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Life Extension Mitochondrial Basics with PQQ is a dietary supplement which contains three active ingredients: L-taurine, R-lipoic acid and PQQ, which combined in a single capsule provide an ideal support for mitochondria.
The scientists indicate that mitochondrial disorders are responsible for cancer and numerous neurodegenerative diseases (such as Alzheimer's disease, multiple sclerosis or Parkinson's disease). The proper functioning of mitochondria and their number in the body system determine the general health and life expectancy. Ensuring the nutrients which are necessary for the proper mitochondria functioning may be a solution for the improvement of health and general well-being.
Mitochondria are microscopic cell structures with their own genome and their own protein synthesis engine. Mitochondria contain the enzymes which catalyse the transformation cycle called the Krebs cycle. As a result of these transformations, the energy is produced via the respiratory chain and then it is used during all life processes. The Krebs cycle is also a final stage of the decomposition of lipids, amino acids, and saccharides.
Considering the fact that mitochondria are a starting point for the mechanisms of using energy in the body system, they require special support and protection. This is made even more complicated by the fact that, with age, mitochondria become weaker and work less efficiently. For the proper functioning of mitochondria, we need to provide them a high enough supply of particular nutrients, including:
L-taurine – usually called "taurine". It belongs to a group of free amino acids (non-proteinogenic amino acids), that is such amino acids which are not a part of any structural protein. However, this does not mean that it is not important for the proper functioning of the body system. On the contrary, it is necessary for the smooth functioning of the brain and the nervous system.
Taurine is a deposit of a non-protein nitrogen. In the tissues and organs of the body system of an adult there are up to several dozen grams of taurine and its greatest concentration occurs in the muscles. The human body system has an ability to produce taurine. In small quantities it is produced in liver, brain, intestines, and skeletal muscle. However, these amounts are too small to fully cover the demand for taurine.
Taurine shows psychostimulant, thermogenic, anti-catabolic and anabolic properties. This is why it is gaining more popularity in supporting the body system. Also, its health promoting properties are valuable and this is why taurine is successfully used in the modern medicine, especially in neurology, cardiology, diabetology and hepatology.
Taurine is of a particular kind of natural psychostimulant – it has an influence on the two brain centres: the serotonergic centre (in which serotonin plays the role of a neurotransmitter) and the GABAergic centre (which depends on the gamma-aminobutyric acid – GABA). Stimulation with taurine leads to agitation, increased mobilization to physical and mental effort, extends the awakeness time as well as reduces the feelings of sleepiness and fatigue.
Contrary to caffeine and other alkaloids, the use of taurine does not result in unpleasant symptoms associated with an increase in blood pressure and inattention as well as it does not lead to a rapid decline in form after a temporary euphoria. It is often used by athletes because, supplemented before the workout, taurine improves the exercise capacity and leads to psychomotoric agitation.
Moreover, taurine reduces the breakdown of acetylcholine – a neurotransmitter which is used, i.a., by the brain areas which are involved in focusing attention, learning process, long-term planning etc. It improves the metabolism of glial cells and, indirectly, of all neurons.
This helps to improve memory and thinking processes. This results in the fact that we are not distracted, learn faster and better associate facts. It is especially important for people who work mentally, students and for those who consider the maintenance of continuously high mental activity as a priority.
Taurine supports the appropriate use of sodium, calcium and potassium in the body system, helps to keep cell membranes in a good condition, supports the proper hydration of tissues and thus it improves the efficient functioning of the brain.
Because of its strong anti-catabolic and anabolic properties, taurine is especially appreciated by athletes. It protects muscle proteins from unnecessary destruction, increases the sensitivity of the muscle tissues to insulin, facilitates the transport of creatine into the muscle (and thanks to that it can be used more effectively) and accelerates the regeneration after workout.
Thanks to regular use of taurine, the athletes are able to train more intense, they regenerate faster and can easier lean the body mass.
R-lipoic acid — a biologically active form of lipoic acid, one of the strongest antioxidants. Contrary to the inactive "S" form, R-lipoic acid shows greater absorption and stability, and thus has a better health promoting properties.
The producer of Mitochondrial Basic went a step further and made a supplement which contains the newly discovered form of R-lipoic acid – sodium R-lipoate. The research has proven that sodium R-lipoate has the highest bioavailability and stability of all the forms of lipoic acid and its maximum concentration in the blood plasma is reached already about 10–20 minutes after supplementation. Thanks to this, the preparation shows even stronger and more effective action than other specifics containing a standard form of R-lipoic acid.
The biggest advantage of R-lipoic acid is the ability to reverse the aging of mitochondria. By optimizing the energy transformation in mitochondria and preventing the release of mutagenic oxidants, R-lipoic acid alleviates the mitochondrial dysfunction of cells aging, and thus effectively reduces the risk of diseases associated with aging process.
R-lipoic acid shows strong anti-inflammatory properties. It helps to protect cells from oxidative stress, which leads to chronic inflammation which contributes to the development of numerous neurodegenerative diseases (such as Parkinson's disease or Alzheimer's disease). Moreover, it prevents the brain cells from dying and helps to improve the production of neurotransmitters, which improves cognitive skills.
