Glucosamine is one of the most basic and most used supplements in the prevention of bone system. Regular supplementation contributes to the regeneration of articular cartilage (inhibition of chondrocyte catabolic activity and proteolytic enzymes) and the relief of arthritis, including pain reducing. Glucosamine has a significantly higher activity in combination with chondroitin. Both of these substances have a synergistic (complementary) effect. Interestingly, glucosamine may also increase the synthesis of hyaluronic acid - a substance highly regenerating skeletal elements.