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Active B12 with L-5-MTHF Active B12 with L-5-MTHF 60 lozenges
Seeking Health
21.19 $

Active B12 with L-5-MTHF 60 lozenges

Servings: 60 lozenges
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For free shipping is missing: 75.00 $
21.19 $With VAT
0.35 $ / serving

From 3 units only 20.77 $ /Units. -2%

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  • Supplement with active forms of vitamin B9 and B12
  • Formula in the form of convenient lozenges
  • Promotes normal activation of many enzymes
  • Improves mitochondrial energy production
  • Protects cells from harmful factors
  • Regulates levels of many neurotransmitters
  • Promotes red blood cell production
  • Boosts methionine and melatonin levels
  • Reduces elevated homocysteine levels
  • Improves nervous system function
  • Allergen-free supplement
  • Improves cognitive functions

Active B12 with L-5-MTHF by Seeking Health is a dietary supplement in the form of lozenges which contains active forms of vitamin B9 (levomefolic acid) and B12 (methylcobalamin and adenosylcobalamin). Active substances in these forms ensure efficient absorption and high bioactivity of both vitamins. Both ingredients have a positive effect on normal function of the whole body and protect its tissues from a harmful impact of external factors.

Active forms of vitamin B12 – this vitamin, otherwise known as cobalamin, is found in the supplement in the form of two bioactive ingredients: methylcobalamin and adenosylcobalamin. They do not need to be activated after absorption and that is why the administered dose shows its full biological effect.

Methylcobalamin is a form of vitamin B12 which contains a methyl group. Its presence influences positively the process called methylation. The main goal of methylation is to activate and deactivate many enzymes which regulates the function of the whole body. Harmful factors which we encounter on a daily basis decreases the efficiency of this process. This contributes to declining health and the lack of energy. In addition, it happens more often that the MTHFR gene, which is directly responsible for methylation in the body, is mutated. Because of that, adequate vitamin B12 supplementation is very important.

The second form of vitamin B12 in this supplement is adenosylcobalamin. It is also an active form which has a positive effect on many processes directly after absorption. It is a cofactor necessary for normal function of methylmalonyl-CoA that is responsible for mitochondrial energy production.

Cobalamin has also a beneficial effect on the immune system. It activates the enzyme methionine synthase which converts homocysteine into methionine. It is a very significant process because high homocysteine levels have a negative impact on the function and structure of blood vessels. They cause many diseases which include thrombosis and atherosclerosis. Owing to that, vitamin B12 prevents blood vessel degeneration which contributes to normal cardiovascular function.

In addition, it stimulates the production of red blood cells. This helps combat effectively anaemia and improves gas exchange in the body. Adequate oxygen supply to cells contributes to efficient mitochondrial energy production.

Vitamin B12 has also been shown to influence positively the nervous system. It protects nerve cells, neurons, from overactivation of glutamate receptors. Binding large amounts of glutamate to them causes excitation that damages severely neurons. What is more, a reduction in homocysteine levels helps maintain a good condition of blood vessels which provide the brain with oxygen. The removal of metabolic waste products is also improved which contributes to efficient function of the central nervous system. The overall nourishing and neuroprotective effect of vitamin B12 on the nervous system promotes memory formation, improves cognitive functions and fosters general well-being.

The methionine synthase activated by cobalamin converts homocysteine into methionine, which has a positive impact on metabolism of cells. It protects them from mutation and promotes normal synthesis of proteins, lipids and DNA.

Levomefolic acid (5-MTHF) – is a bioactive form of vitamin B9. Many studies show that it acts in synergy with other vitamins from this group, in particular with vitamin B12. An important feature of levomefolic acid is that it crosses easily the blood-brain barrier. Owing to that, it demonstrates a significant impact on the functioning of the nervous system which controls the function of the whole body.

Vitamin B9 regulates levels of such neurotransmitters as dopamine, noradrenaline and serotonin. This has a significant impact on thought processes and ensures well-being. The brain’s chemical balance inhibits also neurodegenerative processes.

Proper vitamin B9 levels helps protect the neurolemma from harmful factors. Its function is to ensure normal transmission of nerve impulse within a neuron. This contributes to inhibiting neurodegenerative processes and slows down the development of many diseases connected with these processes.

In addition, levels of melatonin, the hormone responsible for normal sleep and body regeneration, are normalised.

Like cobalamin, vitamin B9 contributes to reducing homocysteine levels which results in improved function of blood vessels. What is more, it stimulates the proliferation and differentiation of red blood cells in erythropoiesis which helps combat effectively anaemia.

