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|Servings: 60 tab.|
Blackstone Labs Chosen 1 is an anabolic-androgenic agent based on 1-androstene-3b-ol-17-one, a substance also known as 3b-hydroxy-5a-androst-1-en-17-one; 1-Dehydroepiandrosterone and 1-Androsterone, in short 1-Andro or 1-DHEA, a compound bearing a structural resemblance to 5-DHEA.
DHEA (5-dehydroepiandrosterone) is a steroid hormone synthesized endogenously in the human organism from cholesterol, mainly in the adrenocortical reticulum layer. The greater part of it, located in the peripheral tissues is converted to dehydroepiandrosterone sulphate (DHEAS). Collectively, both forms reach the highest concentration among androgens in the organism, exceeding from a few to several thousand times the amount of remaining, individual androgens. DHEA is responsible for the proper functioning of many systems, particularly: cardiovascular, nervous and immune. It works both independently through specific receptors as well as indirectly through vast number of derivatives, such as: androstenedione, androstenediol, testosterone or estrogen. Exhibiting hydrophobic properties, it can also function without influencing the receptors. Affecting the stimulation of androgenic receptors (AR) it promotes the growth of many organism structures, including muscle tissue. Inhibiting the activity of type 1 11β-hydroxysteroid dehydrogenase (11bHSD1) it slows down the rate of created cortisol, therefore limiting stress and myocytes degeneration. Engaging in the maintenance of proper DHEA:cortisol ratio it supports the preservation of the good mental condition. By modulating the response of GABAA, NMDA and sigma receptors, located in the nervous system, it influences the functioning of any given system, and therefore the functioning of the whole organism. By blocking the production of cortisol, intensifying the AR signalization and modulating the activity of the receptors triggered by peroxisome proliferators (PPAR), it increases the glucose tolerance, eliminates the heightened insulin resistance and limits the accumulation of spate fat tissue. Maintaining a certain balance and high availability of DHEA is ensured by its conversion into DHEAS which is in definite majority bond by globulin binding sex hormones (SHBG). Permanent reduction of the concentration of a given compound leads to adrenopause and, associated with it, the weakening and aging of the organism. As a compound immune to 5α-reductase and aromatase catalyzed transformations it does not succumb to direct conversion to more aggressive hormones, i.e. dihydrotestosterone (DHT) and estrogens, although its derivatives are capable of doing this.
As a consequence of the shift of the double bond in the 1-DHEA structure in relation to 5-DHEA from 5 to 6 carbon positions to the place located at the 1 and 2 carbon atoms of the sterane, some of the properties presented by the initial compound have changed.
1-androstene-3b-ol-17-one – exhibits no ability to convert into testosterone (4-testosterone), but rather to structurally similar 1-testosterone. This transformation in the human organism can undergo in two ways with use of 3β-hydroxysteroid (3b-HSD) and 17β-hydroxysteroid dehydrogenases (17b-HSD) allowing the formation of androstenedione and androstenediol, respectively. Subjecting the androstenedione to 17b-HSD activity and catalyzing the transformation of androstenediol by means of 3b-HSD allows the synthesis of 1-testosterone which is mainly responsible for the specific effects caused by the administration of 1-DHEA.
