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Aliness Selenium SeLECT is a product based on selenomethionine, an organic compound that naturally occurs in a human body, characterized by a high degree of utilization by the system. By strengthening the antioxidant barrier and improving the functioning of many systems, such as cardiovascular, immune, osteoarticular, thyroid function and having an effect on the preservation of high fertility, it supports the maintenance of a good condition of the body. The product comes in easy-to-swallow tablets, allows for comfortable supplementation of selenium, also by vegetarians.
Selenium – a relatively widespread micronutrient. It was first described by the Swedish chemist Jöns Jacob Berzelius in 1817. Selenium was considered to be toxic for a long time. However, due to its activity and the fact it appears in active centers of some enzymes, especially antioxidants, selenium was hailed as an element important for maintaining the proper condition of the entire human system. It occurs in almost the entire range of food products, starting from meats, through eggs, dairy products (mainly cheeses with opposite correlation to fat content), fish, mushrooms, nuts (especially Brazilian), vegetables (mainly cabbage, broccoli, garlic and legumes), numerous cereal products, ending on water.
The best assimilable forms of selenium are its organic forms, e.g. selenomethionine and selenocysteine. The non-organic compounds such as selenates and selenides are less assimilable, however, due to the frequency of their occurrence in the food they also play a role in covering the selenium demand. Theoretically, the body’s daily demand for this element is about 45-70 μg. Nevertheless, there are regions such as the United States, where the quantity of selenium consumed exceeds the recommended daily dose by twice. The level of selenium demand increases with unfavorable environmental conditions, especially those that cause increased intra-organic oxidative stress. This occurs in case of a polluted environment such as smoke, among smokers, in people exposed to psychological stress, or people who have been subjected to hard physical work, including athletes. Selenium is also important for people susceptible to neoplastic changes. It is assumed that the most beneficial level of selenium in blood plasma is 70-150 μg/l. Although some effects may be induced directly, the most important properties of selenium are manifested in the form of selenoproteins, circulating in the human body.
Selenoproteins – protein compounds that in their structure contain selenium, which plays an important role in ensuring adequate activity of given molecules. The most important selenoproteins in a human body are glutathione peroxidase, iodothyronine deiodinase, and thioredoxin reductases. They perform numerous functions important for the proper functioning of the system:
As part of the glutathione peroxidases, selenium strengthens the antioxidant barrier necessary for the maintenance of the intra-organic redox balance.
Through thioredoxin reductases, it participates in the reduction of protein disulfides and thioredoxins, as well as it engages in the reproduction of genetic material and controls cellular existence or degradation in the process of apoptosis.
Through deiodinases, selenium removes iodine from certain structures, affecting the activity of the compounds it is a part of, e.g. thyroid hormones.
Enabling the action of other selenoproteins, it also takes part in preventing oxidative damage, supporting the immune system, ensuring the correct course of the synthesis of intra-organic structures, calcium management and allows to maintain the required fertility.
Increased efficiency of the antioxidant barrier
As part of certain antioxidant enzymes, especially glutathione peroxidases and by affecting the performance and quality of the activities performed by glutathione, it promotes the neutralization of hydrogen peroxides and organic peroxides with the oxygen bridge. Enabling an effective reduction of reactive oxygen species, it helps to restore the redox balance in the period of increased oxidative stress.
Selenium, as one of the few mineral elements, is credited for significant anti-cancer properties based on several mechanisms:
By initiating changes in thiol groups, it destroys the correctness of tumor cell signaling, which reduces the activity of transcription factors, leading to blocking the development of pathological changes in the body.
It interferes in the chromatin structure by destroying the genetic material of abnormally changed cells.
It inhibits the rate of angiogenesis, leading to the weaker nutrition of pathological cells.
Acting as a prooxidant in case of abnormally changed spots, it disturbs the redox balance in the vicinity of tumor cells. By promoting the emergence of reactive compounds attacking abnormally changed cells, selenium leads them to apoptosis that destabilizes their structure.
Maintaining good condition of the circulatory system
Maintaining the proper excitability of the fourth isoenzyme of glutathione peroxidase, selenium reduces the amount of oxidative damage of the compounds circulating in the vessels, including cholesterol transmitted by lipoproteins and phospholipids. It reduces the aggressiveness of the environment created in the cardiovascular system, which has a positive effect on its condition.