Active B12 with L-5-MTHF is a dietary supplement which contains high doses of active forms of vitamin B12 and B9. Maintaining normal levels of these vitamins is a crucial factor which regulates properly the function of the whole body. The formula is designed for individuals who are exposed to strong mental stress and all individuals who struggle with an impaired methylation process. An additional target group are individuals with high homocysteine levels. This results from the fact that active substances in the supplement stimulate effectively the body into normalising levels of this amino acid. The formula in the form of lozenges is a convenient way to divide easily doses of the supplement.

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Container size: 60 lozengesServing size: 1 lozengeServings per container: 60
per portion (1 lozenge)amount%DV
Folate (as Quatrefolic® (6S)-5-methyltetrahydrofolate, glucosamine salt)800 mcg340%
Vitamin B12 (as methylcobalamin and adenosylcobalamin)1000 mcg41667%

Other ingrednients

Xylitol, ascorbyl palmitate, natural cherry flavor, and silica.

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Quatrefolic is the glucosamine salt of (6S)-5-methyltetrahydrofolate and also an active form of folic acid. It is an innovative nutrient (fourth generation folate) which is well soluble in water and thus absorbed effectively by the body. As an organic compound ranked among B vitamins, it is necessary for normal functioning at the cellular level.

Adding folates to a diet is recommended especially to pregnant and lactating women. These compounds may contribute to healthy foetal development. According to studies, their intake may reduce the incidence of pregnancy complications.

Some sources report that folate supplementation supports cardiovascular function (blood production) and contribute to healthy immune function.

Quatrefolic may affect the metabolism of homocysteine whose levels increase in the body over time. Adding it to a diet may thus prevent the development of dementia and maintain healthy cognitive functions which is vital to adults, especially the elderly.



Salt (sodium chloride, or table salt), natural source of electrolytes (chlorine and potassium), regulating water and electrolyte and acid-base balance of the body, affecting the nervous system and blood pressure. Sodium is an essential element for the proper growth. The proper dose of salt prevents overheating of the body and solar stroke. It provides the proper functioning of muscles and nerves the body. Chlorine in combination with sodium, is involved in the digestive process and maintains acid-base balance in the body, as antitoxin removes toxic products of metabolism in the liver. Salt is a flavour component and preservative of many foods, nutritional supplements and mixtures of electrolytes, available at

Dosage: no specific standards of consumption, used so as to provide sufficient amount of electrolytes to the body (sodium and chloride).




What is methylcobalamin?

Methylcobalamin is a biologically active form of vitamin B12. It is one of the two forms of this vitamin that may be used as cofactors in various reactions. It differs from popular cyanocobalamin in the presence of methyl group instead of cyanide, thanks to which it releases the organism from the need of neutralizing this harmful factor.

The methyl group from methylcobalamin may be transferred to homocysteine, thanks to which it comes back in the form of methionine in order to be further converted to SAMe, which is the main donor of methyl groups in our organism. These methyl groups may be then used in the processes of creatine production, in neurotransmitter metabolism and as DNA methylation, thanks to which we achieve proper energy level, better well-being and generally better condition of the organism. B12 is a coenzyme for three enzymes: isomerase, methyltransferase and dehalogenase.

Apart from the influence on the nervous system, the supply of vitamin B12 is also very important for the proper synthesis of red cells as well as hemoglobin and anemia prevention.


Methylcobalamin in mono-supplements and complex vitamin preparations may be found in the offer of



Adenosylcobalamin - a biologically active form of vitamin B12, which similarly to its methylated form does not need to undergo additional biochemical transformations in order to enter metabolic pathways in the human organism.

Apart from the best assimilability, adenosylcobalamin is distinguished from other forms of vitamin B12 by its high affinity for regeneration of nervous tissue. It is indicated that this form of cobalamin is engaged in the production of myelin sheaths with key meaning for proper neurotransmission. Apart from this, vitamin B12 is conducive to maintaining optimal functionality of the nervous system, being conducive to the synthesis of neurotransmitters.

Vitamin B12 is also an incredibly important regulator of methylation process, thanks to which its supplementation positively influences metabolism of the whole organism. It is a coenzyme in the conversion reactions of homocysteine to methionine as well as methylmalonyl-CoA to succinyl-CoA. Because of the first reaction, proper supply of vitamin B12 is also conducive to maintaining high concentrations of S-adenosylmethionine, thanks to which it positively influences mental functions.

Moreover, vitamin B12 is a key regulatory factor, taking part in erythropoiesis, i.e. the process of forming red cells. Its improper supply may be the cause of the development of the so-called vitamin B12 deficiency anemia.

Supplementation with vitamin B12 should be considered especially be people on vegetable diets and those who take drugs from the group of proton-pump inhibitors (PPIs) and metformin.


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