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|Servings: 300mg 100 caps.|
Now Foods Double Strength Silymarin is a dietary supplement with double strength, containing a milk thistle extract standardised to the content of at least 80 per cent of silymarin. Moreover, the preparation contains a dandelion extract and an artichoke leaf extract. The carefully selected ingredients of the preparation support the functioning of the liver – they improve detoxification, help to treat liver disorders, and have a beneficial effect on the lipid profile.
Silymarin is a flavonoid complex contained in the fruit of milk thistle (Sylibum marianum). Milk thistle is thought to be one of the most important medicinal plants; it has been used for many years in liver disorder treatment. The Latin name Silybum was given to the plant as early as 100 years B.C. by a Greek doctor Dioscorides, and the effects of the plant were described in the 1st century A.D.
Common dandelion root (Taraxacum officinale) helps to increase the secretion of gastric juice and bile, and it improves its flow through the bile duct. The material also supports digestive processes and helps to reduce blood glucose levels. Dandelion root is used, for example, in the case of liver failure and the initial stage of diabetes, as well as in order to facilitate digestion and increase urination.
Artichoke leaves (Cynara scolymus) is a material with antioxidant properties that has cholepoietic and cholagogic properties; it also helps to reduce cholesterol and triglyceride levels in blood serum. Artichoke extracts are used mainly in the case of deteriorated liver functions, digestive system disorders, and elevated cholesterol levels.
Silymarin as a flavonoid complex
The flavonolignan complex found in Sylibum marianum contains: silibinin and its isomer isosilibinin, as well as silidianin, and silicristin. According to scientific reports, silibinin is the most active component of the complex. The substance has a complex mechanism, and its activity goes beyond liver diseases and can also constitute an element of cancer or type 2 diabetes prevention.
Protection against free radicals
The milk thistle extract has a protective effect on hepatocytes. It has been demonstrated to protect liver cells from the oxidising activity of free radicals by increasing the levels of dismutase, peroxidase, glutathione, and glutathione peroxidase in them. Silibinin also helps to inhibit the production of prostaglandins, connected with lipid peroxidation.
Blocked toxin permeation
Silibinin prevents toxic substances (for example amanitin) from permeating inside hepatocytes, thanks to which it reduces the risk of their death. Moreover, it strengthens the membranes of liver cells and stabilises their structure.
In connection with those properties, silymarin is used in the case of poisonings (for example death cap). The symptoms of the poisoning are induced by amatoxins, synthesised by three types of fungi – Amanita, Galerina and Lepiota, and responsible for inhibiting protein synthesis in cells. The substances contained in milk thistle extract stimulate RNA polymerase and intracellular translation, which helps to increase ribosomal RNA synthesis and, in turn, the synthesis of both structural and functional proteins in liver cells.
Application in cirrhosis
According to recent reports, milk thistle extract can also be applied in the case of cirrhosis caused by alcoholism. Using a Sylibum marianum extract has a beneficial effect in the form of improved laboratory values, such as: enhanced prothrombin time, reduced transaminase concentration, and improved histopathology image. Moreover, a reduced incidence of encephalopathy was observed. The benefits of using the extract can also be experienced by people with non-alcoholic steatohepatitis (NASH) and drug-induced hepatic injury.
Silibinin has been demonstrated to exhibit anticancer properties, concerning for example prostate adenocarcinoma, colon cancer, breast cancer, and lung cancer. The mechanism of silibinin’s activity is probably based on the regulation of cytokine secretion and functioning, DNA and growth factor production, as well as proliferation inhibition and cancer cell apoptosis induction. What is more, the substance exhibits cytoprotective properties and reduces the adverse reactions caused by cytostatic drugs.
Silymarin in type 2 diabetes treatment
The antioxidant properties of the extract can also be used in the case of type 2 diabetes. As most people know, oxidative stress contributes to pathological lesions that lead to distortions of carbohydrate metabolism. Taking silymarin reduces the level of HbA1c, total cholesterol, triglycerides, fasting glucose, as well as helps to improve general blood sugar concentration.
To sum up, Now Foods, Double Strength Silymarin is a dietary supplement that improves liver functions and helps to detoxify the organism. The preparation is recommended for people who use substances that have a harmful effect on the functioning of the liver, including anabolics and various drugs, as well as for those who drink alcohol excessively or follow an improper diet. Moreover, the preparation can be helpful in the case of insufficient bile duct patency, digestive disorders, liver failure, and after hepatitis.
The high dose of silymarin. I would recommend it not just to people who are struggling with various symptoms of the liver and digestive problems. The product should be used in people with poorly balanced diet rich in fat, abusing alcohol, drugs and pharmaceuticals (contraceptives, steroid hormones). The product is an excellent alternative to the popular pharmaceutical drugs based on silymarin. Strongly outperform its effectiveness. People taking milk thistle should also consider the use of silymarin. Silymarin in milk thistle is contained only 2-3% of all components, so its effects may not appear.
Now Foods is a company with years of experience in the industry that offers a wide range of nutrients and dietary supplements. Brand is known for its high-quality products designed for hair and nails and supplements supporting the immune system. The offer includes the antioxidant supplements, antibacterial supplements, reducing appetite supplements, products supporting the reduction of body fat and improving digestion. All products are made from natural ingredients.
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Cellulose (capsule), Cellulose Powder, Silica and Magnesium Stearate (vegetable source).
Flavonoids are derivatives of chromone, their rich source of vitamin P (includes routine and quercetin and other flavonoids). They have the ability to restore flexibility of blood vessels, facilitating the work of the heart muscle (antiatherogenic action). They are an antitoxin for myocardial toxication with lactic acid. Used in inflammatory conditions of the urinary system, also they have a diuretic effect. Delay diabetes, help to keep the body's balance of sugar. The raw material of flavonoids are, for example, elderberry (leaves and fruit), bearberry leaves and birch, horsetail herb, knotweed. They are a shield against ultraviolet, and the protection of the body when exposed to radioactive elements during cancer radiation therapy. The most popular of them - routine, can be used without any side effects, even for a period of one year. Flavonoids are poorly soluble in water, and hence usually their alcoholic extraction are used
Artichoke (Cynara scolymus) - a plant of the Asteraceae family, rarely cultivated in Poland. The raw food material is its inflorescence (Inflorescentia Cynarae) and herbs (Cynarae scolymi). Inflorescence and herb provide a lot of substances, such as proteins, cynarin, flavonoids insulin, carotene, polyphenolic acids, triterpenes, carbohydrates and vitamins (B1, B2 and C). It is anti-inflammatory, antioxidant, and diuretic and choagogne, lowers LDL cholesterol (by reducing the activity of the enzyme HMG-CoA reductase, it protects the liver, is antitoxin for carbon disulfide (Cynareina.). It is used in the diuretic preparations, in rich in proteins and carbohydrates and vitaminizing supplements. Improves insulin metabolism of the pancreas., used as a component in pro-health supplements supporting digestion, lowering cholesterol levels, herbal blends (in combination with extracts of. milk thistle, B group vitamins, and others).
Dosage: 600-1000 mg per day.
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