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HI-TECH Pharmaceuticals 1-AD is a potent anabolic-androgenic product based on the combination of 1-androstene-3b-ol-17-one and 5a-hydroxy Laxogenin. Its activity promoting the growth of 1-testosterone and testosterone, boosts significantly the anabolic potential of the body.
1-androstene-3b-ol-17-one is a steroid chemical compound, other than 3b-hydroxy-5a-androst-1-en-17-one, commonly referred to as 1-Androsterone and 1-Dehydroepiandrosterone, or in short 1-DHEA or Andro-1; it is structurally similar to Dehydroepiandrosterone (5-DHEA) in respect of which the position of the double bond in cyclopentanoperhydrophenanthrene has been shifted from the position between 5 and 6 carbon atoms to the location between 1 and 2 carbon atoms of the sterane.
5-DHEA is a steroid which acts as a hormone whose action exerts a significant influence on the hormonal balance of the body and the associated correct functioning of numerous systems, particularly circulatory and immune systems, reproduction, or mental state. It has the highest concentration among all androgens. Synthesis of the compound taking place mainly in the reticular layer of the adrenal cortex depends on the proper availability of the necessary precursor, for example cholesterol, and the required efficiency of the enzyme apparatus. It is a crucial starter compound for synthesis of many steroid compounds, including: androstenedione, androstenediol, or testosterone, through which it causes some of the effects attributed to its activity. By enhancing response of androgen receptors (AR), it initiates and intensifies the pace of anabolic processes taking place in many areas in the body, including muscles and bones. By blocking 11β-hydroxysteroid dehydrogenase type 1 (11bHSD1), it reduces the amount of cortisol, reducing intra-arterial stress and improving mood. By activating androgen receptors, reducing cortisol production and influencing the excitability of peroxisome proliferator-activated receptors (PPAR), it decreases insulin resistance, improves insulin action, increases glucose tolerance, thereby reducing the size of stored body fat and enhancing nutrition of structured cells, including muscle tissue. As a compound that does not bind to sex hormone-binding globulins (SHGB), it retains high activity and readiness to convert into many more active derivatives. It is not susceptible to catalytic activity of 5α-reductase and aromatase, and thus does not convert directly to 5α-dihydrotestosterone (DHT) and oestrogens. Although it may affect oestrogen receptors to some extent, it does not bring along effects associated with their excessive, unfavourable activation.
Similarly to 5-DHEA, 1-Androsterone undergoes transformation catalysed by 3β-hydroxysteroid dehydrogenases (3b-HSD) and 17β-hydroxysteroid (17b-HSD), however, the conversion product is 1-testosterone, not ‘traditional" testosterone.
1-testosterone is a chemical compound with sterane structure, often called dihydroboldenone, or in short DHB, 1-Test or 1-T. Unlike its ‘traditional’ counterpart, the double bond in ring A of cyclopentanoperhydrophenantran is located at 1 carbon instead of at 4. In addition, sterane has an additional hydrogen atom between the A and B rings. As it binds strongly to the receptors assigned to testosterone, it arouses anabolic processes in selected areas, including muscle tissue. It has enhanced anabolic activity, confirmed by a 200:100 ratio of anabolic-androgenic properties, making it a much more potent anabolic compound than the ‘traditional’ testosterone. Due to significant structural changes, 1-testosterone is not sensitive to transformations catalysed by aromatase, and therefore does not cause side effects associated with increased activity of female hormones, for example excessive accumulation of fat or water, or the development of gynaecomastia. In addition, it is an unattractive substrate for 5α-reductase, which partially limits its conversion to 5α-dihydrotesotsterone (DHT). Despite this, the possibility of developing cutaneous pimples, androgenic alopecia or prostatic hyperplasia can not be completely ruled out. Frequently reported side effects include increased fatigue and drowsiness, and sometimes worsened libido.