PQQ – pyrroloquinoline quinone – is a vitamin-derived nutrient which belongs to a group of cofactors whose properties are similar to the properties of vitamin B group. The human body system cannot synthesize PQQ by itself, which means that we have to provide this micronutrient with food.
PQQ significantly affects life expectancy and the functioning of mitochondria. It starts the mitochondrial biogenesis – the rise of new mitochondria in aging cells. It also has a significant influence on the generation of new mitochondria. The more effectively functioning mitochondria we have, the better the body system functions.
Moreover, PGG shows neuroprotective properties. It stimulates the production and the release of nerve growth factor in the cells which contribute to the health of the brain. It supports cognitive skills, significantly improves memory, the speed of response, attention and concentration.
It is one of the strongest antioxidants, which means that it protects the mitochondria better than any other currently known antioxidant. The research shows that PQQ is up to 5 000 times more effective than other antioxidants (for example vitamin C). It effectively limits the number of free radicals, reduces oxidative stress and the inflammation caused by it.
PQQ prevents the accumulation of amyloid beta and alpha synuclein – the abnormal proteins that hinder or prevent the exchange of substances between blood and cells, and thus are the reason of numerous serious diseases (Alzheimer's disease or Parkinson's disease).
Moreover, it protects neurons that have been exposed to the action of abnormal proteins and modulates the functioning of genes responsible for mitochondria functions. These are the genes that are responsible for weight and the metabolism of sugars and fats.
Life Extension Mitochondrial Basics with PQQ combines the most effective known substances that have scientifically positive influence on mitochondria. The regular use of the product may help to improve memory and mental capacity, delays the aging process and protects us from numerous dangerous diseases associated with impaired functioning of the mitochondria.
The activity of mitochondria decreases with age. This results in a decrease in energy production in the body. It is recommended to help the work of mitochondria using a dedicated formulation. Proper supplementation improves mood and cognitive function.
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Vegetable cellulose (capsule), microcrystalline cellulose, candelilla wax, beeswax, stearic acid, silica, corn starch, acacia gum, calcium silicate.
Sodium is an important component of the intracellular fluids, and is a regulator of acid-base balance. Along with potassium affects the proper of growth and provides the proper functioning of muscles and nerves. The source of acquisition is table salt (NaCl) and bladderwrack, shellfish, bacon, beef, and of plant beets and carrots. People on salt-free diet should avoid, among others, spicy sauces and smoked meats and sausages.
Sodium deficiency is very rare, at heaving sweating after a long effort (e.g. in the marathon).
Excess sodium increases blood pressure (especially for the elderly), edema and increased thirst. Exceeding the daily dose of 14g a day can cause poisoning.
Taurine – non-protein amino acid containing sulphur, which is synthesized in the body from methionine and cysteine, present in sufficient amount in human or animal body (in the brain, heart and skeletal), although in some cases must be supplemented. Significantly affects the calcium content in the cells and stabilizes the water and electrolyte balance and maintains acid-base balance. Takes part in the synthesis of bile acids. In the body acts as a neurotransmitter and neuromodulator. It is an insulin-mimetic improving insulin metabolism, responsible for transport of nutrients (such as amino acids, glucose, creatine) to the cells and muscle tissue. These properties determine that it is a valued mono-preparation supplement and valuable addition to creatine and amino acid supplements, recommended for psycho-pchysically active people and athletes and other competitive sportsmen in pre- and post-workout periods.
Dosage: 3 grams per day.
R-ALA (R-alpha-lipoic acid) active form, having improved properties, and the potential of bioactive lipoic acid (ALA). Its bioactive potential is used in medicine in the diabetic neuropathy and cardiovascular prevention (slows down the formation of atherosclerotic lesions). In the sports supplementation, the properties of the insulin metabolism stimulation are used (sensitivity to insulin and glucose levels in the blood) and antioxidant potential of R-ALA and the assimilation of nutrients, improvement of creatine transport, storage of glycogen and amino acids in muscle tissue. Acid R-ALA is available in the form of mono-preparation supplements and advanced amino acid products, creatine, no-boosters and vitaminizing supplements, for purchase at www.muscle-zone.pl
Dosage: There are no standards of daily consumption
Pyrroloquinoline quinone (PQQ), otherwise known as methoxanthin, it is substance that was discovered quite recently. Admittedly, PQQ was discovered in 1979. However, it was not until 2003 that its properties were shown to be similar to those of B vitamins (for this reason, it is sometimes called PQQ vitamin).
Nonetheless, PQQ is not a vitamin but a vitamin-like substance because it does not meet all the criteria for this group. PQQ functions as a cofactor, thereby regulating enzyme activity.
It is a cofactor of many redox reactions with great antioxidant and anti-inflammatory potential. It has been shown to be more effective than the commonly used vitamin C.
Furthermore, PQQ stimulates the biogenesis of mitochondria (increases the body’s efficiency, improves energy production), helps maintain normal protein deglycase DJ-1 levels (protects against oxidative stress), is involved in NGF synthesis (promotes the production of new neurons and regeneration of myelin sheaths).
All these properties may make PQQ supplementation a perfect way to improve general quality of life (improved sleep efficiency, increased energy levels, reduced stress and fatigue and a beneficial impact on mood).
Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at www.muscle-zone.pl
Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).
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