1-testosterone (17β-hydroxy-5α-androst-1-en-3-one) is a steroid compound also found under the name: dihydroboldenone, in short DHB, 1-Test or 1-T. In its structure the location of the double bond located at position 4 in the case of traditional testosterone was changed to the position at 1 carbon atom in ring A and an additional hydrogen atom was introduced between the ring A and B of the sterane. Due to this structural changes, 1-testosterone is insusceptible to aromatase, which allows for the elimination of the effects associated with the increased activity of female hormones. By doing so, it eliminates the occurrence of gynecomastia and excessive retention of water and fat. It is also a substrate of little value for 5α-reductase, which is the reason for blocking the formation of high concentrations of 5α-dihydrotesotsterone (DHT). Due to the definitely stronger binding to the appropriate receptors than does 4-testosterone, it should not be assumed that there are no pimples, oily skin, prostatic hyperplasia, or male pattern baldness. Considering 1-Test as an independently acting compound, it can be presumed as a more anabolic agent than traditional testosterone, which is reflected in the ratio of anabolic-androgenic properties of 200:100. As a consequence of minimal ability to convert into ordinary DHT, it might not, in certain naturally occurring conditions, so optimistically go ahead the made assumptions. Among relatively small number of side effects, most common are drowsiness and fatigue, the cause of which is yet to be definitely ascribed. Sometimes, a loss of libido is reported.
1-Andro on a low scale by itself, stronger through its metabolites, including the most numerous 1-androstenediol (1-AD) and the most potent – 1-testosterone; increases the anabolic processes in the muscle tissue structures and contributes to the loss of excess fat stored in the organism. In a decisive way it improves strength and endurance presented while performing resistance training.
1-DHEA, similarly to 5-DHEA and 1-testosterone, does not undergo aromatization to estrogens under the influence of aromatase. However, unlike 5-DHEA it additionally exhibits much weaker interaction with estrogen receptors, making it much safer compound form the perspective of complications caused by increased activity of female hormones. On the other hand, one of its derivatives, 1-androstendion is a substrate for estrogens, but increased risk of developing gynecomastia is not observed as an effect of using 1-DHEA.
1-Dehydroepiandrosterone due to some androgenic activity rises the probability of acne occurrence, hair loss, or prostatic hypertrophy. What is more, it has the tendency to increase the low density lipoprotein (LDL) concentration and lowers the high density lipoprotein (HDL) concentration, which may result in negative influence over shaping of the lipid profile. Despite the absence of methylation process it still might lead to deterioration of liver function indicators. Its intake may also increase the kidney load and rise the blood pressure.
3b-hydroxy-5a-androst-1-en-17-one unlike 1-testosterone, does not induce lethargy and discouragement to take action, but in contrast, a positive influence on the mental state and overall productivity.
Fusing, in the product, the base form of 1-DHEA together with its two advanced forms undecanoate and caprylate allows for the improvement of both bioavailability and the potency of the initial compound.
Blackstone Labs Chosen 1 is an effective anabolic-androgenic agent based on the pre-prohormone 1-testosterone that enables significant growth of huge and dense muscle mass, without raising the estrogen activity. By limiting the water accumulation and promoting excess fat tissue burning this product supports obtaining proper muscle separation and improvement in silhouette reception. Due to its potency, this formulation is addressed for experienced people.
This formulation should not be used in the case of any disorders in hormonal management.
For this product, it is recommended, a maximum of 6 weeks duration of the intake cycle.
After completing this formulation intake cycle it is suggested to take a PCT (Post Cycle Therapy) type supplement.
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|per 1 tablet||amount||%DV|
|1-DHEA Blend:||65 mg||-|
|1 androstene-3b-ol, 17-one|
|1 androstene-3b-ol, 17-one Undecanoate|
|1 androstene-3b-ol, 17-one Caprylate|
Microcrystalline Cellulose, Phosphatidylcholine, HydroxyPropyl-beta-cyclodextrin, Phytosterol, Stearic Acid, Magnesium Stearate, Starch, Titanium Dioxide, Silica, FD&C Red #40.
DHEA (dehydroepiandrosterone) is the base product for the production of the hormones, estrogen, progesterone and testosterone, which are produced by the adrenal cortex, having androgenic action and anabolic effects. It works on the nervous system, reducing feeling of stress. It speeds up the metabolism by limiting the formation of adipose tissue. It has an impact on the insulin metabolism. Rarely used in sports supplementation, it is used in supporting sports condition for men aged 40+.
Dosage: Up to a few hundred mg per day, depending on individual needs.
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