Limiting oxidative damage in the nervous system
By increasing the efficiency of the antioxidant barrier in the nervous system, selenium protects its structures against oxidative damage. Maintaining neuronal stability, it supports the correctness of neurotransmission and prolongs appropriate functioning of the nervous system. The significance of selenium in this process is demonstrated by the fact that the body maintains selenium high concentration in the central nervous system, even when the level of the micronutrient in other parts of the body decreases.
Proper functioning of the thyroid gland
The significant role of selenium in maintaining thyroid function is confirmed by its considerable accumulation within the organ compared to other spots in the system. Selenium, with the use of deiodinases that convert thyroxine (T4) to triiodothyronine (T3) in the deiodination process, engages in transformations and creation of the quality of thyroid hormones activity. By providing the required excitability of glutathione peroxidase, selenium reduces the oxidative stress that arises in the gland due to the production of thyroid hormones. Such protection becomes particularly important in case of iodine deficiency, during which the synthesis of TSH prevails and the emergence of free radicals that accompanies its formation. By limiting the extent of uncontrolled oxidation processes, it increases the structural stability of the gland and reduces the occurrence of lesions that would disturb its function, including degradation and fibrosis. It minimizes the appearance of simple goitre and autoimmune inflammation and prevents hypofunction.
Support for the functioning of the immune system
It is argued that by affecting the expression of interleukin-2 receptors, selenium promotes development, transformation, and maintenance of the optimal excitability of numerous components of the immune system, e.g. T, B lymphocytes, or NK cells. The appropriate level of selenium is necessary for proper phagocytosis, required to maintain the efficiency of immunoglobulin production, particularly IgG. It is responsible for the proper release of prostaglandins. It is an indispensable element allowing to maintain the balance between anti-inflammatory and proinflammatory macrophages. Optimizing the mutual ratio between these macrophages, it counteracts the emergence and spreading of inflammation.
By slowing the formation of aggressive forms of RNA viruses, selenium prevents infections. It is also believed to exert a beneficial effect on the body infected with HIV or Hepatitis B.
Maintaining the good condition of mental health
It is beyond any doubt that selenium is essential for maintaining well-being. Although no sufficiently convincing mechanism has been found yet, it is postulated that its involvement in antioxidant processes is of the greatest importance. By protecting neurons against degradation induced by oxidative stress, it ensures the proper signaling as a result of the activity of appropriate neurotransmitters, including those responsible for creating good humor and a positive attitude towards the world. On the other hand, people with permanent deficiencies of selenium may develop depressive conditions.
Ensures the required fertility
As an essential component in the testosterone synthesis and as a microelement responsible for the process of formation and maturation of sperm cells, it affects the maintenance of the required male fertility. By counteracting uncontrolled oxidation processes, it minimizes the degradation of sperm structures such as the numerous mitochondria necessary for its movement. By supporting mitochondria, selenium improves sperm mobility, which increases the likelihood of fertilization.
Consequences of selenium deficiency
A deterioration of the mental state is quickly noticeable, though rarely directly identified with selenium deficiency symptom. Selenium deficiencies cause anxiety, aversion to the world, confusion and general depression. In addition, the immune, antioxidant, and detoxification spheres of the immune system are also significantly weakened. An increase in the susceptibility to infection becomes noticeable, followed by a decrease in the condition of the body. The probability of formation and development of abnormally changed cells increases. The efficiency of numerous systems, including osteoarticular and cardiovascular systems deteriorates. The most characteristic diseases caused by selenium deficiencies are Kashin-Beck disease, resulting in the destruction of cartilage tissue located in the joints, and Keshan disease, contributing to the formation of pathological lesions within the heart.
Analogously to other elements, both selenium excess and shortfall may cause adverse effects. The most characteristic symptoms of excessive intake of selenium include general weakness, nausea and diarrhea, deterioration of nails, increased hair loss and characteristic garlic smell in the mouth. Therefore, in the period of increased supply of selenium, it is worth to perform periodic check-ups for the amount of selenium in the system or, if it is impossible to perform such tests, make periodic breaks in its supplementation.
Bioavailability of selenium
The bioavailability of selenium depends on the chemical form in which it was introduced into the digestive system. Poorly-used compounds include non-organic forms such as selenides and selenates. Organic compounds such as selenocysteine and selenomethionine are much better in this matter. Besides selenium, they also provide the body with essential amino acids. Supplementation with organic selenium compounds ensures its adequate concentration, high bioavailability and does not provide allergens, as in case yeast-based products.
