mental disorders, such as depression, anxiety, or social phobia. No wonder then that everyone strives to achieve its high levels.
One of the alkaloids contained in Sceletium tortuosum – mesembrine, exhibits affinity with the serotonin transporter SERT. Blocking the transporter results in less efficient uptake of unused serotonin back to the presynaptic neuron, thanks to which it gains greater concentration in the synapse and its effects are experienced more strongly because more of its molecules activate postsynaptic receptors. A similar mechanism is used in the most commonly used antidepressant drugs of the group of selective serotonin reuptake inhibitors (SSRI); however, this product is a completely natural alternative.
In stressful moments, we feel anxious, which can distort some functions of our bodies – hands starts shaking and thoughts racing, that way reducing the ability to focus on a chosen object or task. Such moments increase the activity of the part of the brain called the amygdala. It is one of the parts responsible for processing emotions.
As scientists report, Sceletium tortuosum inhibits the activity of the amygdala in those moments, thanks to which anxiety is less troublesome, and the mood stabilises. Thanks to that, in stressful situations we have better control of our bodies, our reaction time decreases and the ability to concentrate increases.
Kanna is also known for selective phosphodiesterase-4 (PDE-4) inhibition, thanks to which it increases cAMP levels in cells, just like artichoke extracts or a pharmaceutical rolipram. Increased cAMP in neurons practically helps to improve cognition, long-term memory, reduce inflammations, and protect the nervous system. The mechanism improves the functioning of the brain in a safe way, being beneficial for health, unlike frequently overused stimulants.
The procognitive properties of the extract were successfully checked with various tests before putting it to use. Better test results also stem from reduced anxiety and calm, as they make it easier to focus on a task at hand when we are not distracted by fear and stress.
Herb with complex activity
Both of the main mechanisms, that is serotonin reuptake inhibition and PDE-4 inhibition, complement each other, preventing each other’s potential disadvantages and reinforcing the positive effects. Serotonin reuptake inhibitors can lead to PDE-4 overexpression, so inhibiting the enzyme is strongly advised. Thanks to that, you can experience purely serotonin-based mood improvement without the things that often accompany it, that is laziness and weaker concentration, which make normal functioning more difficult.
Blocking PDE-4 alone, on the other hand, can lead to nausea, which is prevented by its interaction with the serotonin transporter. Thanks to that, the final effect is a unique combination of an improved mood with increased cognitive functions without the need to combine many agents, but only with the help of one plant extract.
To sum up, Doctor’s Best Calm with Zembrin® is recommended particularly for people who struggle with stress and anxiety but do not want to take pharmacological drugs or allow the drop of cognitive functions, which often accompany psychoactive drugs. It is a fantastic way to reduce the somatic symptoms in various stressful situations.
Take 1 capsule a day.
Physician-founded in 1990, Doctor’s Best is a science-based nutritional supplement company, offering more than 200 products, made primarily with branded ingredients that are thoroughly researched, manufactured to the highest quality standards, and rigorously tested every step of the way—from raw materials to finished product. We use only cGMP-certified manufacturing facilities. Doctor’s Best is committed to transparency through education and communication and strives to be crystal clear in what we offer, why and how we offer it.
Latest on blog
Alzheimer’s disease is nowadays one of the most common neurodegenerative diseases. It results in loss of nerve cells in the brain, leading to memory...
The Paleo diet aims to imitate as closely as possible the diet of the Paleolithic man. Paleo diet – we eat lean meat and fishPaleo diet – eggs, seeds...
As a medicinal plant, Psyllium has been known since ancient times (both in Europe and China). For years they have also been used in natural medicine. Due to their...
Donuts are known almost all over the world and depending on the region they may differ in filling (or lack thereof) and how they are called. Although they were...
Vitamin E is actually not a single, specific substance, but rather a group of chemical compounds. The demand for it depends on age and gender. Young children need...