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Seeking Health Vitamin D3+K2 is a dietary supplement ensuring the complex of vitamins demonstrating synergistic effect in ensuring proper bone mineralization – vitamin D3 at the dose of 5000 IU (in the form of cholecalciferol) and vitamin K2 MK-7 (as menachinone-7). Cholecalciferol has been obtained from ship wool, which makes the product appropriate for vegetarians.
Vitamin D3 (cholecalciferol) is a vitamin of steroid structure. It is produced from provitamins D3 (7-dehydrocholesterol) present in epidermis and dermis under the influence of UV-B radiation. It is transformed in the liver and kidneys to biologically active forms – calcidiol (25(OH)D3) and calcitriol (1,25(OH)D3).
Calcitriol has influence on target cells (i.a. epithelial cells of intestines, bones, heart, brain, beta cells of the pancreas) by means of nuclear receptors VDR, controlling the expression of more than 200 genes. Moreover, calcitriol demonstrates affinity to membrane receptors, activating in this way kinases, proteases and inducing the synthesis of prostaglandins.
Vitamin D3 is responsible for proper calcium-phosphorus balance, conditioning optimal mineralization of bones and at the same time preventing the development of osteoporosis. It regulates the immune response by the stimulation of decreasing inflammatory reactions. It is also essential for the proper functioning of the circulatory system. It increases the level of glutathione, a powerful antioxidant in the organism, protecting from the toxic activity of free radicals and facilitating liver detoxification.
Vitamin K belongs to the group of vitamins soluble in fats, quinone derivatives. In the group of vitamins K we may distinguish vitamin K1 (phylloquinone), K2 (menaquinone) and synthetic K3 (menadione). These forms are different in bioavailability, activity and partially in the influence on the organism. In general, vitamin K is the substance that conditions optimal blood coagulation, influencing the synthesis of prothrombin (thrombin precursor, factor II of coagulation) and factors VII, IX, X. It is also essential for the synthesis and modification of proteins taking part in building bones and also it demonstrates antibacterial effect.
Vitamin K2 (menaquinone), contrary to phylloquinone, it is redistributed by the liver and blood in the whole organism, thanks to which it is highly available for tissues, such as bones or blood vessel walls. Clinical research confirmed the effectiveness of vitamin K2 in reducing the frequency of bone fractures. A superior role of menaquinone is modification and activation of proteins taking part in building them – osteocalcin, transporting proteins, enabling storing calcium in bones instead of artery walls. Deficiency of vitamin K2, by its participation in regulation of calcium transport is a common denominator of osteoporosis and circulatory system diseases.
Osteocalcin is a biological marker of bone formation. It is synthesized by osteoblasts and osteocytes. Vitamin K2 influences the expression of osteoblastic markers of bones by the activation of SXR receptors (Steroid and Xenobiotic Receptor). Osteocalcin has the ability to bind calcium ions and maintain them in bones. In case of the lack of active osteocalcin (low level of vitamin K2), calcium is stored in the arteries, leading to blood vessel calcification and consequently the development of atherosclerosis and the increase of the risk of heart attack. Proper distribution of calcium is therefore incredibly important in preventing cardiovascular system diseases – ailments which are the main civilization diseases.
To sum up, Seeking Health Vitamin D3+K2 is a dietary supplement containing a set of vitamins with a wide spectrum of pro-health properties. Optimal dose and highly assimilable forms of vitamin D3 and K2 ensure effectiveness of the preparation. The supplement is especially recommended in order to ensure proper mineralization of bones and teeth, support the immune system, prevent cardiovascular system diseases and to improve general well-being and the state of health.
Studies unambiguously indicate that simultaneous supplementation with vitamin K2 and D3 results in higher mineral density of bones than supplementation with only vitamin D3.
Vitamin D3 and K2 belong to vitamins soluble in fats. Therefore, in order to ensure optimal assimilability of the preparation, the recommended dose should be taken with a meal containing fat.
In case of the simultaneous supplementation with vitamin D3 and K2, one should remember about proper ratio of these vitamins to ensure proper bone mineralization – at least 100 mcg of vitamin K2 per each 5000 IU of vitamin D3. The producer took care of this ratio in the preparation.
Seeking Health is a brand which makes sure that the products it produces are characterized by high quality and purity, therefore the majority of their products is free from magnesium stearate, allergens and GMO.