1-androstene-3b-ol-17-one, like its highly anabolic 1-testosterone derivative, does not undergo aromatisation. Although certain tendency to activate oestrogen receptors has been observed (weaker than in case of 5-DHEA), it is considered to be relatively safe against undesirable side effects associated with the increased excitability of oestrone. As in the case of 1-testosterone, it is possible to find conditions conducive to hair loss, or the appearance of cutaneous pimples. However, these side effects are milder than in the case of testosterone. What is more, drowsiness and discouragement, which are attributed to 1-testosterone, have not been observed. On the contrary, there is an increase in motivation and energy to act. On the other hand, adverse effects may be observed, such as increase in kidney and liver strain, elevation of blood pressure or change in the lipid profile manifested in the reduction of high density lipoprotein (HDL) with simultaneous increase in the level of low density lipoprotein (LDL).
5a-hydroxy Laxogenin is a plant steroid compound from the group of brassinosteroids, otherwise known as: Spirostan-6-one, 3-hydroxy-,(3β, 5α, 22ξ, 25R) - or 6-Oxotigogenin, most often identified with Smilax sieboldii, an evergreen from the Smilacaceae family, which grows in the form of collorps in eastern Asia, mainly China and Japan.
Brassinosteroids are a group of chemical compounds belonging to the plant kingdom, which mainly play the role of hormones. In accordance with the assigned function, they allow embryo development, germination, shaping of the plant, ensure the survival of the species and allow the plant to die. Throughout their life, plants also control numerous internal processes, including photosynthesis, and are responsible for proper water management or breathing. Structurally, they are steroids, which are characterized by the presence of several hydroxyl groups at sterane ring A. This means that they have certain structural features in common with many hormones of the animal world, especially of insects, which allows them in some situations to affect human membrane receptors. It is assumed that due to the above mentioned capacity, they increase the level of testosterone and boost the body's anabolic potential.
Spirostan-6-one, 3-hydroxy-,(3β, 5α, 22ξ, 25R) - enhances the synthesis of endogenous testosterone by triggering the reaction of selected receptors in the human system. This substance is resistant to transformations catalysed by aromatase and 5α-reductase, therefore it does not serve as a precursor for oestrogens or DHT, due to which it does not create a threat in terms of unfavourable over-activity of given hormones.
By creating a complex combining the advantages of 1-Dehydroepiandrosterone and 6-Oxotigogenin, it is possible to effectively increase the anabolic potential of the body. By raising the level of testosterone and 1-testosterone, it strongly stimulates receptors responsible for promoting anabolic processes occurring in the muscle and bone tissue. The developed muscle mass becomes more defined and looks better due to additional properties of 5a-hydroxy Laxogenin which lowers cortisol levels, increases thyroid hormone activity, improves insulin performance and reduces insulin resistance of hepatocytes and myocytes, and also due to action of testosterone initiating fat burning.
None of the compounds undergoes aromatase-catalysed transformations, and in comparison to weak direct effect activating oestrogen receptors demonstrated by 1-DHEA, they do not pose a direct threat in terms of excessive female hormones activity. Sensitive people may experience adverse effects of increased excitability of male hormones. Their use may increase the liver strain, although in comparison with other anabolic agents, e.g. anabolic-androgenic, especially methylated ones, this fact should be significantly less burdensome.
Integrating one molecule into the 1-Androsterone product that forms one molecule with decylic acid ensures the required purity and action time of the substance. In turn, the use of CyclosomeTM technology during the encapsulation process increases the bioavailability of active compounds, thus increasing their efficiency.
HI-TECH Pharmaceuticals 1-AD® is an effective anabolic agent based on substances enhancing systemic synthesis of anabolic-androgenic hormones. By raising the levels of testosterone and 1-testosterone, it creates a favourable environment for the rapid development of muscle tissue, meanwhile strengthening the skeleton that supports musculature. By initiating weight loss, it promotes development of good quality muscle mass. HI-TECH Pharmaceuticals 1-AD® is an ideal product for those who want to achieve stunning results, without burdening their organisms with numerous side effects associated with such products.
|per 1 tablet||amount||%DV|
|1-androstene-3b-ol, 17-one Decanoate||75 mg||-|
|5a-Hydroxy Laxogenin Acetate||50 mg||-|
Microcrystaline Cellulose, Phosphatidycholine 75%, Hydroxypropyl Beta cyclodextrin (HPβCD), Phytosterols, Magnesium Stearate, Silica, FD&C Blue #2, FD&C Red #40
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