• Anti-atherosclerotic and cardioprotective properties
• Reduces migraine attacks and tension headaches
• Supports transformations of proteins, fats and carbohydrates
• Determines the proper functioning of nervous system
• Promotes the proper energy metabolism
• Helps to maintain lipid balance
• Time-released tablets
• Reduces the flushing symptoms

Doctor's Best Niacin Time-Released With Niaxtend is a dietary supplement which contains niacin in form of long-acting nicotinic acid, which is released for 8 hours, so that it prevents flush effects (sudden redness, feeling hot, tingle, itching of face, shoulders and breast). One tablet contains 500 mg of niacin.

Niacin (vitamin B3, vitamin PP) is an umbrella term for nicotinic acid and nicotinic acid amide which are substrates of the synthesis of a coenzyme, nicotinamide adenine dinucleotide NAD⁺, with its phosphorylated form, NADP⁺, which are necessary for the proper conduction of metabolic processes. It is one of the most durable vitamins, soluble in water or alcohol.

Niacin is essential for the proper functioning of the central and peripheral nervous systems, participates in the synthesis of hormones (thyroxine, insulin, sex hormones) as well as improves blood circulation. Properties of niacin result in a wide spectrum of its application in medicine.

Discovery of niacin
The discovery of this vitamin is associated with a diseases caused by its deficiency – pellagra (Alpine scurvy). In 1926, a hypothesis by Goldberger was presented. It said that the deficiency of a vitamin, which was known then as G or PP (“prevention of pellagra”), is caused mainly by improper eating habits – high consumption of corn (poor in niacin) and lack of meat in diet which is one of its main sources. Just after Goldberger’s death, his hypothesis was proven, which is why he was nominated for a Nobel Prize five times.

The consequences of niacin deficiencies
According to this, niacin deficiency can lead to a disease called pellagra or 3D disease, because of its main aspects – dermatitis (symmetrical rash in places exposed to sunlight, tongue inflammation), diarrhoea and dementia (neurological disorders – depression, memory losses, fatigue, apathy and headaches).

Risk factors of niacin deficiency
Risk factors of niacin deficiency include not only improper diet poor in niacin sources, but also chronic alcohol abuse and disorders of tryptophan metabolism (an amino acid which is transformed into niacin). Transformation of tryptophan into niacin is determined by a number of factors, i.a. hormonal activity, genes, individual differences; deficiency of vitamins B2 and B6 and iron as well as leucine excess slows down the transformations.

Reduction in migraine attacks and tension headaches
Niacin is used for the treatment of migraines and tension headaches. It has been observed that the vitamin contributes to dilatation of subcutaneous vessels, which reduces migraine symptoms, dilatates intracranial vessels and counteracts narrowing of the extracranial vessels. There are some evidences that niacin applied every day for preventive purposes supports the proper energy metabolism in mitochondria, so that it reduces the frequency of muscle tension and pain.

Support for antioxidant processes
Niacin shows antioxidant properties. An increase in NADH level in cells leads to increased activity of glutathione reductase, which plays a crucial role in supporting cells detoxification of H₂O₂. Moreover, niacin can inhibit lipids peroxidation and glutathione oxidation.

Maintenance of the proper lipid level in blood
Niacin supports stabilisation of lipid levels in blood. It has been demonstrated that nicotinic acid normalises concentration of all lipids and lipoproteins fractions in blood. The vitamin significantly reduces the levels of LDL cholesterol and triglycerides and at the same time raises HDL cholesterol level, so that it reduces the risk of development of atherosclerotic clot and coronary artery disease and supports treatment of dyslipidaemia, particularly in people with type 2 diabetes.

To sum it all up, Niacin Time-Released With Niaxtend is a dietary supplement which effectively complements vitamin B3 deficiency. The product is especially recommended for improving regulation of lipid parameters and for prevention of cardiovascular diseases, dyslipidaemia and type 2 diabetes. Moreover, it can be also effective in case of migraines and tension headaches.