The best nootropic agents of 2019

Nootropics are still one of the most exciting and fastest-growing scientific disciplines of discovery, which with each year develops its potential to optimize the human brain and body.

Below is a list of the best nootropics of 2019!


Nootropic eugeroic, which improves mood and cognitive functions and promotes alertness. Adrafinil is a truly unique stimulant that temporarily reduces fatigue without causing excessive activity. Originally developed for the treatment of sleep disorders, its effectiveness as a stimulant [1] and its proven nootropic benefits [2] make it more and more popular among students, shift workers and other people who want to improve their vigilance by working at the top your cognitive abilities.

Unlike amphetamine, caffeine and other traditional stimulants that act by enhancing psychomotor activity, adrafinil acts on specific parts of the brain [3] and selectively enhances the availability of many important substances in the brain. Adrafinil works more gradually, provides "smoother" energy and exhausts the action more gently than other stimulants, eliminating a large part of euphoria or "blackout" and the subsequent strike of fatigue typical of amphetamine.

Adrafinil is metabolized in the liver and processed into the active metabolite Modafinil, which works in the hypothalamus and amygdala in order to increase the availability of hypocretin, histamine, glutamate, dopamine and other brain substances associated with alertness, excitement and cognitive functions. Decades of research have shown that adrafinil is a safe, well-tolerated agent and there is a minimal risk of addiction in its case [4] if it is taken in moderate doses for short periods of time.

Modafinil is currently a separate drug on the market and is available on prescription in the US, Canada and most other countries. Adrafinil is still an unregulated drug and is sold without a prescription as a nootropic or dietary supplement.

If the maximization of both energy reserves and cognitive abilities is important to you, adrafinil is a nootrope in which you should invest in 2019.

Adrafinil - chemical structure
Adrafinil - chemical structure

Caffeine + L-Theanine

This combination is a perfect example of the old adage that "the whole is more than the sum of the individual elements" caffeine and L-theanine are popular, well-known substances that separately provide a moderate flow of cognitive capabilities. However, when they are combined, they constitute a non-nuclear power that increases energy levels and alertness, while reducing anxiety and increasing resistance to stress[5].

Smart Caps from Apollo Hegemony is a combination of caffeine, theanine and theacrine in optimal proportion
Smart Caps from Apollo Hegemony is a combination of caffeine, theanine and theacrine in optimal proportion

Caffeine and L-theanine are tea ingredients and are undoubtedly the main reasons why tea is at the very beginning of world lists of the most popular drinks, such as coffee or soda, and the tea itself combines caffeine with the calming and relaxing properties of L- theanine. When taken in the form of tea, caffeine and L-theanine combination is a mild and pleasant stimulant, but when used in high doses as a nootropic substance, it is an effective modulator of the brain [6], which adds energy, improves alertness and mood, and raises a feeling of peace and good being.

This combination also works great because of the synergy of its components. Caffeine, the most commonly consumed psychoactive agent in the world, is a stimulant of the central nervous system that increases energy metabolism in the brain and alertness, but it can cause anxiety and jitter. L-theanine is an amino acid that increases the level of GABA, a substance in the brain that has a pronounced calming and relaxing effect. Studies show that both substances taken together bring cognitive benefits [7], which will not be provided by any of the components separately.

Therapeutic doses of this powerful combination usually start with 50 mg of caffeine and 100 mg of L-theanine, which explains why drinking tea only does not have the same effect as caffeine and L-theanine in the form of a supplement. The content of both ingredients in a tea cup varies greatly depending on the type of tea and the method of brewing, and consuming enough high-quality tea to deliver L-theanine in psychoactive doses would be a time-consuming, costly and uncertain way to gain cognitive benefits.

Fortunately, caffeine and L-theanine are also available in capsules that deliver the right doses in the right proportions. This mix is ​​safe, effective, well tolerated and considered a good addition to most nootropes and a great introduction to the world of nootropics. In addition, it does not cost a lot and is widely available.

Hericium erinaceus

Can mushrooms improve our mood? Are they able to prevent the deterioration of cognitive functions, relieve anxiety and depression? Both modern research and the age-old traditional medical knowledge of the hedgehog suggests that the answer is yes.

Lion's Mane or Hericium Erinaceus are an ancient and venerable edible fungus that is now used in Asian cuisine and has been an important element of traditional Chinese medicine for the treatment of various diseases for centuries. But this mushroom is more than a delicious dish or an interesting relic of the past; recent clinical trials suggest that the Hericium has significant neuroprotective properties and is effective in the treatment of mild cognitive impairment [1].

Studies show that the Hericium reduces neurodegenerative diseases and promotes neuronal regeneration [2], which makes it a valuable supplement for nerve damage and increases the likelihood of treating neurodegenerative diseases such as Alzheimer's or Parkinson's disease. This is because the rootstocks stimulate the production of nerve growth factor (NGF), molecules that are known to provoke spontaneous repair of damaged neurons.

Hericium also improves the mood, which is beneficial in the treatment of depression and anxiety. Although the exact mechanism of action is not fully understood, it is believed that it is separate from the production of NFG.

Hericium is available in many forms at an affordable price, from pills to powder. If you want to improve your mood and cognitive abilities, and at the same time protect your brain, you can become one of many users who have discovered a new interest in this very old nootropic.

Lion's Mane (Hericium Erinaceus)
Lion's Mane (Hericium Erinaceus)


Coluracetam is a less well-known member of the nootropic racetam family, a type of "smart drugs" that works to a large extent by increasing the

Brain Fuel V2 from Apollos Hegemony is supplement containing Coluracetam, with another innovative nootropic substance called Sunifiram.
Brain Fuel V2 from Apollos Hegemony is supplement containing Coluracetam, with another innovative nootropic substance called Sunifiram.

availability of the "neurotransmitter of learning", acetylcholine. It is a derivative of piracetam, but unlike other racetames that consume the supply of choline in the brain at the time of increasing cognitive ability, coluracteram works more directly, by raising the amount of choline available to work for the brain.

Coluracetam also showed improved choline absorption in the brain, effectively improving choline synthesis. Sufficient choline for conversion to acetylcholine is essential for cognitive function, and animal studies have shown that a single dose of coluracetam improved learning impairment [3] in brains that were exposed to neurotoxins. Found images for the brainfuel-v2 query

Research on coluracetam is still ongoing, but it already has great potential as a long-lasting improver of cognitive functions [4], in the treatment of depressive disorders, neurodegenerative diseases and even as protection of brain health. Currently, its nootropic possibilities have not been very well documented in research, but many users report that it has a positive effect on many cognitive skills, from memory to learning skills, and there is anecdotal support for imagining that coluracetam improves mood, reduces anxiety and promotes feeling of peace.

Although coluracetam is a fairly new discovery and much remains to be investigated in terms of its effects and mechanisms of action, it is generally considered a safe and well tolerated agent if used in responsibly moderate doses. It is a widely available nootropic or dietary supplement at very affordable prices.

If you're looking for something new and innovative that you would like to add to your nootropic supplementation, coluracetam may be what you need.

Tags: adrafinil, caffeine, coluracetam, Hericium erinaceus, l-theanine, nootropic, nootropics, racetam, racetams, supplements, theanine

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