In conclusion, Aliness Selenium SeLECT is a supplement providing selenium in the form of easily digestible selenomethionine. By improving the efficiency of the antioxidant barrier, preventing the development of pathological cells in the body and increasing the effectiveness of the immune system response, it ensures the homeostasis of the body. By maintaining the undisturbed course of numerous processes occurring in the system, the supplement supports the functioning of the circulatory and nervous systems, as well as improves the work of the thyroid gland and liver. It is essential to maintain the required fertility, especially in men, and also allows maintaining a good mood and a positive attitude towards the surrounding world. Aliness Selenium SeLECT as a yeast-free agent eliminates possible allergens.
Supplementation with preparations containing selenium is recommended especially for people who consume a lot of carbohydrates and highly processed products. Sweet pastries, sweetened cereal products, and sugar may entirely destroy selenium. Our product contains a high, optimal, healthy dose of selenium, so 1 tablet a day is enough to fully cover the systemic demand. If you are also supplementing preparations with zinc, do not take them together with selenium. These elements are antagonists. If administered at the same time, their absorption is weaker and the general bioavailability is reduced.
Aliness is a Polish brand owned by Medicaline. The company has advanced development and research facilities and meets the demanding European Standards of Production and Storage based on the pharmaceutical standard GMP and HACCP. A team of experienced specialists supervises the quality of manufactured dietary supplements. The company uses only the highest quality certified raw materials, often occurring in patented forms.
Aliness cooperates with the research laboratories accredited by the Main Pharmaceutical Inspectorate - SGS Poland and J.S. Hamilton Poland S.A., and also with the National Institute of Medicines, responsible for quality and safety control in research and development. Many Aliness products have an ecological certificate, which is a guarantee of the lack of use of artificial fertilizers, pesticides and chemical plant protection products at all stages of the production of the raw material.
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Selenium (element, chemical symbol Se, atomic no. 34, from chalcogenide, it is present in several allotropic forms). It is supplied the body with food in the form of seleno-amino acids (selenomethionine - gathering supplies, and selenocysteine – a component of glutathione peroxidase, deiodinase and seleno-proteins). Regulates the functioning of the thyroid gland. It affects the growth and development, including sexual development (by increasing production and sperm motility). It affects the flexibility of the tissue, removes some of the toxins from the body and destroys cancer cells and reduces the severity of menopause in women. Natural products containing selenium are seafood (sea fish, oysters, bladderwrack) and vegetable products (broccoli, onions, wheat germ, bran, tomatoes) and animal products (poultry, eggs). It is also included in the composition of vitamin-mineral and mineral supplements. Selenium supplementation is recommended as a dietary supplement of active people having diet poor in this element, and as a factor increasing the body's immunity.
Selenium deficiency increases the risk of developing cancer and heart disease. Symptoms of selenium deficiency are: cardiomyopathy, growth stoppage, disorders of detoxification processes which may lead to damage to the kidneys and liver.
An excess of selenium can lead to selenosis (the disease, the symptoms are: loss of hair, nail cracks, lesions).
daily demand of selenium for pregnant women 65 mcg; nursing mothers 75 mcg; men 7 mcg.
L-selenomethionine is a selenoamino acid and organic form of selenium. It is a combination of selenium with methionine (about 40% of selenium and 60% of the amino acid methionine per molecule) in which a sulphur molecule is replaced by selenium.
This form is absorbed very effectively via the digestive tract. It is believed that the bioavailability of selenium from L-selenomethionine is even 1.5-2 times greater than its non-organic forms. It is estimated that its bioavailability may exceed 90%. Furthermore, the half-life of L-selenomethionine is much longer than in non-organic forms – it is 252 days. This means that the absorbed selenium is accumulated for a long time in the body.
Selenium is a component of many key biochemical pathways. It helps protect the body from oxidative stress, prevents atherosclerosis, supports the immune system and brain function and optimises thyroid function. It has been demonstrated that selenium as L-selenomethionine may, among others, reduce the secretion of proinflammatory cytokines in female patients with Hashimoto’s thyroiditis..
As a dietary supplement, L-selenomethione is most often used to support thyroid, cardiac and immune function and stabilise cholesterol levels.
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