This brand is directed at fighting the causes and not the symptoms, therefore the aim of the company is primarily to help in ensuring optimal work of the digestive system, among others by launching on the market high-class products supporting digestion and regenerating and nourishing the intestines, which consequently improves bioavailability of the substances beneficial to health and increases organism’s resistance to the effect of toxins coming from external environment.
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HPMC (capsule), microcrystalline cellulose, ascorbyl palmitate, and silica.
Vitamin D belongs to fat soluble vitamins, occurs in three forms: calciferol (vitamin D1) ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3), it is formed under the action of sunlight for at least 15 minutes per day. In the absence of sunlight it should be administered in the diet in the form of fish oil (Vitamin A + D3) and fish oils. It is responsible for the absorption of calcium and phosphorus. It is the building substance of bone tissue particularly necessary during pregnancy, childhood, and for athletes. It is a component of dietary supplements and nutrients among competetive athletes. Deficiency of vitamin D causes children growth inhibition, and rickets.
For adults - deficiency causes osteomalacia.
Excess of vitamin D causes headaches, alopecia, nausea, drowsiness, blurred vision, pain in the long bones, the deposition of calcium deposits.
Dosage: 400 IU units during the day.
Cholecalciferol, or vitamin D3, is an organic chemical that belongs to the family of D vitamins. It is naturally found in fatty fish, fish oil, egg yolks, milk and dairy products. It is also synthesized in the human body. It is formed from 7-dehydrocholesterol present in the keratinocytes of the spinous and the basal layers of the epidermis, and a pre-requisite for initiating this process is the action of 290-315 nm wavelength UVB radiation on the skin.
Cholecalciferol is a biologically inactive compound. In the body, it undergoes enzymatic hydroxylation – first in the liver, with the participation of 25-hydroxylase, when calcidiol is formed and secondly in the kidneys, where under the influence of 1-α-hydroxylase, calcidiol is converted into the final active form – calcitriol.
The most important role of vitamin D3 in the body is the regulation of calcium-phosphate metabolism, which directly affects normal skeletal mineralization. In addition, it is involved in cell proliferation and differentiation, insulin secretion, as well as in some functions of the nervous, endocrine and immune systems.
Cholecalciferol is the most popular form of vitamin D used in dietary supplements. Studies show that supplementation with vitamin D in this form most effectively and rapidly raises the level of 25 (OH) D3 – a metabolite that is a marker of the level of vitamin D in the body.
Dosage: according to RDI standards for individual age groups.
What is Vitamin K2?
Vitamin K2 belongs to fat-soluble vitamins It is an important activator of many enzymes and proteins It shows a positive action on calcium balance by activating MGP protein and osteocalcin. This results in the removal of calcium deposits from blood vessel walls and transport of ions of this element to the area where it fulfills its function – teeth and bones. It reduces therefore the calcification of blood vessels and thus the risk of cardiovascular diseases. Moreover, it is a constituent of coagulation factors and cosequently prevents haemorrhages. It shows a synergistic action in combination with vitamin D and magnesium.
Vitamin K2 in the form of a dietary supplement of renowned brands e.g. Now Foods, Swanson, Life Extension, Jarrow Formulas and Thorne Research) can be found in formulas available at www.muscle-zone.pl
What is menaquinone-7?
Menaquinone-7 is a term used for long-chain form of vitamin K2, having seven isoprene residues in the side chain. Contrary to another popular form MK-4, it is not synthesized in tissues, however, it may be produced in the intestines by means of the conversion from vitamin K1 by intestinal bacteria.
It exhibits especially positive influence on the health of the circulatory system, especially by lowering the risk of atherosclerosis and heart attacks. It owes this effect mainly to osteocalcin, activated by vitamin K2. This hormone is responsible among others for the transport of calcium to bones, which counteracts its storage in soft tissues, decreasing at the same time the probability of blood vessel calcification and the creation of atherosclerotic plaques. K2 MK-7 also contributes to protecting the nervous system, securing neurons from excitotoxicity induced by excessive activity of glutamate and reducing the consequences of excessively low level of glutathione.
Vitamin K2 in the form of menaquinone-7 is a very popular additive to supplements with vitamin D3, due to the synergy of effects and reducing potential negative effects of applying higher doses of cholecalciferol.
Menaquinone-7 may be found both in monopreparations and complex supplements in the offer of muscle-zone.pl.
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